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Association of vaccine knowledge and vaccine literacy with vaccine hesitancy among parents of preschool children
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Shuwen DONG1, Yuqian WU1, Liwan ZHU2, Yuexian ZENG3, Xinrong XIANG1, Jianzhe GAN1, Li REN*, 4
Chinese Journal of School Health | 2025, 46(11) : 1580 - 1583
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Chinese Journal of School Health | 2025, 46(11): 1580-1583
• Health Education and Promotion •
Association of vaccine knowledge and vaccine literacy with vaccine hesitancy among parents of preschool children
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Shuwen DONG1, Yuqian WU1, Liwan ZHU2, Yuexian ZENG3, Xinrong XIANG1, Jianzhe GAN1, Li REN*, 4
Affiliations
  • 1Department of Public Health Data Management, Guangzhou Center for Disease Control and Prevention/Guangzhou Health Supervision Institute, Guangzhou 510440, Guangdong Province, China
Published: 2025-11-25 doi: 10.16835/j.cnki.1000-9817.2025346
Outline
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Objective

To investigate the mediating role of vaccine literacy between vaccine knowledge and vaccine hesitancy and the moderating role of parental education level, so as to provide references for adjusting vaccination strategies.

Methods

From May to December 2024, a stratified random sampling method was used to select 10 community hospitals in Guiyang and Zunyi City, Guizhou Province. A total of 1 401 parents of children aged 0-6 years were surveyed regarding their socio-demographic characteristics, vaccine knowledge, vaccine literacy, and vaccine hesitancy levels. Data were analyzed using common method bias tests, Spearman correlation analysis, mediation and moderation effects tests.

Results

The mean score for vaccine knowledge, vaccine literacy and vaccine hesitancy were (2.96±1.11, 14.25±2.64, 39.12±4.93) among the 1 401 participants. Mediating effect analysis showed that both parental vaccine knowledge (β=1.28, 95%CI=1.08-1.49) and vaccine literacy (β=0.75, 95%CI=0.66-0.84) positively predicted vaccine hesitancy (both P < 0.01). Meanwhile, vaccine literacy accounted for 28.1% of the total effect of mediation between knowledge and vaccine hesitancy. In the moderated effects analysis, education level positively predicted vaccine literacy (β=0.40, 95%CI=0.24-0.57), and education level moderated the pathway of vaccine knowledge on vaccine hesitancy (β=0.28, 95%CI=0.05-0.52) (both P < 0.01).

Conclusions

Vaccine literacy partially mediates the relationship between vaccine knowledge and vaccine hesitancy. Parental education level positively moderates the prediction of vaccine knowledge on vaccine hesitancy score.

Vaccines  /  Knowledge  /  Health education  /  Attitude  /  Child, preschool
董淑文, 吴宇骞, 朱立婉, 曾月贤, 向欣荣, 甘建哲, 任丽. 学龄前儿童父母疫苗知识和疫苗素养与疫苗犹豫的关联. 中国学校卫生, 2025 , 46 (11) : 1580 -1583 . DOI: 10.16835/j.cnki.1000-9817.2025346
Shuwen DONG, Yuqian WU, Liwan ZHU, Yuexian ZENG, Xinrong XIANG, Jianzhe GAN, Li REN. Association of vaccine knowledge and vaccine literacy with vaccine hesitancy among parents of preschool children[J]. Chinese Journal of School Health, 2025 , 46 (11) : 1580 -1583 . DOI: 10.16835/j.cnki.1000-9817.2025346
Year 2025 volume 46 Issue 11
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1
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doi: 10.16835/j.cnki.1000-9817.2025346
  • Receive Date:2025-04-17
  • Online Date:2026-11-06
  • Published:2025-11-25
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  • Received:2025-04-17
  • Revised:2025-08-18
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    1Department of Public Health Data Management, Guangzhou Center for Disease Control and Prevention/Guangzhou Health Supervision Institute, Guangzhou 510440, Guangdong Province, China
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
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