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Development strategies for animal models of anticipatory nausea and vomiting
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Yuelian WANG, Ke JIANG, Mengting DONG, Xinyue ZHOU, Jiayu SHENG*
Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3) : 451 - 458
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Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3): 451-458
Development strategies for animal models of anticipatory nausea and vomiting
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Yuelian WANG, Ke JIANG, Mengting DONG, Xinyue ZHOU, Jiayu SHENG*
Affiliations
  • Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Published: 2026-03-30 doi: 10.3969/j.issn.1005-4847.2026.03.013
Outline
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Anticipatory nausea and vomiting (ANV) is a learned form of nausea and vomiting that occurs when chemotherapy-induced nausea and vomiting are inadequately controlled. Patients often develop nausea and vomiting prior to subsequent chemotherapy sessions, a phenomenon termed ANV, with the severity correlating positively with the patient's anxiety and depression levels. Although approximately 20% ~ 30% of patients develop ANV by the fourth chemotherapy cycle, current treatment options for ANV remain limited, highlighting the need to elucidate its pathogenesis, explore effective therapies, and develop novel pharmacological agents. The establishment of ANV animal models plays an indispensable role in this process; however, no ideal preclinical model has yet fully and accurately replicated all features of ANV onset and progression observed in chemotherapy patients. This article systematically reviews recent advances in method ologies for establishing ANV animal models, including the selection of experimental species, common emetic agents, and protocols for modeling ANV in rats using lithium chloride. The review aims to provide references to aid the design of more precise animal models and to offer a foundation for further investigations into ANV mechanisms and potential drug development.

anticipatory nausea and vomiting  /  animal model  /  model establishment
Yuelian WANG, Ke JIANG, Mengting DONG, Xinyue ZHOU, Jiayu SHENG. Development strategies for animal models of anticipatory nausea and vomiting[J]. Acta Laboratorium Animalis Scientia Sinica, 2026 , 34 (3) : 451 -458 . DOI: 10.3969/j.issn.1005-4847.2026.03.013
Funding
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  • Shanghai Science and Technology Commission Medical Innovation Research Special Fund(23Y11921600)
  • Shanghai Municipal Health Commission Medical New Technology Research and Transformation Seed Program(2024ZZ2062)
  • Yueyang Hospital Institute of Translational Medicine Research Institute Fund(2024yyzh05)
  • Yueyang Hospital's Meritorious Service System Translational Medicine Institute-Level Fund(2024YJJB12)
Appendix
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Year 2026 volume 34 Issue 3
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123
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Article Info
doi: 10.3969/j.issn.1005-4847.2026.03.013
  • Receive Date：2025-04-08
  • Online Date：2026-08-08
  • Published：2026-03-30
Article Data
Affiliations
History
  • Received：2025-04-08
Funding
Shanghai Science and Technology Commission Medical Innovation Research Special Fund(23Y11921600)
Shanghai Municipal Health Commission Medical New Technology Research and Transformation Seed Program(2024ZZ2062)
Yueyang Hospital Institute of Translational Medicine Research Institute Fund(2024yyzh05)
Yueyang Hospital's Meritorious Service System Translational Medicine Institute-Level Fund(2024YJJB12)
Affiliations
    Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

Corresponding:

SHENG Jiayu. E-mail:
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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