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Investigation and countermeasure of potential adverse drug interactions of non-vitamin K antagonist oral anticoagulants
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Long WANG1, Li ZHANG2, Ling-na ZHU1, Jun CHENG1
Chinese Journal of New Drugs and Clinical Remedies | 2025, 44(4) : 299 - 306
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Chinese Journal of New Drugs and Clinical Remedies | 2025, 44(4): 299-306
• Original Article •
Investigation and countermeasure of potential adverse drug interactions of non-vitamin K antagonist oral anticoagulants
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Long WANG1, Li ZHANG2, Ling-na ZHU1, Jun CHENG1
Affiliations
  • 1. Department of Pharmacy, the Third People's Hospital of Bengbu, Bengbu ANHUI 233099, China
  • 2. Department of Pharmacy, the Second Affiliated Hospital of Bengbu Medical University, Bengbu ANHUI 233004, China
Published: 2025-04-25 doi: 10.14109/j.cnki.xyylc.2025.04.10
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AIM To analyze the potential adverse drug interactions （pADIs） of non-vitamin K antagonist oral anticoagulants （NOAC）, and to promote rational drug use. METHODS Outpatient prescriptions of using NOAC in combination with other drugs were surveyed from January 1, 2024 to May 31, 2024 through the information system of the third people's hospital of Bengbu, and pADIs were identified and their severities were graded. Refined prescription pre-review rules were developed by rational drug software. RESULTS Among 1 153 NOAC combined prescriptions, 406 prescriptions had 511 cases of pADIs, including 180 cases of dabigatran etexilate, 288 cases of rivaroxaban and 43 cases of apixaban.The combined drugs involved antiepileptic, antiplatelet, Chinese medicines containing salvia/ginseng/ginkgo biloba and antiarrhythmic drugs. Rivaroxaban + phenobarbital severity classification was contraindicated. Refined rules included 1 interception rule and 10 alert information + double-signature rules and 8 attention information rules. CONCLUSION There are pADIs between NOAC and other drugs in the hospital. The medication risks can be prevented through targeted intervention based on evidence-based refined prescription pre-review rules.

anticoagulants  /  drug interactions  /  evidence-based medicine  /  cytochrome P-450 CYP3A4  /  p-glycoprotein
Long WANG, Li ZHANG, Ling-na ZHU, Jun CHENG. Investigation and countermeasure of potential adverse drug interactions of non-vitamin K antagonist oral anticoagulants[J]. Chinese Journal of New Drugs and Clinical Remedies, 2025 , 44 (4) : 299 -306 . DOI: 10.14109/j.cnki.xyylc.2025.04.10
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Year 2025 volume 44 Issue 4
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Article Info
doi: 10.14109/j.cnki.xyylc.2025.04.10
  • Receive Date：2024-06-17
  • Online Date：2025-12-15
  • Published：2025-04-25
Article Data
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History
  • Received：2024-06-17
  • Accepted：2025-01-05
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Affiliations
    1. Department of Pharmacy, the Third People's Hospital of Bengbu, Bengbu ANHUI 233099, China
    2. Department of Pharmacy, the Second Affiliated Hospital of Bengbu Medical University, Bengbu ANHUI 233004, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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