Article(id=1266414221748232739, tenantId=1146029695717560320, journalId=1264170164305018921, issueId=1264245505073668287, articleNumber=PA20260328_1A4fZI2D, orderNo=null, doi=10.16429/j.1009-7848.2026.01.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1737561600000, receivedDateStr=2025-01-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1779866279304, onlineDateStr=2026-05-27, pubDate=1769788800000, pubDateStr=2026-01-31, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1779866279303, onlineIssueDateStr=2026-05-27, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1779866279303, creator=admin, updateTime=1779866279303, updator=admin, issue=Issue{id=1264245505073668287, tenantId=1146029695717560320, journalId=1264170164305018921, year='2026', volume='26', issue='1', pageStart='null', pageEnd='null', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=0, articleOrder=1, issueType=-1, specialIssue=null, createTime=1779349216946, creator=ztmeta, updateTime=1779349216946, updator=ztmeta, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=140, endPage=151, ext={EN=ArticleExt(id=1266414227880305190, articleId=1266414221748232739, tenantId=1146029695717560320, journalId=1264170164305018921, language=EN, title=The Antioxidant and Anti-aging Mechanisms of Bovine Milk Derived Sphingomyelin on the Short and Long Term of Caenorhabditis elegans, columnId=null, journalTitle=Journal of Chinese Institute of Food Science and Technology, columnName=营养与功能, runingTitle=null, highlight=null, articleAbstract=Sphingomyelin (SM) is one of the most abundant polar lipids in breast milk. However， the effects of SM intake in the early stage of life on the short-term and long-term health of infants and young children are unclear. This article takes Caenorhabditis elegans (C. elegans) as a model organism to explore the effects of sphingomyelin intervention in early life on short-term and long-term antioxidant and anti-aging effects. By analyzing the antioxidant stress capacity， antioxidant enzyme activity， glutathione content， malondialdehyde content， lipofuscin content， ROS content， antioxidant and anti-aging related gene expression during the L4 and adult stages of C. elegans， the mechanism of SM action was elucidated. Reproductive experiments have shown that supplementing milk source SM at concentrations of 0.2 μg/mL (LG) and 20 μg/mL (HG) during infancy is safe. Compared with the CG group， the average and maximum lifespans of the HG group were significantly prolonged， significantly prolonged by 3.75 days and 5.67 days respectively， consistent with changes in ROS levels in larvae and adults， and the stress resistance ability of both larvae and adults was improved. In terms of antioxidant enzymes， the activity of SOD enzyme activity (P＜0.001) and CAT enzyme activity (P＜0.05) and the GSH content (P＜0.01) in HG group larvae were significantly increased， and milk derived SM could significantly reduce the content of MDA in larvae. In the long-term development of life， the content of lipofuscin in HG group decreased (P＜0.001)， and after intervention， the activity of SOD enzyme activity (P＜0.001) and CAT enzyme activity (P＜0.001) was also significantly increased， and after intervention， both GSH content (P＜0.001) and MDA level (P＜0.001) were increased and decreased. In addition， supplementing with milk derived SM during infancy can upregulate the sod-3 and nsy-1 genes in larvae， while adults enhance their antioxidant and anti-aging abilities by upregulating the relative expression of sod-3， ctl-1， and daf-16 genes. In summary， supplementing with a certain amount of bovine milk derived SM during childhood can simultaneously enhance antioxidant and anti-aging abilities in both the short and long term of life., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=null), CN=ArticleExt(id=1266414227616064037, articleId=1266414221748232739, tenantId=1146029695717560320, journalId=1264170164305018921, language=CN, title=牛乳源鞘磷脂对秀丽隐杆线虫生命近远期的抗氧化和抗衰老作用, columnId=null, journalTitle=中国食品学报, columnName=营养与功能, runingTitle=null, highlight=null, articleAbstract=鞘磷脂(SM)是母乳中含量较高的极性脂之一，然而在生命早期摄入SM对婴幼儿近远期健康的作用尚不清晰。本文以秀丽隐杆线虫为模式生物，探究SM干预生命早期对其近远期的抗氧化和抗衰老作用。采用不同浓度牛乳源SM干预线虫L1~L4时期，研究SM对线虫生殖能力、寿命的影响。分析线虫L4时期及成年期的抗氧化应激能力和抗氧化酶活力，谷胱甘肽含量、丙二醛含量、脂褐素含量、活性氧(ROS)含量以及抗氧化和抗衰老相关基因表达，解析SM的作用机制。生殖实验显示，对幼年线虫补充质量浓度为0.2 μg/mL(LG)和20 μg/mL(HG)的乳源SM是安全的。与对照组(CG)相比，HG组的平均寿命和最大寿命分别显著延长了3.75 d和5.67 d，与幼虫和成虫ROS含量变化一致；干预后同时提高了幼虫和成虫的应激抵抗能力。在抗氧化酶方面，HG组幼虫超氧化物歧化酶(SOD)酶活性(P＜0.001)、过氧化氢酶(CAT)酶活性(P＜0.05)和谷胱甘肽(GSH)含量(P＜0.01)均显著提高，且乳源SM能显著降低幼虫丙二醛(MDA)水平(P＜0.001)。在生命远期发展中，HG组脂褐素含量降低(P＜0.001)，SOD酶活性(P＜0.001)和CAT酶活性(P＜0.001)显著提高，干预后均提高了GSH含量(P＜0.001)，降低了MDA水平(P＜0.001)。此外，幼年补充乳源SM能上调幼虫sod-3、nsy-1基因，而成虫则通过上调sod-3、ctl-1、daf-16基因的相对表达来提高抗氧化和抗衰老能力。综上，线虫幼年期补充一定量的乳源SM，可同时提升生命近远期抗氧化和抗衰老能力。, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, 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