Article(id=1292135509128671488, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.09.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1770048000000, receivedDateStr=2026-02-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998712093, onlineDateStr=2026-08-06, pubDate=1778947200000, pubDateStr=2026-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998712093, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998712093, creator=13701087609, updateTime=1785998712093, updator=13701087609, issue=Issue{id=1292135444850955150, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1778947200000', pubDateStr='2026-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998696767, creator='13701087609', updateTime=1786014392260, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201276780081469, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201276784275774, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1338, endPage=1344, ext={EN=ArticleExt(id=1292135509300637953, articleId=1292135509128671488, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on the mechanism of anesthetics in alleviating cerebral ischemia-reperfusion injury, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary neurological injury that occurs after blood flow is restored in patients with ischemic stroke, and its pathological process involves inflammatory cascade imbalance, mitochondrial energy metabolism disorders, calcium ion overload and oxidative stress, which significantly affects the recovery of postoperative neurological function. In recent years, studies have shown that a variety of commonly used anesthetic drugs such as sevoflurane, propofol and dexmedetomidine can exert neuroprotective effects in the perioperative period through multi-target and pathway-specific mechanisms, thereby effectively alleviating CIRI. This paper summarizes the pathway and clinical application evidence of anesthetic drugs on neuroinflammation, energy metabolism, cell death and other pathways to alleviate CIRI, aiming to provide theoretical basis and research ideas for the optimization of clinical anesthesia regimens and the formulation of neuroprotective regimens.

, authors=Yu-xin YUAN¹, Chen-yao SUN¹, Zhao-kai ZHANG¹, Ying-ze ZHANG², Sheng-nan ZHANG³, authorsList=Yu-xin YUAN, Chen-yao SUN, Zhao-kai ZHANG, Ying-ze ZHANG, Sheng-nan ZHANG, authorCompany=null, correspAuthors=Sheng-nan ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135509619405058, articleId=1292135509128671488, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=麻醉药物减轻脑缺血再灌注损伤机制研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

脑缺血再灌注损伤（CIRI）是指缺血性卒中患者在血流恢复后出现的一种继发性神经损伤，其病理过程涉及炎症级联反应失衡、线粒体能量代谢障碍、钙离子超载及氧化应激等环节，显著影响术后神经功能恢复。近年来研究显示，多种常用麻醉药物如七氟烷、丙泊酚、右美托咪定等可以通过多靶点和通路特异性机制在围术期发挥神经保护作用，从而有效减轻CIRI。本文总结了麻醉药物作用于神经炎症、能量代谢、细胞死亡等通路减轻CIRI的途径与临床应用证据，旨在为临床麻醉方案优化和神经保护方案的制定提供理论依据与研究思路。

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袁雨欣（2002-），女，本科生，主要从事脑血管疾病方面的研究

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袁雨欣（2002-），女，本科生，主要从事脑血管疾病方面的研究

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