Article(id=1292135483128172666, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.09.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1767715200000, receivedDateStr=2026-01-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998705893, onlineDateStr=2026-08-06, pubDate=1778947200000, pubDateStr=2026-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998705893, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998705893, creator=13701087609, updateTime=1785998705893, updator=13701087609, issue=Issue{id=1292135444850955150, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1778947200000', pubDateStr='2026-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998696767, creator='13701087609', updateTime=1786014392260, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201276780081469, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201276784275774, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1227, endPage=1231, ext={EN=ArticleExt(id=1292135484445184123, articleId=1292135483128172666, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of ruxolitinib combined with recombinant human erythropoietin in hemodialysis patients with renal anemia, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the application effect of roxadustat capsules combined with recombinant human erythropoietin (rHuEPO) for injection in hemodialysis patients with renal anemia.
Methods Patients with renal anemia undergoing hemodialysis were randomly divided into control group and treatment group using a random number table method. The control group received treatment with rHuEPO injection, intravenous injection of 120-150 IU·kg-1, 2-3 times a week; the treatment group was administered roxadustat capsules orally after meals (100 mg for patients weighing <60 kg, 120 mg for patients weighing ≥60 kg) on the basis of the control group, 3 times per week. Both groups were treated continuously for 3 months. Iron metabolism indicators, anemia indicators and inflammatory factors were compared between the two groups. Clinical efficacy and adverse drug reactions were also assessed.
Results A total of 148 patients were enrolled in this study, including 70 cases in treatment group and 68 cases in control group. After treatment, the overall clinical effective rates of treatment group and control group were 95.71% (67 cases/70 cases) and 83.82% (57 cases/68 cases), respectively, with a statistically significant difference (P<0.05). After treatment, the serum iron (SI) levels of treatment group and control group were (15.98±4.04) and (13.41±3.72) μmol·L-1, respectively; the transferrin saturation (TSAT) levels were (35.23±5.03)% and (29.38±4.94)%, respectively; the serum ferritin (SF) levels were (284.69±31.41) and (219.57±28.47) μg·L-1, respectively; the hemoglobin (Hb) levels were (97.57±11.16) and (91.09±9.84) g·L-1, respectively; the hematocrit (Hct) levels were (34.62±4.09)% and (28.34±3.47)%, respectively; the red blood cell (RBC) counts were (3.41±0.74) and (2.77±0.61)×1012·L-1, respectively; the interleukin-6 (IL-6) levels were (58.02±6.19) and (64.23±7.63) ng·L-1, respectively; and the tumor necrosis factor-α (TNF-α) levels were (111.02±12.54) and (120.63±15.29) ng·L-1, respectively. There were statistically significant differences in all the above indicators between treatment group and control group (all P<0.05). Adverse drug reactions in treatment group included dizziness, fever, elevated blood pressure, nausea and vomiting, diarrhea and abnormal liver function, while those in control group included dizziness, fever, elevated blood pressure, nausea and vomiting, diarrhea and abnormal liver function. The total incidence of adverse drug reactions in treatment and control groups were 17.14% (12 cases/70 cases) and 19.12% (13 cases/68 cases), respectively, with no statistically significant difference (P>0.05).
Conclusion Roxadustat capsules combined with rHuEPO solution for injection can improve iron metabolism and anemia status, reduce inflammatory factor levels, and do not increase the risk of adverse drug reactions in hemodialysis patients with renal anemia.
, authors=Yao QIN
1a, Hai-yang WANG
2, Tang-li YU
1b, Xue-bing ZHANG
3, Peng-fei LI
1a, authorsList=Yao QIN, Hai-yang WANG, Tang-li YU, Xue-bing ZHANG, Peng-fei LI, authorCompany=null, correspAuthors=Peng-fei LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135484763951228, articleId=1292135483128172666, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=罗沙司他联合重组人促红细胞生成素在肾性贫血血液透析患者中的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察罗沙司他胶囊联合注射用重组人促红细胞生成素（rHuEPO）在肾性贫血血液透析患者中的临床疗效及安全性。
方法 将肾性贫血血液透析患者按照随机数表法分为对照组和试验组。对照组接受rHuEPO注射液治疗，静脉注射120~150 IU·kg-1，每周2~3次；试验组在对照组基础上应用罗沙司他胶囊，餐后口服（体重<60 kg者每次100 mg，≥60 kg者每次120 mg），每周3次。2组均连续治疗3个月。比较2组的铁代谢指标、贫血指标及炎性因子水平，评估临床疗效并进行安全性评价。
结果 本研究共纳入148例患者，试验组70例，对照组68例。试验组和对照组的临床总有效率分别为95.71%（67例/70例）和83.82%（57例/68例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的血清铁（SI）分别为（15.98±4.04）和（13.41±3.72）μmol·L-1，转铁蛋白饱和度（TSAT）分别为（35.23±5.03）%和（29.38±4.94）%，血清铁蛋白（SF）分别为（284.69±31.41）和（219.57±28.47）μg·L-1，血红蛋白（Hb）分别为（97.57±11.16）和（91.09±9.84）g·L-1，血细胞比容（Hct）分别为（34.62±4.09）%和（28.34±3.47）%，红细胞计数（RBC）分别为（3.41±0.74）和（2.77±0.61）×1012·L-1，白细胞介素-6（IL-6）分别为（58.02±6.19）和（64.23±7.63）ng·L-1，肿瘤坏死因子-α（TNF-α）分别为（111.02±12.54）和（120.63±15.29）ng·L-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应有头晕、发热、血压升高、恶心呕吐、腹泻和肝功能异常，对照组有头晕、发热、血压升高、恶心呕吐、腹泻和肝功能异常。试验组和对照组的药物不良反应总发生率分别为17.14%（12例/70例）和19.12%（13例/68例），在统计学上差异无统计学意义（P>0.05）。
结论 罗沙司他胶囊联合rHuEPO注射液可以改善肾性贫血血液透析患者的铁代谢和贫血状况，降低炎性因子水平，且未增加药物不良反应风险。
, authors=秦垚
1a, 王海洋
2, 于唐丽
1b, 张雪冰
3, 李鹏飞
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秦垚（1988-），女，主治医师，主要从事肾内血液透析方面的临床工作和研究
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