Article(id=1292135445702398863, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.09.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1763913600000, receivedDateStr=2025-11-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998696971, onlineDateStr=2026-08-06, pubDate=1778947200000, pubDateStr=2026-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998696971, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998696971, creator=13701087609, updateTime=1785998696971, updator=13701087609, issue=Issue{id=1292135444850955150, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1778947200000', pubDateStr='2026-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998696767, creator='13701087609', updateTime=1786014392260, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201276780081469, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201276784275774, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1210, endPage=1215, ext={EN=ArticleExt(id=1292135446092469136, articleId=1292135445702398863, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A real-world study of coblopasvir hydrochloride plus sofosbuvir for chronic hepatitis C, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the efficacy and safety of a 12-week regimen of coblopasvir hydrochloride capsules combined with sofosbuvir tablets in patients with chronic hepatitis C (CHC).
Methods CHC patients who visited our hospital and received a 12-week regimen of coblopasvir hydrochloride capsules combined with sofosbuvir tablets were enrolled as the study subjects. All patients received oral coblopasvir hydrochloride capsules (60 mg) and sofosbuvir tablets (400 mg) once daily for 12 weeks. Some patients with genotype 3b additionally received ribavirin tablets for 12 weeks at a dose of 1 000 mg·d-1 for those weighing < 75 kg and 1 200 mg·d-1 for those weighing ≥ 75 kg. Hepatitis C virus (HCV) ribonucleic acid and relevant laboratory indicators were measured before and after treatment. The sustained virological response at 12 weeks post-treatment (SVR12) rate was observed in all patients. Changes in liver and renal function before and after treatment were compared, and safety was evaluated.
Results A total of 110 CHC patients were enrolled. After treatment, 97.27% (107 cases/110 cases) of patients achieved SVR12. Specifically, the SVR12 rate was 93.33% (14 cases/15 cases) in patients with decompensated cirrhosis, 92.86% (13 cases/14 cases) in patients with genotype 3b CHC, 87.50% (7 cases/8 cases) in patients with moderate-to-severe renal impairment, and 83.33% (5 cases/6 cases) in genotype 3b patients receiving ribavirin combination therapy. The alanine aminotransferase levels before and after treatment were 58.70 (31.85, 100.45) and 20.60 (13.30, 31.33) U·L-1, respectively; the aspartate aminotransferase levels were 52.75 (28.68, 82.13) and 23.30 (17.78, 33.73) U·L-1, respectively; the total bilirubin levels were 13.90 (9.60, 20.25) and 11.70 (8.78, 18.85) μmol·L-1, respectively; the albumin levels were 42.80 (38.10, 45.30) and 45.10 (42.13, 46.73) g·L-1, respectively. After treatment, the aforementioned indicators showed statistically significant differences compared to before treatment (P<0.05, P<0.001). The estimated glomerular filtration rates before and after treatment were 102.09 (87.66, 108.68) and 99.23 (84.00, 104.28) mL·min-1, respectively, with no statistically significant difference (P>0.05). The main adverse drug reactions were fatigue (6.36%), decreased appetite (4.55%), abdominal distension (1.82%) and abdominal pain (1.82%). The overall incidence of adverse drug reactions was 10.91% (12 cases/110 cases), and the incidence in patients with decompensated cirrhosis was 13.33% (2 cases/15 cases). No serious adverse drug reaction occurred.
Conclusion The 12-week regimen of coblopasvir hydrochloride capsules combined with sofosbuvir tablets demonstrated favorable efficacy and high safety in real-world CHC patients, including those with genotype 3b, decompensated cirrhosis, or moderate-to-severe renal impairment.
, authors=Zun-ge WU
1, Wei DENG
1, Zhi-juan YANG
2, Chu-li XIAO
1, Wei-fang GUO
1, Yi-fan LI
1, Huan-qin HAN
1, authorsList=Zun-ge WU, Wei DENG, Zhi-juan YANG, Chu-li XIAO, Wei-fang GUO, Yi-fan LI, Huan-qin HAN, authorCompany=null, correspAuthors=Huan-qin HAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135447367537554, articleId=1292135445702398863, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=盐酸可洛派韦联合索磷布韦治疗慢性丙型肝炎的真实世界研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 评价盐酸可洛派韦胶囊联合索磷布韦片12周疗程在慢性丙型肝炎（CHC）中的疗效与安全性。
方法 本院就诊接受盐酸可洛派韦胶囊联合索磷布韦片12周治疗方案的CHC患者纳入为研究对象，所有患者接受盐酸可洛派韦胶囊（60 mg）以及索磷布韦片（400 mg）口服，每日1次，持续12周，部分基因3b型患者联合利巴韦林片（<75 kg者1 000 mg·d-1，≥ 75 kg者1 200 mg·d-1），持续12周。治疗前以及治疗后完善丙型肝炎病毒（HCV）核糖核酸及相关实验室指标检查，观察所有患者12周持续病毒学应答（SVR12）率，比较治疗前和治疗后肝功能、肾功能的变化并进行安全性评价。
结果 共纳入110例CHC患者。治疗后，SVR12率为97.27%（107例/110例），其中失代偿期肝硬化患者SVR12率为93.33%（14例/15例），基因3b型患者SVR12率为92.86%（13例/14例），合并中重度肾功能不全患者SVR12率为87.50%（7例/8例），联合利巴韦林治疗的基因3b型患者SVR12率为83.33%（5例/6例）。患者治疗前与治疗后的丙氨酸氨基转移酶分别为58.70（31.85，100.45）和20.60（13.30，31.33）U·L-1，天门冬氨酸氨基转移酶分别为52.75（28.68，82.13）和23.30（17.78，33.73）U·L-1，总胆红素分别为13.90（9.60，20.25）和11.70（8.78，18.85）μmol·L-1，白蛋白分别为42.80（38.10，45.30）和45.10（42.13，46.73）g·L-1，治疗后的上述指标与治疗前比较，在统计学上差异均有统计学意义（P<0.05，P<0.001）。患者治疗前与治疗后的估算肾小球滤过率分别为102.09（87.66，108.68）和99.23（84.00，104.28）mL·min-1，在统计学上差异无统计学意义（P>0.05）。患者药物不良反应主要有乏力（6.36%）、食欲减退（4.55%）、腹胀（1.82%）、腹痛（1.82%），总体药物不良反应发生率为10.91%（12例/110例），其中失代偿期肝硬化患者药物不良反应发生率为13.33%（2例/15例）。均无严重药物不良反应发生。
结论 盐酸可洛派韦胶囊联合索磷布韦片12周方案在真实世界CHC患者中，对包括基因3b型、合并失代偿期肝硬化或中重度肾功能不全在内的患者，疗效良好，安全性高。
, authors=吴尊格
1, 邓威
1, 杨智娟
2, 肖楚俐
1, 郭伟芳
1, 李一帆
1, 韩焕钦
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吴尊格（2000-），男，硕士研究生，主要从事传染性疾病方面的工作及研究
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