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Meta-analysis of maternal overweight/obesity during pregnancy and offspring metabolic dysfunction-associated steatotic liver disease
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Yuying WU1, 2, Nuer ENKAER1, 2, Youxin WANG1, 2, Mingyue WANG1, 2, Yifan YANG1, 2, Shuhan YANG1, 2, Lingling SUN*, 2, 3, Hui WANG*, 1, 2
Chinese Journal of School Health | 2025, 46(8) : 1079 - 1083
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Chinese Journal of School Health | 2025, 46(8): 1079-1083
• Impact of Maternal Adverse Factors during Pregnancy on Childhood Growth and Development •
Meta-analysis of maternal overweight/obesity during pregnancy and offspring metabolic dysfunction-associated steatotic liver disease
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Yuying WU1, 2, Nuer ENKAER1, 2, Youxin WANG1, 2, Mingyue WANG1, 2, Yifan YANG1, 2, Shuhan YANG1, 2, Lingling SUN*, 2, 3, Hui WANG*, 1, 2
Affiliations
  • 1Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China
Published: 2025-08-25 doi: 10.16835/j.cnki.1000-9817.2025259
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Objective

To evaluates the association between maternal overweight/obesity during pregnancy and offspring risk of metabolic dysfunction-associated steatotic liver disease (MASLD), providing theoretical evidence for early-life MASLD prevention.

Methods

An online search was conducted across ten databases (CNKI, Wanfang, SinoMed, PubMed, Embase, Web of Science, Cochrane Library, PROSPERO, PQDT Global, ScienceDirect) for research literature on the association between maternal overweight/obesity during pregnancy and the development of MASLD in offspring, with the search period spanning from January 2014 to December 2024. Two researchers independently screened literature, extracted data, and assessed study quality. Statistical analysis was performed using R 4.3.3.

Results

Ten studies involving 10 229 participants were included, comprising 4 cohort studies and 6 case-control studies. Cohort studies showed that maternal overweight and obesity significantly increased offspring MASLD risk (RR=1.59, 95%CI=1.06-2.39, P < 0.05), with moderate heterogeneity (I2=56.9%, P=0.07). Case-control studies indicated a positive association between maternal overweight/obesity during pregnancy and offspring risk of MASLD(OR=2.00, 95%CI=1.68-2.39, P < 0.05), with low heterogeneity (I2=48.8%, P=0.08).

Conclusions

Maternal overweight/obesity during pregnancy positively correlates with offspring MASLD risk. Gestational weight management may reduce the risk.

Pregnancy  /  Overweight  /  Obesity  /  Fatty liver  /  Meta-analysis
吴玉莹, 恩卡尔·努尔, 王佑新, 王明月, 杨依凡, 杨树涵, 孙玲玲, 王辉. 妊娠期超重肥胖和子代代谢相关脂肪性肝病的Meta分析. 中国学校卫生, 2025 , 46 (8) : 1079 -1083 . DOI: 10.16835/j.cnki.1000-9817.2025259
Yuying WU, Nuer ENKAER, Youxin WANG, Mingyue WANG, Yifan YANG, Shuhan YANG, Lingling SUN, Hui WANG. Meta-analysis of maternal overweight/obesity during pregnancy and offspring metabolic dysfunction-associated steatotic liver disease[J]. Chinese Journal of School Health, 2025 , 46 (8) : 1079 -1083 . DOI: 10.16835/j.cnki.1000-9817.2025259
Appendix
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Year 2025 volume 46 Issue 8
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Article Info
doi: 10.16835/j.cnki.1000-9817.2025259
  • Receive Date：2025-02-14
  • Online Date：2026-11-06
  • Published：2025-08-25
Article Data
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History
  • Received：2025-02-14
  • Revised：2025-04-30
Funding
Affiliations
    1Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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