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Research progress on regulation of the prostate cancer immune microenvironment by monoamine oxidase A and B
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Liting FANG1, 2, Yaohua HU2, Fang WANG3, Jumei ZHAO1, *, Changhong SHI2, *
Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3) : 432 - 441
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Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3): 432-441
Research progress on regulation of the prostate cancer immune microenvironment by monoamine oxidase A and B
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Liting FANG1, 2, Yaohua HU2, Fang WANG3, Jumei ZHAO1, *, Changhong SHI2, *
Affiliations
  • 1.Medical College of Yan'an University, Yan'an 716000, China
  • 2.Laboratory Animal Center, the Air Force Medical University, Xi'an 710032, China
  • 3.Department of Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
Published: 2026-03-30 doi: 10.3969/j.issn.1005-4847.2026.03.011
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Cancer-associated fibroblasts (CAFs) influence the progression and treatment of prostate cancer (PCa) by remodeling the tumor microenvironment (TME). Identifying the key molecular drivers of this remodeling is critical for advancing cancer research. The monoamine oxidase (MAO) family, comprising the subtypes MAOA and MAOB, is a group of mitochondrial outer membrane oxidases that regulate monoamine metabolism through oxidative deamination. Aberrant MAO expression is closely associated with PCa growth, invasion, metastasis, poor prognosis, and TME remodeling. This review, based on various animal models, systematically summarizes the biological roles of the distinct MAO subtypes in CAFs and their contributions to PCa pathogenesis. We further explore the potential of MAO inhibitors in combination therapies for PCa, focusing on their differential expression profiles and functional specificity. In addition, we propose precision diagnostic and therapeutic strategies targeting MAO subtypes, with the aim of identifying novel therapeutic targets for personalized PCa treatment.

prostate cancer  /  monoamine oxidase  /  cancer-associated fibroblasts  /  monoamine oxidase inhibitor
Liting FANG, Yaohua HU, Fang WANG, Jumei ZHAO, Changhong SHI. Research progress on regulation of the prostate cancer immune microenvironment by monoamine oxidase A and B[J]. Acta Laboratorium Animalis Scientia Sinica, 2026 , 34 (3) : 432 -441 . DOI: 10.3969/j.issn.1005-4847.2026.03.011
Funding
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  • National Natural Science Foundation of China(32270566)
Appendix
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Year 2026 volume 34 Issue 3
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Article Info
doi: 10.3969/j.issn.1005-4847.2026.03.011
  • Receive Date：2025-06-16
  • Online Date：2026-08-08
  • Published：2026-03-30
Article Data
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History
  • Received：2025-06-16
Funding
National Natural Science Foundation of China(32270566)
Affiliations
    1.Medical College of Yan'an University, Yan'an 716000, China
    2.Laboratory Animal Center, the Air Force Medical University, Xi'an 710032, China
    3.Department of Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Corresponding:

ZHAO Jumei. E-mail:
SHI Changhong. E-mail:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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