Article(id=1292135439855539045, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.11.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1757347200000, receivedDateStr=2025-09-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998695576, onlineDateStr=2026-08-06, pubDate=1781625600000, pubDateStr=2026-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998695576, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998695576, creator=13701087609, updateTime=1785998695576, updator=13701087609, issue=Issue{id=1292135402790482407, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1781625600000', pubDateStr='2026-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785998686739, creator='13701087609', updateTime=1786014315540, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292200954833686587, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292200954833686588, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1617, endPage=1623, ext={EN=ArticleExt(id=1292135440287552358, articleId=1292135439855539045, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on anti-aging mechanism of oleanolic acid, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid compound, is widely distributed in plants such as hawthorn and lycium barbarum. It possesses various biological activities including anti-inflammation, antioxidation, anti-tumor and anti-aging. In recent years, more and more studies have shown that OA can delay the aging process through multiple pathways, ①regulating oxidative stress response by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling 1 pathway to enhance the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT), and reduce reactive oxygen species (ROS) accumulation; ②inhibiting inflammatory-related pathways, such as nuclear factor-kappa B (NF-κB) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, to lower the levels of pro-inflammatory factors, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) ; ③activating the silent mating type information regulation 2 homolog (SIRT1) / adenosine monophosphate-activated protein kinase (AMPK) pathway to improve mitochondrial function, promote autophagy, and delay cellular aging; ④regulating the senescence-associated secretory phenotype (SASP) and inhibiting the tumor protein p53 (p53)/cyclin-dependent kinase inhibitor 1A (p21) signaling pathway to reduce cell cycle arrest. This article reviews the multi-target anti-aging mechanism of OA and explores its potential application value, aiming to provide theoretical basis and new ideas for anti-aging research.

, authors=Shuai LI1a, Bai-he ZHANG1b, Jia-qi XIA1a, authorsList=Shuai LI, Bai-he ZHANG, Jia-qi XIA, authorCompany=null, correspAuthors=Jia-qi XIA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135440996389735, articleId=1292135439855539045, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=齐墩果酸抗衰老作用机制的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

齐墩果酸(OA)是一种天然存在的五环三萜类化合物,广泛分布于山楂、女贞子等植物中。具有抗炎、抗氧化、抗肿瘤等多种生物活性。近年来,越来越多研究表明,OA可以通过多种途径延缓衰老进程,①调控氧化应激反应,通过激活核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)信号通路增强抗氧化酶的活性,如超氧化物歧化酶(SOD)和过氧化氢酶(CAT),减少活性氧(ROS)积累;②抑制核因子κB(NF-κB)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体等炎症相关通路,降低白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等促炎因子水平;③激活沉默信息调节因子1(SIRT1)/腺苷酸活化蛋白激酶(AMPK)通路,改善线粒体功能,促进自噬,延缓细胞衰老;④调节衰老相关分泌表型(SASP),抑制抑癌蛋白p53(p53)/周期蛋白依赖性激酶抑制剂1A(p21)信号通路,减少细胞周期阻滞。本文综述了OA抗衰老活性及其多靶点作用机制,并探讨其潜在应用价值,旨在为抗衰老研究提供理论依据和新思路。

, authors=李帅1a, 张百合1b, 夏佳琪1a, authorsList=李帅, 张百合, 夏佳琪, authorCompany=null, correspAuthors=夏佳琪, authorNote=

李帅(1994-),男,硕士研究生,主要从事肿瘤分子机制相关的研究

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夏佳琪,副教授,硕士生导师 MP: 13260663259 E-mail:
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齐墩果酸抗衰老作用机制的研究现状
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李帅 1a , 张百合 1b , 夏佳琪 1a
中国临床药理学杂志 | 综述 2026,42(11): 1617-1623
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中国临床药理学杂志 |综述 2026 , 42 (11) : 1617 -1623
齐墩果酸抗衰老作用机制的研究现状
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李帅1a, 张百合1b, 夏佳琪1a
作者信息
  • 1a.佳木斯大学 基础医学院,黑龙江 佳木斯 154000
  • 1b.佳木斯大学 临床医学院,黑龙江 佳木斯 154000
通讯作者:
夏佳琪,副教授,硕士生导师 MP: 13260663259 E-mail:
作者简介:

李帅(1994-),男,硕士研究生,主要从事肿瘤分子机制相关的研究

Research status on anti-aging mechanism of oleanolic acid
Shuai LI1a, Bai-he ZHANG1b, Jia-qi XIA1a
Affiliations
  • 1a.School of Basic Medical Sciences, Jiamusi University, Jiamusi 154000, Heilongjiang Province, China
  • 1b.School of Clinical Medicine, Jiamusi University, Jiamusi 154000, Heilongjiang Province, China
出版时间: 2026-06-17 doi: 10.13699/j.cnki.1001-6821.2026.11.019
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齐墩果酸(OA)是一种天然存在的五环三萜类化合物,广泛分布于山楂、女贞子等植物中。具有抗炎、抗氧化、抗肿瘤等多种生物活性。近年来,越来越多研究表明,OA可以通过多种途径延缓衰老进程,①调控氧化应激反应,通过激活核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)信号通路增强抗氧化酶的活性,如超氧化物歧化酶(SOD)和过氧化氢酶(CAT),减少活性氧(ROS)积累;②抑制核因子κB(NF-κB)、核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体等炎症相关通路,降低白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等促炎因子水平;③激活沉默信息调节因子1(SIRT1)/腺苷酸活化蛋白激酶(AMPK)通路,改善线粒体功能,促进自噬,延缓细胞衰老;④调节衰老相关分泌表型(SASP),抑制抑癌蛋白p53(p53)/周期蛋白依赖性激酶抑制剂1A(p21)信号通路,减少细胞周期阻滞。本文综述了OA抗衰老活性及其多靶点作用机制,并探讨其潜在应用价值,旨在为抗衰老研究提供理论依据和新思路。

齐墩果酸  /  抗衰老  /  氧化应激  /  炎症  /  自噬  /  多靶点

Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid compound, is widely distributed in plants such as hawthorn and lycium barbarum. It possesses various biological activities including anti-inflammation, antioxidation, anti-tumor and anti-aging. In recent years, more and more studies have shown that OA can delay the aging process through multiple pathways, ①regulating oxidative stress response by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling 1 pathway to enhance the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT), and reduce reactive oxygen species (ROS) accumulation; ②inhibiting inflammatory-related pathways, such as nuclear factor-kappa B (NF-κB) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, to lower the levels of pro-inflammatory factors, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) ; ③activating the silent mating type information regulation 2 homolog (SIRT1) / adenosine monophosphate-activated protein kinase (AMPK) pathway to improve mitochondrial function, promote autophagy, and delay cellular aging; ④regulating the senescence-associated secretory phenotype (SASP) and inhibiting the tumor protein p53 (p53)/cyclin-dependent kinase inhibitor 1A (p21) signaling pathway to reduce cell cycle arrest. This article reviews the multi-target anti-aging mechanism of OA and explores its potential application value, aiming to provide theoretical basis and new ideas for anti-aging research.

oleanolic acid  /  anti-aging  /  oxidative stress  /  inflammation  /  autophagy  /  multi-target
李帅, 张百合, 夏佳琪. 齐墩果酸抗衰老作用机制的研究现状. 中国临床药理学杂志, 2026 , 42 (11) : 1617 -1623 . DOI: 10.13699/j.cnki.1001-6821.2026.11.019
Shuai LI, Bai-he ZHANG, Jia-qi XIA. Research status on anti-aging mechanism of oleanolic acid[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (11) : 1617 -1623 . DOI: 10.13699/j.cnki.1001-6821.2026.11.019
  • 黑龙江省省属本科高校基本科研业务费科研项目基金资助项目(2024-KYYWF-0597)
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doi: 10.13699/j.cnki.1001-6821.2026.11.019
  • 接收时间:2025-09-09
  • 首发时间:2026-08-06
  • 出版时间:2026-06-17
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  • 收稿日期:2025-09-09
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黑龙江省省属本科高校基本科研业务费科研项目基金资助项目(2024-KYYWF-0597)
作者信息
    1a.佳木斯大学 基础医学院,黑龙江 佳木斯 154000
    1b.佳木斯大学 临床医学院,黑龙江 佳木斯 154000

通讯作者:

夏佳琪,副教授,硕士生导师 MP: 13260663259 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.11.019
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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