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Research progress on the effects of exercise on gut microbiota among children with autism spectrum disorder
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Xiang PAN1, 2, 3, Yibo GAO1, 2, Lupei JIANG1, 2, Xiaoxiao CHEN1, 4, Yibei WANG1, Deqiang ZHAO1, Yanfeng ZHANG*, 1
Chinese Journal of School Health | 2025, 46(12) : 1815 - 1819
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Chinese Journal of School Health | 2025, 46(12): 1815-1819
• Review •
Research progress on the effects of exercise on gut microbiota among children with autism spectrum disorder
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Xiang PAN1, 2, 3, Yibo GAO1, 2, Lupei JIANG1, 2, Xiaoxiao CHEN1, 4, Yibei WANG1, Deqiang ZHAO1, Yanfeng ZHANG*, 1
Affiliations
  • 1China Institute of Sport Science, Beijing 100061, China
Published: 2025-12-25 doi: 10.16835/j.cnki.1000-9817.2025359
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To investigate the effects of exercise on gut microbiota(GM) among children with autism spectrum disorder(ASD), the review provides an in-depth summary of the three core biological pathways through which exercise modulates the GM: repairing the integrity of the intestinal barrier to inhibit lipopolysaccharide-mediated neuroinflammation; optimizing key metabolites, such as short-chain fatty acids, to reshape gut-brain communication; synergistically regulating the tryptophan-kynurenine metabolic pathway and vagus nerve signaling to balance neurotransmitters. These interconnected pathways not only alleviate gastrointestinal discomfort but also provide a solid biological foundation for improving the core behavioral symptoms of ASD, such as social deficits and repetitive behaviors. Future research should focus on establishing standardized exercise intervention protocols, validating the efficacy of these key biological pathways using multi-omics approaches, and exploring combined intervention strategies. The results of corollary studies will provide a more robust scientific basis for precision rehabilitation of children with ASD.

Motor activity  /  Autistic disorder  /  Gast rointestinal tract  /  Bacteria  /  Child
潘祥, 高艺博, 江露沛, 陈潇潇, 王艺蓓, 赵德强, 张彦峰. 运动对孤独症谱系障碍儿童肠道菌群影响的研究进展. 中国学校卫生, 2025 , 46 (12) : 1815 -1819 . DOI: 10.16835/j.cnki.1000-9817.2025359
Xiang PAN, Yibo GAO, Lupei JIANG, Xiaoxiao CHEN, Yibei WANG, Deqiang ZHAO, Yanfeng ZHANG. Research progress on the effects of exercise on gut microbiota among children with autism spectrum disorder[J]. Chinese Journal of School Health, 2025 , 46 (12) : 1815 -1819 . DOI: 10.16835/j.cnki.1000-9817.2025359
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Year 2025 volume 46 Issue 12
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Article Info
doi: 10.16835/j.cnki.1000-9817.2025359
  • Receive Date：2025-07-11
  • Online Date：2026-11-06
  • Published：2025-12-25
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  • Received：2025-07-11
  • Revised：2025-10-19
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    1China Institute of Sport Science, Beijing 100061, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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