Home Journals Articles Updates About
CN
image
收藏切换
Research progress of migraine drugs targeting pathway of calcitonin gene-related peptide
收藏切换
PDF
Rui-juan LIU1, 2, Yue-feng RAO2, Jian-guo ZHU1
Chinese Journal of New Drugs and Clinical Remedies | 2025, 44(4) : 257 - 264
Less
收藏切换
Chinese Journal of New Drugs and Clinical Remedies | 2025, 44(4): 257-264
• Review •
Research progress of migraine drugs targeting pathway of calcitonin gene-related peptide
Full
Rui-juan LIU1, 2, Yue-feng RAO2, Jian-guo ZHU1
Affiliations
  • 1. Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou JIANGSU 215000, China
  • 2. Department of Clinical Pharmacy, the First Affiliated Hospital of Zhejiang University Medical College, Hangzhou ZHEJIANG 310003, China
Published: 2025-04-25 doi: 10.14109/j.cnki.xyylc.2025.04.04
Outline
收藏切换

Migraine is a recurrent neurological disorder recognized by the World Health Organization as the second leading cause of disability. Currently, most available pharmacological interventions for migraine prevention and treatment are either non-specific or associated with contraindications and serious adverse reactions. Recent research has focused on calcitonin gene-related peptide （CGRP）, which plays a pivotal role in the pathophysiological mechanisms underlying migraine. Targeted CGRP pathway inhibitors have been developed, including CGRP receptor antagonists （gepants） and anti-CGRP monoclonal antibodies. Current studies indicate that these agents demonstrate favorable safety profiles, efficacy,and tolerability. This paper reviewed relevant clinical trials and research findings of targeting the CGRP pathway, aiming to provide a foundation for future selection of domestic migraine therapeutics.

migraine  /  calcitonin gene-related peptide  /  gepants  /  monoclonal antibodies
Rui-juan LIU, Yue-feng RAO, Jian-guo ZHU. Research progress of migraine drugs targeting pathway of calcitonin gene-related peptide[J]. Chinese Journal of New Drugs and Clinical Remedies, 2025 , 44 (4) : 257 -264 . DOI: 10.14109/j.cnki.xyylc.2025.04.04
Appendix
Less
Year 2025 volume 44 Issue 4
PDF
223
106
Cite this Article
BibTeX
Article Info
doi: 10.14109/j.cnki.xyylc.2025.04.04
  • Receive Date：2024-05-29
  • Online Date：2025-12-15
  • Published：2025-04-25
Article Data
Affiliations
History
  • Received：2024-05-29
  • Accepted：2025-02-10
Affiliations
    1. Department of Pharmacy, the First Affiliated Hospital of Soochow University, Suzhou JIANGSU 215000, China
    2. Department of Clinical Pharmacy, the First Affiliated Hospital of Zhejiang University Medical College, Hangzhou ZHEJIANG 310003, China
References
Share
https://castjournals.cast.org.cn/joweb/zgxyylczz/EN/10.14109/j.cnki.xyylc.2025.04.04
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House