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Research progress on animal models of comorbid chronic obstructive pulmonary disease and pulmonary interstitial fibrosis
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Yu JIANG1, Yu DING1, Jianjian YU2, Lina FU2, Chengsen CAI2, Jun WANG2, *
Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3) : 442 - 450
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Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3): 442-450
Research progress on animal models of comorbid chronic obstructive pulmonary disease and pulmonary interstitial fibrosis
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Yu JIANG1, Yu DING1, Jianjian YU2, Lina FU2, Chengsen CAI2, Jun WANG2, *
Affiliations
  • 1.the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
  • 2.Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China
Published: 2026-03-30 doi: 10.3969/j.issn.1005-4847.2026.03.012
Outline
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Chronic obstructive pulmonary disease (COPD) and pulmonary interstitial fibrosis (PIF) are chronic pulmonary diseases that severely impair lung function. COPD combined with PIF (COPD-PIF) exacerbates lung-tissue damage, accelerates disease progression, and significantly worsens patient prognosis. However, the exact pathogenesis of COPD-PIF remains unclear, and effective treatment options are still lacking. Animal models have recently played a crucial role in elucidating the pathological mechanisms of COPD-PIF and facilitating new drug development. Current COPD models are primarily established by single-factor induction (such as cigarette smoke exposure or lipopolysaccharide injection) or multi-factor combination method, while PIF models mainly rely on bleomycin induction. The administration route (e. g., intratracheal instillation, aerosol inhalation, or intravenous injection) affects the stability and reproducibility of these models. Although various COPD-PIF animal models have been developed and utilized for research, challenges remain in establishing a standardized and reliable model that fully mimics human disease characteristics. Additionally, although the order in which COPD and PIF are induced may influence the pathological manifestations, there is no consensus in current studies. Further investigations into the pathogenesis of COPD-PIF and the identification of effective therapeutic strategies require more research focusing on optimizing modeling techniques, improving model stability and reproducibility, and developing animal models that better reflect the clinical characteristics of COPD-PIF. These efforts will contribute to advancing fundamental research and facilitating new drug development in this field.

chronic obstructive pulmonary disease  /  pulmonary interstitial fibrosis  /  chronic obstructive pulmonary disease combined with pulmonary interstitial fibrosis  /  animal model  /  modeling method
Yu JIANG, Yu DING, Jianjian YU, Lina FU, Chengsen CAI, Jun WANG. Research progress on animal models of comorbid chronic obstructive pulmonary disease and pulmonary interstitial fibrosis[J]. Acta Laboratorium Animalis Scientia Sinica, 2026 , 34 (3) : 442 -450 . DOI: 10.3969/j.issn.1005-4847.2026.03.012
Funding
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  • Traditional Chinese Medicine Science and Technology Project Co-Funded by the Department of Science and Technology of the National Administration of Traditional Chinese Medicine and the Shandong Provincial Health Commission(GZY-KJS-SD-2023-048)
  • Shandong Province Medical Health Science and Technology Project(202403020196)
  • Traditional Chinese Medicine Science and Technology Project of Shandong Province(Q-2023041)
Appendix
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Year 2026 volume 34 Issue 3
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97
17
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Article Info
doi: 10.3969/j.issn.1005-4847.2026.03.012
  • Receive Date：2025-04-03
  • Online Date：2026-08-08
  • Published：2026-03-30
Article Data
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History
  • Received：2025-04-03
Funding
Traditional Chinese Medicine Science and Technology Project Co-Funded by the Department of Science and Technology of the National Administration of Traditional Chinese Medicine and the Shandong Provincial Health Commission(GZY-KJS-SD-2023-048)
Shandong Province Medical Health Science and Technology Project(202403020196)
Traditional Chinese Medicine Science and Technology Project of Shandong Province(Q-2023041)
Affiliations
    1.the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
    2.Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China

Corresponding:

WANG Jun. E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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