Article(id=1292440003565613126, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750089600000, receivedDateStr=2025-06-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1786071309223, onlineDateStr=2026-08-07, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1786071309223, onlineIssueDateStr=2026-08-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1786071309223, creator=13701087609, updateTime=1786071309223, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2875, endPage=2880, ext={EN=ArticleExt(id=1292440005318832199, articleId=1292440003565613126, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trail of oliceridine in elderly patients undergoing proximal femoral antirotation intramedullary nail internal fixation, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the efficacy and safety of oliceridine injection, a novel G protein-biased μ-opioid receptor agonist, compared with sufentanil injection, a traditional μ-opioid receptor agonist, during the perioperative period of proximal femoral nail antirotation (PFNA) internal fixation in elderly patients with intertrochanteric femoral fractures.
Methods A toal of 80 elderly patients with intertrochanteric femoral fractures scheduled for PFNA internal fixation from April 2024 to April 2025 were randomly divided into control group and treatment group. In the control group, sufentanil injection 0.3 μg·kg-1 was used for intraoperative induction, and patient-controlled intravenous analgesia (PCIA) after surgery consisted of sufentanil injection 1 μg·kg-1 plus flurbiprofen axetil injection 200 mg. In the treatment group, oliceridine injection 0.06 mg·kg-1 was used for intraoperative induction, and postoperative PCIA consisted of oliceridine injection 0.2 mg·kg-1 plus flurbiprofen axetil injection 200 mg. The time to first ambulation after surgery,15-item Quality of Recovery Scale (QoR-15) scores at 24 and 48 h after surgery, intraoperative hemodynamic changes, visual analogue scale (VAS) scores at 6, 12, 24 and 48 h after surgery and adverse drug reactions were compared between two groups.
Results Forty patients were enrolled in each group. For the primary outcome measures, the QoR-15 scores at 24 hours after surgery (T7) in the treatment group and the control group were (123.23±8.82) and (114.80±10.55) scores, respectively; the QoR-15 scores at 48 hours after surgery (T8) were (126.65±6.13) and (118.20±9.13) scores, respectively; the time to first ambulation after surgery were (43.53±4.44) and (46.83±4.13) hours, respectively. The differencs of above indexes between two groups were all statistically significant (all P<0.05). For the secondary outcome measures, no statistically significant differences were found between the two groups in intraoperative hemodynamic parameters or postoperative VAS pain scores within 48 hours after surgery (all P>0.05). The incidence of postoperative dizziness in the treatment group and control group was 7.50% (3 cases/40 cases) and 27.50% (11 cases/40 cases), respectively; the incidence of postoperative nausea and vomiting was 7.50% (3 cases/40 cases) and 25.00% (10 cases/40 cases), respectively; the incidence of postoperative constipation was 5.00% (2 cases/40 cases) and 20.00% (8 cases/40 cases), respectively; statistically significant differences were noted in the incidences of the above adverse reactions between the two groups (all P<0.05). However, the incidence of postoperative cognitive dysfunction was 2.50% (1 cases/40 cases) and 7.50% (3 cases/40 cases), respectively, with no statistically significant difference (P>0.05).
Conclusion In elderly patients undergoing PFNA internal fixation, oliceridine injection provides intraoperative hemodynamic stability and postoperative analgesic efficacy comparable to sufentanil injection. Moreover, it significantly reduces the incidence of opioid-related adverse reactions such as dizziness, nausea and vomiting, and constipation, shortens the time to first ambulation, improves the early postoperative quality of recovery, and facilitates enhanced recovery after surgery.
, authors=Pei-yang CHEN
1, Rong-rong CHEN
1, Dong-qing SHEN
1, Yuan-zhao ZHUANG
2, authorsList=Pei-yang CHEN, Rong-rong CHEN, Dong-qing SHEN, Yuan-zhao ZHUANG, authorCompany=null, correspAuthors=Yuan-zhao ZHUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292440006065418312, articleId=1292440003565613126, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=奥赛利定用于老年患者行防旋股骨近端髓内钉内固定术围术期的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨新型G蛋白偏向性μ受体激动剂奥赛利定注射液对比传统μ受体激动剂舒芬太尼注射液用于老年股骨转子间骨折患者行防旋股骨近端髓内钉（PFNA）内固定术围术期的效果及安全性。
方法 选取2024年4月至2025年4月拟行PFNA内固定术的老年股骨转子间骨折患者，随机分为对照组和试验组。对照组术中诱导采用舒芬太尼注射液0.3 μg·kg-1，术后自控静脉镇痛（PCIA）采用舒芬太尼注射液1 μg·kg-1+氟比洛芬酯注射液200 mg；试验组术中诱导采用奥赛利定注射液0.06 mg·kg-1，术后PCIA采用奥赛利定注射液0.2 mg·kg-1+氟比洛芬酯注射液200 mg。比较2组患者术后首次下床活动时间、术后24、48 h的15项恢复质量量表（QoR-15）评分、术中血流动力学指标、术后48h内疼痛视觉模拟评分（VAS）并进行安全性评价。
结果 对照组和试验组每组各纳入40例患者。试验组和对照组术后24 h（T7）的QoR-15评分分别为（123.23±8.82）和（114.80±10.55）分，术后48 h（T8）的QoR-15评分分别为（126.65±6.13）和（118.20±9.13）分，术后首次下床活动时间分别为（43.53±4.44）和（46.83±4.13）h，上述指标在2组间比较，在统计学上差异均有统计学意义（均P<0.05）。2组患者术中血流动力学指标及术后48h内疼痛VAS评分比较，在统计学上差异均无统计学意义（均P>0.05）。试验组和对照组术后头晕发生率分别为7.50%（3例/40例）和27.50%（11例/40例），恶心呕吐发生率分别为7.50%（3例/40例）和25.00%（10例/40例），便秘发生率分别为5.00%（2例/40例）和20.00%（8例/40例），上述不良反应发生率在2组间比较，在统计学上差异均有统计学意义（均P<0.05）；试验组和对照组术后认知障碍发生率分别为2.50%（1例/40例）和7.50%（3例/40例），在统计学上差异无统计学意义（P>0.05）。
结论 在老年PFNA内固定术患者中，奥赛利定注射液可提供与舒芬太尼注射液相当的术中血流动力学稳定性和术后镇痛效果，并能显著降低术后头晕、恶心呕吐、便秘等阿片类药物不良反应发生率，缩短术后首次下床时间，提高术后早期恢复质量，有助于促进术后快速康复。
, authors=陈培阳
1, 陈荣荣
1, 沈冬青
1, 庄渊钊
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陈培阳（1976-），副主任医师，主要从事围术期快速康复方面的临床工作和研究
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