Home Journals Articles Updates About
CN
image
收藏切换
Research progress on regulation of the prostate cancer immune microenvironment by monoamine oxidase A and B
收藏切换
PDF
Liting FANG1, 2, Yaohua HU2, Fang WANG3, Jumei ZHAO1, *, Changhong SHI2, *
Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3) : 432 - 441
Less
收藏切换
Acta Laboratorium Animalis Scientia Sinica | 2026, 34(3): 432-441
Research progress on regulation of the prostate cancer immune microenvironment by monoamine oxidase A and B
Full
Liting FANG1, 2, Yaohua HU2, Fang WANG3, Jumei ZHAO1, *, Changhong SHI2, *
Affiliations
  • 1.Medical College of Yan'an University, Yan'an 716000, China
  • 2.Laboratory Animal Center, the Air Force Medical University, Xi'an 710032, China
  • 3.Department of Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
Published: 2026-03-30 doi: 10.3969/j.issn.1005-4847.2026.03.011
Outline
收藏切换

Cancer-associated fibroblasts (CAFs) influence the progression and treatment of prostate cancer (PCa) by remodeling the tumor microenvironment (TME). Identifying the key molecular drivers of this remodeling is critical for advancing cancer research. The monoamine oxidase (MAO) family, comprising the subtypes MAOA and MAOB, is a group of mitochondrial outer membrane oxidases that regulate monoamine metabolism through oxidative deamination. Aberrant MAO expression is closely associated with PCa growth, invasion, metastasis, poor prognosis, and TME remodeling. This review, based on various animal models, systematically summarizes the biological roles of the distinct MAO subtypes in CAFs and their contributions to PCa pathogenesis. We further explore the potential of MAO inhibitors in combination therapies for PCa, focusing on their differential expression profiles and functional specificity. In addition, we propose precision diagnostic and therapeutic strategies targeting MAO subtypes, with the aim of identifying novel therapeutic targets for personalized PCa treatment.

prostate cancer  /  monoamine oxidase  /  cancer-associated fibroblasts  /  monoamine oxidase inhibitor
Liting FANG, Yaohua HU, Fang WANG, Jumei ZHAO, Changhong SHI. Research progress on regulation of the prostate cancer immune microenvironment by monoamine oxidase A and B[J]. Acta Laboratorium Animalis Scientia Sinica, 2026 , 34 (3) : 432 -441 . DOI: 10.3969/j.issn.1005-4847.2026.03.011
Funding
Less
  • National Natural Science Foundation of China(32270566)
Appendix
Less
Year 2026 volume 34 Issue 3
PDF
108
16
Cite this Article
BibTeX
Article Info
doi: 10.3969/j.issn.1005-4847.2026.03.011
  • Receive Date：2025-06-16
  • Online Date：2026-08-08
  • Published：2026-03-30
Article Data
Affiliations
History
  • Received：2025-06-16
Funding
National Natural Science Foundation of China(32270566)
Affiliations
    1.Medical College of Yan'an University, Yan'an 716000, China
    2.Laboratory Animal Center, the Air Force Medical University, Xi'an 710032, China
    3.Department of Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Corresponding:

ZHAO Jumei. E-mail:
SHI Changhong. E-mail:
References
Share
https://castjournals.cast.org.cn/joweb/zgsydwxb/EN/10.3969/j.issn.1005-4847.2026.03.011
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House