Article(id=1292135452434264923, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.09.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1773244800000, receivedDateStr=2026-03-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998698576, onlineDateStr=2026-08-06, pubDate=1778947200000, pubDateStr=2026-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998698576, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998698576, creator=13701087609, updateTime=1785998698576, updator=13701087609, issue=Issue{id=1292135444850955150, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1778947200000', pubDateStr='2026-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998696767, creator='13701087609', updateTime=1786014392260, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201276780081469, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201276784275774, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1216, endPage=1220, ext={EN=ArticleExt(id=1292135452660757340, articleId=1292135452434264923, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of influencing factors of steady-state concentration/dose ratio of milnacipran based on therapeutic drug monitoring, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the influencing factors of the steady-state concentration/dose ratio (C/D) for milnacipran tablets based on therapeutic drug monitoring (TDM), with the goal of promoting individualized use of this medication.

Methods

Inpatients who underwent milnacipran TDM were included in this study. General information, including gender, age, body mass index (BMI) and serum creatinine levels were collected through the medical record system. Additionally, dosage and comedication data were recorded. The analysis of these data was conducted using SPSS 23.0.

Results

A total of 156 patients with steady-state concentrations determined by milnacipran TDM were included in the analysis. The steady-state concentration of milnacipran was found to be 95.52 (67.34, 126.97) ng·mL-1, C/D was 0.95 (0.71, 1.24) ng·mL-1·mg-1·d. Multiple linear regression analysis indicated that renal function statistically significantly influenced C/D (P<0.05). C/D ratio in patients with renal insufficiency and patients with normal insufficiency were 1.16 (0.79,1.50) and 0.92 (0.64,1.08) ng·mL-1·mg-1·d, with statisticaly significant difference (P<0.05).

Conclusion

The factors influencing milnacipran’s C/D are complex; therefore, for patients with renal insufficiency, regular monitoring of serum drug concentrations is recommended to ensure both safety and efficacy in its use.

, authors=Xiao-qian LAN1, 2, Hong-yan ZHUANG1, 2, Shuang BAO1, 2, Yan-nan ZANG1, 2, Fei JIA1, 2, Meng-xi NIU1, 2, Peng-fei LI1, 2, authorsList=Xiao-qian LAN, Hong-yan ZHUANG, Shuang BAO, Yan-nan ZANG, Fei JIA, Meng-xi NIU, Peng-fei LI, authorCompany=null, correspAuthors=Peng-fei LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135452920804189, articleId=1292135452434264923, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于治疗药物监测的米那普仑血药浓度剂量比的影响因素分析, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

本研究旨在研究米那普仑片稳态血药浓度/剂量比(C/D)的影响因素,促进米那普仑个体化合理用药。

方法

将接受米那普仑治疗药物监测(TDM)的所有住院患者纳入为研究对象,通过电子病历系统收集其性别、年龄、体质量指数(BMI)、血清肌酸酐值等基本资料及给药剂量、合并用药等药物治疗信息,通过SPSS 23.0软件进行数据统计分析。

结果

共纳入米那普仑TDM测得稳态血药浓度的患者156例,米那普仑稳态血药浓度为95.52(67.34,126.97)ng·mL-1,C/D值范围为0.95(0.71,1.24)ng·mL-1·mg-1·d。多重线性回归提示肾功能状态对C/D值的影响有统计学意义(P<0.05),肾功能不全患者和肾功能正常患者的C/D值分别为1.16(0.79,1.50)和0.92(0.64,1.08)ng·mL-1·mg-1·d,在统计学上差异有统计学意义(P<0.05)。

结论

米那普仑血药浓度影响因素较为复杂,对于肾功能不全患者可能需要酌情调整优化米那普仑给药方案,推荐血药浓度监测保证用药安全性和有效性。

, authors=兰晓倩1, 2, 庄红艳1, 2, 鲍爽1, 2, 臧彦楠1, 2, 贾菲1, 2, 牛梦溪1, 2, 李鹏飞1, 2, authorsList=兰晓倩, 庄红艳, 鲍爽, 臧彦楠, 贾菲, 牛梦溪, 李鹏飞, authorCompany=null, correspAuthors=李鹏飞, authorNote=

兰晓倩(1991-),女,主管药师,主要从事临床药学方面的工作和研究

, correspAuthorsNote=
李鹏飞,主任药师 Tel: (010)58340250 E-mail:
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基于治疗药物监测的米那普仑血药浓度剂量比的影响因素分析
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兰晓倩 1, 2 , 庄红艳 1, 2 , 鲍爽 1, 2 , 臧彦楠 1, 2 , 贾菲 1, 2 , 牛梦溪 1, 2 , 李鹏飞 1, 2
中国临床药理学杂志 | 临床与基础桥接研究 2026,42(9): 1216-1220
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中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (9) : 1216 -1220
基于治疗药物监测的米那普仑血药浓度剂量比的影响因素分析
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兰晓倩1, 2, 庄红艳1, 2, 鲍爽1, 2, 臧彦楠1, 2, 贾菲1, 2, 牛梦溪1, 2, 李鹏飞1, 2
作者信息
  • 1.首都医科大学 附属北京安定医院,国家精神疾病医学中心/精神心理疾病国家临床医学研究中心/精神疾病创新药智能研发北京市重点实验室,北京 100088
  • 2.慢病新药创制关键桥接技术北京市重点实验室,北京 100029
通讯作者:
李鹏飞,主任药师 Tel: (010)58340250 E-mail:
作者简介:

兰晓倩(1991-),女,主管药师,主要从事临床药学方面的工作和研究

Analysis of influencing factors of steady-state concentration/dose ratio of milnacipran based on therapeutic drug monitoring
Xiao-qian LAN1, 2, Hong-yan ZHUANG1, 2, Shuang BAO1, 2, Yan-nan ZANG1, 2, Fei JIA1, 2, Meng-xi NIU1, 2, Peng-fei LI1, 2
Affiliations
  • 1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders/National Clinical Research Center for Mental Disorders/National Center for Mental Disorders, Beijing Anding Hospital Afflicated to Capital Medical University, Beijing 100088, China
  • 2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100029, China
出版时间: 2026-05-17 doi: 10.13699/j.cnki.1001-6821.2026.09.003
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目的

本研究旨在研究米那普仑片稳态血药浓度/剂量比(C/D)的影响因素,促进米那普仑个体化合理用药。

方法

将接受米那普仑治疗药物监测(TDM)的所有住院患者纳入为研究对象,通过电子病历系统收集其性别、年龄、体质量指数(BMI)、血清肌酸酐值等基本资料及给药剂量、合并用药等药物治疗信息,通过SPSS 23.0软件进行数据统计分析。

结果

共纳入米那普仑TDM测得稳态血药浓度的患者156例,米那普仑稳态血药浓度为95.52(67.34,126.97)ng·mL-1,C/D值范围为0.95(0.71,1.24)ng·mL-1·mg-1·d。多重线性回归提示肾功能状态对C/D值的影响有统计学意义(P<0.05),肾功能不全患者和肾功能正常患者的C/D值分别为1.16(0.79,1.50)和0.92(0.64,1.08)ng·mL-1·mg-1·d,在统计学上差异有统计学意义(P<0.05)。

结论

米那普仑血药浓度影响因素较为复杂,对于肾功能不全患者可能需要酌情调整优化米那普仑给药方案,推荐血药浓度监测保证用药安全性和有效性。

米那普仑片  /  治疗药物监测  /  稳态血药浓度  /  影响因素  /  个体化用药
Objective

To investigate the influencing factors of the steady-state concentration/dose ratio (C/D) for milnacipran tablets based on therapeutic drug monitoring (TDM), with the goal of promoting individualized use of this medication.

Methods

Inpatients who underwent milnacipran TDM were included in this study. General information, including gender, age, body mass index (BMI) and serum creatinine levels were collected through the medical record system. Additionally, dosage and comedication data were recorded. The analysis of these data was conducted using SPSS 23.0.

Results

A total of 156 patients with steady-state concentrations determined by milnacipran TDM were included in the analysis. The steady-state concentration of milnacipran was found to be 95.52 (67.34, 126.97) ng·mL-1, C/D was 0.95 (0.71, 1.24) ng·mL-1·mg-1·d. Multiple linear regression analysis indicated that renal function statistically significantly influenced C/D (P<0.05). C/D ratio in patients with renal insufficiency and patients with normal insufficiency were 1.16 (0.79,1.50) and 0.92 (0.64,1.08) ng·mL-1·mg-1·d, with statisticaly significant difference (P<0.05).

Conclusion

The factors influencing milnacipran’s C/D are complex; therefore, for patients with renal insufficiency, regular monitoring of serum drug concentrations is recommended to ensure both safety and efficacy in its use.

milnacipran tablet  /  therapeutic drug monitoring  /  steady-state concentration  /  influencing factor  /  individualized medicine
兰晓倩, 庄红艳, 鲍爽, 臧彦楠, 贾菲, 牛梦溪, 李鹏飞. 基于治疗药物监测的米那普仑血药浓度剂量比的影响因素分析. 中国临床药理学杂志, 2026 , 42 (9) : 1216 -1220 . DOI: 10.13699/j.cnki.1001-6821.2026.09.003
Xiao-qian LAN, Hong-yan ZHUANG, Shuang BAO, Yan-nan ZANG, Fei JIA, Meng-xi NIU, Peng-fei LI. Analysis of influencing factors of steady-state concentration/dose ratio of milnacipran based on therapeutic drug monitoring[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (9) : 1216 -1220 . DOI: 10.13699/j.cnki.1001-6821.2026.09.003
  • 北京市医院管理中心“扬帆”计划医工结合培育基金资助项目(YGLX202537)
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2026年第42卷第9期
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doi: 10.13699/j.cnki.1001-6821.2026.09.003
  • 接收时间:2026-03-12
  • 首发时间:2026-08-06
  • 出版时间:2026-05-17
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  • 收稿日期:2026-03-12
基金
北京市医院管理中心“扬帆”计划医工结合培育基金资助项目(YGLX202537)
作者信息
    1.首都医科大学 附属北京安定医院,国家精神疾病医学中心/精神心理疾病国家临床医学研究中心/精神疾病创新药智能研发北京市重点实验室,北京 100088
    2.慢病新药创制关键桥接技术北京市重点实验室,北京 100029

通讯作者:

李鹏飞,主任药师 Tel: (010)58340250 E-mail:
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2种不同金属材料的力学参数

Family
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Number of
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种数
Number of
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种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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