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AIM To evaluate the cost-effectiveness of insulin degludec-liraglutide（iDegLira） versus insulin glargine-lixisenatide （iGlarLixi） in Chinese adult type 2 diabetes mellitus （T2DM） patients. METHODS From the perspective of China’s health system, a Markov model was developed. Quality-adjusted life years （QALY） were used as the health output indicator, and three times 2023 gross domestic product （GDP） per capita of China was used as the willingness-to-pay （WTP） threshold. The model simulates the health output and medical costs over 30 years, evaluates the economics of the two treatment options using the incremental cost-effectiveness ratio （ICER） as an evaluation metric, and performs sensitivity and contextual analyses to test the uncertainty of the results. RESULTS Compared with the iGlarLixi scheme,iDegLira scheme had an incremental cost of 46 142.61 yuan, an incremental utility of 0.014 QALY. The ICER was 3 258 162.70 yuan·QALY-1, which was much larger than the WTP threshold （268 074 yuan·QALY-1） and was not cost-effectiveness. The results of the sensitivity analysis show that the underlying analysis was relatively robust. The results of the contextual analysis showed that the cost-effectiveness of the two schemes was comparable when the price was reduced by 31% at the current WTP threshold. CONCLUSION For Chinese adult T2DM patients with poor glycemic control despite receiving basal insulin in combination with oral hypoglycemic agents, iDegLira scheme has a lower probability of being economical at current prices compared with the iGlarLixi scheme.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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