Article(id=1292135425926259277, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.10.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769961600000, receivedDateStr=2026-02-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998692255, onlineDateStr=2026-08-06, pubDate=1779897600000, pubDateStr=2026-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998692255, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998692255, creator=13701087609, updateTime=1785998692255, updator=13701087609, issue=Issue{id=1292135425250976333, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='10', pageStart='1351', pageEnd='1500', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998692095, creator='13701087609', updateTime=1786014373634, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201198489202995, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201198489202996, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1439, endPage=1442, ext={EN=ArticleExt(id=1292135426295358030, articleId=1292135425926259277, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A case analysis of liposomal amphotericin B treatment for candida meningitis in an extremely preterm infant, columnId=1246531412023730850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Medication Comment, runingTitle=null, highlight=null, articleAbstract=

A female preterm infant, 18 days old with a birth weight of 890 g, was hospitalized for respiratory distress that had persisted for 18 days following birth at a gestational age of 25 weeks and 6 days. Empirical antibacterial therapy at an outside hospital was ineffective, and a blood culture was positive for Candida albicans. Despite six days of fluconazole treatment, her condition showed no improvement. Upon transfer to our hospital, she received initial therapy with caspofungin combined with meropenem for one week. However, follow-up blood culture remained positive, and cerebrospinal fluid (CSF) analysis revealed an elevated white blood cell count. Cerebrospinal fluid metagenomic next-generation sequencing (mNGS) confirmed Candida albicans infection. With the involvement of a clinical pharmacist in the treatment team, the antimicrobial regimen was adjusted to liposomal amphotericin B combined with fluconazole. After 5 days of this adjusted therapy, the CSF white blood cell count decreased significantly. Two weeks later, CSF parameters showed marked improvement and the blood culture turned negative, although a progressive decline in platelet count was observed during monitoring. The clinical pharmacist subsequently assisted in formulating a de-escalation treatment plan, with a total therapy duration of 7 weeks. Ultimately, the infant was cured and discharged. This case suggests that liposomal amphotericin B is an effective agent for treating Candida meningitis in extremely preterm infants, although its adverse effects require close monitoring during therapy. Clinical pharmacists, by collaboratively formulating treatment plans, play a crucial role in ensuring both anti-infective efficacy and medication safety for critically ill, extremely preterm infants.

, authors=Hai-jing LI^1a, Na JIANG^1a, Ji-feng YE^1b, authorsList=Hai-jing LI, Na JIANG, Ji-feng YE, authorCompany=null, correspAuthors=Ji-feng YE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135426714788431, articleId=1292135425926259277, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=1例两性霉素B脂质体治疗超早产儿白色念珠菌性脑膜炎的病例分析, columnId=1246531412271194800, journalTitle=中国临床药理学杂志, columnName=用药点评, runingTitle=null, highlight=null, articleAbstract=

1例18天早产儿，女，因胎龄25周+6，早产后呼吸费力18天就诊。患儿出生体质量890 g，外院经验性抗细菌治疗效果欠佳，血培养提示白色念珠菌生长，予氟康唑治疗6天后仍无好转，转入本院。初始予卡泊芬净联合美罗培南治疗1周，复查血培养仍阳性，脑脊液白细胞升高，脑脊液病原微生物高通量基因检测报告为白色念珠菌感染，临床药师参与治疗团队，调整为两性霉素Ｂ脂质体联合氟康唑治疗。治疗5天脑脊液白细胞计数显著下降，治疗2周后脑脊液明显好转、血培养转阴，监测血小板计数进行性下降。临床药师协助制定降阶梯治疗方案，总疗程7周。最终患儿治愈出院。本案例提示，两性霉素B脂质体是治疗超早产儿念珠菌性脑膜炎的有效药物，临床药师共同制定治疗方案，在保障危重超早产儿抗感染疗效与用药安全中具有重要作用。

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李海静（1979-），女，主治医师，主要从事新生儿科诊疗工作

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李海静（1979-），女，主治医师，主要从事新生儿科诊疗工作

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