Article(id=1292135571565081295, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.11.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1767888000000, receivedDateStr=2026-01-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998726979, onlineDateStr=2026-08-06, pubDate=1781625600000, pubDateStr=2026-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998726979, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998726979, creator=13701087609, updateTime=1785998726979, updator=13701087609, issue=Issue{id=1292135402790482407, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1781625600000', pubDateStr='2026-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785998686739, creator='13701087609', updateTime=1786014315540, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292200954833686587, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292200954833686588, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1610, endPage=1616, ext={EN=ArticleExt(id=1292135571791573712, articleId=1292135571565081295, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Mechanisms and research advances of single and compound traditional Chinese medicines in treating diabetic kidney disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Diabetic kidney disease (DKD), a common and severe complication of both type 1 and type 2 diabetes, has become the leading cause of chronic kidney disease and end-stage renal disease. Current clinical treatments for DKD mainly focus on glycemic control and renal function protection, but existing strategies still fail to effectively halt the progressive decline of renal function. Patients often eventually progress to renal failure accompanied by cardiovascular complications. The complexity of the pathophysiological mechanisms of DKD determines the limitations of single-target interventions and highlights the necessity of multi-pathway synergistic therapy. Studies have shown that traditional Chinese medicine monomers can exert effects through multiple pathways: they not only regulate disordered glucose and lipid metabolism and alleviate oxidative stress and mitochondrial dysfunction, but also inhibit inflammatory responses, modulate autophagy levels, antagonize apoptosis, and regulate the renin-angiotensin-aldosterone system. This article systematically reviews the recent research progress of traditional Chinese medicine monomers in the intervention of DKD, analyzes the current limitations and deficiencies, and prospects future development directions, so as to provide theoretical support for the research and development of novel therapeutic strategies for DKD.

, authors=Li-li WU, Yang XU, authorsList=Li-li WU, Yang XU, authorCompany=null, correspAuthors=Yang XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135572080980689, articleId=1292135571565081295, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药单体治疗糖尿病肾病的作用机制及研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

糖尿病肾病（DKD）作为1型和2型糖尿病的常见严重并发症，目前已成为慢性肾病及终末期肾病发病的首要诱因。临床针对DKD的治疗多以血糖控制、肾功能保护为核心，但现有治疗方案仍无法有效遏制肾功能进行性衰退，患者最终常进展至肾衰竭，并伴发心血管系统并发症。DKD病理机制的复杂性决定了单一靶点干预的局限性，也凸显了多条通路协同治疗的必要性。研究显示，中药单体可通过多条通路发挥作用，既能调节紊乱的糖脂代谢、减轻氧化应激与线粒体功能损伤，又能抑制炎症反应，调控细胞自噬水平，拮抗细胞凋亡，同时还可调节肾素-血管紧张素-醛固酮系统。本文就近年来中药单体干预DKD的相关研究进展进行系统梳理，分析当前研究存在的局限与不足，对未来发展方向进行展望，以期为DKD新型治疗策略的研究提供理论支撑。

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吴丽丽（1985-），女，主管中药师，主要从事临床中药学方面的工作和研究

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吴丽丽（1985-），女，主管中药师，主要从事临床中药学方面的工作和研究

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