PDF
Full
Outline
Sepsis is a life-threatening condition associated with high mortality rates in clinical settings. The subsequent immunosuppressive state is strongly correlated with adverse patient outcomes. Establishing robust animal models is therefore essential for elucidating the pathophysiological mechanisms of sepsis-induced immunosuppression and developing therapeutic interventions. Current models, however, are predominantly employed in sepsis hyperinflammation studies, while their utilization specifically for the immunosuppression phase remains limited. In addition, standardized assessment criteria for immunosuppression are lacking across different investigations. Commonly employed models include cecal ligation and puncture (CLP) and lipopolysaccharide (LPS) administration. Although cecal ligation and puncture effectively recapitulates the clinical pathology, it suffers from significant outcome variability. Conversely, although lipopolysaccharide administration is technically straightforward, its artificial nature fails to replicate the polymicrobial pathogenesis of natural infection. Quantitative analysis of immune cell populations, cytokine profiles, and immune organ status provides a reliable assessment of immunosuppression severity in animal models. By synthesizing recent literature, this review consolidates the method ologies and assessment parameters for establishing immunosuppressive sepsis models. By critically evaluating the strengths and limitations of each approach, the review aims to establish a standardized experimental framework for the future development of optimized sepsis models.
PDF
95
16
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
