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AIM To evaluate the effectiveness, safety and economy of mepolizumab so as to provide evidence-based references for selection and clinical rational usage of drugs. METHODS Chinese and English literature and clinical trials were systematically retrieved, including health technology assessment （HTA） reports, systematic reviews/meta-analysis and pharmacoeconomic studies on mepolizumab versus placebo or other drugs for eosinophilic asthma. The literature was screened according to inclusion and exclusion criteria, the quality of the literature and extract data were evaluated,and a summary analysis was conducted. RESULTS A total of 1 HTA report, 11 systematic reviews/meta-analyses and 4 pharmacoeconomic studies were included. The results showed that mepolizumab had the same efficacy and safety as other IL-5/IL-4 and IgE antagonism, with no difference in safety compared to placebo. Meanwhile, it could significantly reduce asthma exacerbation and eosinophil counts in sputum or blood, significantly reduce the use of oral glucocorticoids and rescue drugs, improve lung function to a certain extent, and subsequently control asthma symptoms, and improve patients’ quality of life. However, it did not meet the minimum of clinical significant improvement. In terms of economy, due to the current price,the conclusions on economics were not consistent. CONCLUSION Mepolizumab in the treatment of eosinophilic asthma has the same efficacy, safety and economy as other monoclonal antibodies, but due to the current price, it does not have a clear economic advantage over standard treatment. As a result, further economic research on the Chinese population needs to be carried out.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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