Article(id=1292135440962843391, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.11.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1765728000000, receivedDateStr=2025-12-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998695841, onlineDateStr=2026-08-06, pubDate=1781625600000, pubDateStr=2026-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998695841, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998695841, creator=13701087609, updateTime=1785998695841, updator=13701087609, issue=Issue{id=1292135402790482407, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1781625600000', pubDateStr='2026-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785998686739, creator='13701087609', updateTime=1786014315540, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292200954833686587, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292200954833686588, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1586, endPage=1589, ext={EN=ArticleExt(id=1292135441801704192, articleId=1292135440962843391, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Safety analysis of 0.01% atropine sulfate eye drops in myopia prevention and control among children and adolescents, columnId=1292126489844151289, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Adverse Drug Reactions, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the adverse drug reactions (ADRs) of 0.01% atropine sulfate eye drops in myopia control among children and adolescents, providing safety evidence for its clinical application.
Methods Retrospective analysis of ADR data from pediatric and adolescent patients using the 0.01% atropine sulfate eye drops (hospital-prepared formulation) in our institution from January 2022 to December 2024.
Results A total of 51 ADR cases were collected, with an incidence rate of 0.29%. Visual disorders were the most frequent (54.71%), primarily manifesting as eye pain, blurred vision, and photophobia; followed by skin and subcutaneous tissue disorders (11.76%), mainly presenting as rash; and nervous system disorders (9.80%), including dizzinessand headache. Newly reported ADRs accounted for 35 cases (68.63% of total reports). All ADRs were mild or moderate, with no severe cases observed.
Conclusion 0.01% atropine sulfate eye drops show favorable short-term safety and a low incidence of adverse drug reactions in myopia control among children and adolescents. As a real-world pharmacovigilance data report, this study provides certain cautions for the clinical use of 0.01% atropine sulfate eye drops; however, its long-term safety requires further investigation and validation.
, authors=Yin-ling ZHOU
1a, Lu-sheng WANG
1a, Meng-jie ZHOU
1a, Shan LIN
1b, Fang-fang XU
1b, Jian-li PAN
1a, Xiao-bi ZHANG
1b, authorsList=Yin-ling ZHOU, Lu-sheng WANG, Meng-jie ZHOU, Shan LIN, Fang-fang XU, Jian-li PAN, Xiao-bi ZHANG, authorCompany=null, correspAuthors=Xiao-bi ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135442556678913, articleId=1292135440962843391, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=0.01%硫酸阿托品滴眼液在儿童青少年近视防控中的安全性分析, columnId=1292126489986757627, journalTitle=中国临床药理学杂志, columnName=药物不良反应, runingTitle=null, highlight=null, articleAbstract=
目的 分析0.01%硫酸阿托品滴眼液在儿童青少年近视防控中的药物不良反应(ADR),为其临床应用提供安全性依据。
方法 回顾性分析2022年1月至2024年12月期间使用我院院内制剂0.01%硫酸阿托品滴眼液儿童青少年患者的ADR数据。
结果 收集ADR总计51例,发生率为0.29%,其中视觉疾病居首位(54.71%),主要表现为眼痛、视物模糊和畏光;其次为皮肤及皮肤附件疾病(11.76%),主要表现为皮疹;第3为神经系统疾病(9.80%),主要表现为头晕和头痛等。新的ADR总计35例,占总上报例数的68.63%。所有ADR均为轻度或中度,未出现严重ADR。
结论 0.01%硫酸阿托品滴眼液在儿童青少年近视防控中短期安全性较好,ADR发生率低。作为一项真实世界的药物警戒数据,本研究可为0.01%硫酸阿托品滴眼液临床用药提供一定警示,但其长期安全性仍需进一步研究验证。
, authors=周银玲
1a, 王璐晟
1a, 周梦洁
1a, 林珊
1b, 徐芳芳
1b, 潘建立
1a, 张晓碧
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周银玲(1988-),女,中药师,主要从事眼科临床药理研究
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