PDF
Full
Outline
AIM To observe the efficacy and safety of bendamustine combined with chemotherapy for relapsed and refractory multiple myeloma（RRMM）. METHODS A retrospective analysis was conducted on 32 RRMM patients treated with bendamustine combined with chemotherapy in the Department of Hematology and Oncology, Shijingshan Campus of Beijing Chaoyang Hospital, Capital Medical University from August 2019 to September 2022. The efficacy, adverse reactions and survival conditions were observed. RESULTS Thirty-two patients completed 3（1, 8） treatment courses. The overall response rate（ORR） was 38%（11/29） for 29 patients who completed ≥2 treatment courses, and the ORR was 73%（11/15）for 15 patients who completed≥4 treatment courses. The ORR was 26%（5/19） for 19 patients with extramedullary diseases,and the disease control rate was 53% （10/19）. The estimated median progression-free survival was 11 months, and the estimated median overall survival was 25 months for the 32 RRMM patients. Sixteen patients experienced adverse reactions of decreased white blood cell count with the grade from 1 to 3. CONCLUSION Bendamustine combined with chemotherapy has the advantages of good therapeutic response and good tolerance in the treatment of RRMM, and can be used as one of the treatment options for RRMM patients, especially for those with extramedullary diseases.
PDF
146
69
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
