Article(id=1292130469223621351, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.05.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769443200000, receivedDateStr=2026-01-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997510485, onlineDateStr=2026-08-06, pubDate=1773676800000, pubDateStr=2026-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997510485, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997510485, creator=13701087609, updateTime=1785997510485, updator=13701087609, issue=Issue{id=1292130254689165893, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1773676800000', pubDateStr='2026-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997459337, creator='13701087609', updateTime=1786014469153, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201599108141219, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201599108141220, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=727, endPage=732, ext={EN=ArticleExt(id=1292130471295607529, articleId=1292130469223621351, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Prescription analysis and medication risk prevention and control of compound dextromethorphan hydrobromide syrup in pediatric outpatient and emergency departments, columnId=1291704944038536012, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Rational Use of Drugs, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the prescription rationality of compound dextromethorphan hydrobromide syrup and the review effectiveness of the rational drug use system in pediatric outpatient and emergency departments, clarify the key medication risk points and system shortcomings, and provide data support and practical evidence for optimizing the safety prevention and control process of pediatric medication.
Methods A retrospective study was conducted to collect prescriptions of compound dextromethorphan hydrobromide syrup in the outpatient and emergency departments of our hospital from January to December 2024. The mode of system screening combined with manual review was adopted, and an age-weight dual-dimensional evaluation criteria was established with reference to drug instructions and relevant clinical guidelines. The irrational prescriptions were classified and analyzed, and statistical analysis was performed using Excel 2010 and SPSS 23.0 software.
Results A total of 74 905 prescriptions of this preparation were issued throughout the year. System screening identified 527 positive irrational prescriptions, among which 357 were confirmed as true positive irrational prescriptions after manual review, with a system precision rate of 67.74% (357 prescriptions /527 prescriptions) and a false positive rate of 32.26% (170 prescriptions /527 prescriptions), and the overall irrational prescription rate was 0.48% (357 prescriptions /74 905 prescriptions). The core issues of irrational prescriptions primarily include drug interactions, duplicate medication, inappropriate dosage and administration, and unsuitable indications, accounting for 29.41% (105 prescriptions/357 prescriptions), 26.05% (93 prescriptions /357 prescriptions), 29.41% (105 prescriptions /357 prescriptions) and 16.81% (60 prescriptions /357 prescriptions), respectively. 98.24% (167 prescriptions /170 prescriptions) of false positive prescriptions were from overweight patients, indicating defects in the single-dimensional judgment logic of the system; the true positive rate of nighttime prescriptions 75.56% (250 prescriptions /357 prescriptions) was higher than 65.05% (255 prescriptions/392 prescriptions) of daytime prescriptions.
Conclusion The medication risks of compound dextromethorphan hydrobromide syrup in children are characterized by age concentration and vary among different age groups, and the rational drug use system has efficiency shortcomings. It is necessary to optimize the age-weight dual-dimensional judgment system, implement hierarchical prevention and control, source intervention and system upgrading, so as to effectively improve the level of pediatric medication safety, and provide reference for the clinical standardized management of this preparation and the optimization of rational drug use system.
, authors=Zhao-yang DU, Qiang SHI, Lei ZHANG, Zi-yang SONG, Jin-jing MA, Xin LIU, Xin-wei CHEN, Jing-hai WEI, Peng GUO, authorsList=Zhao-yang DU, Qiang SHI, Lei ZHANG, Zi-yang SONG, Jin-jing MA, Xin LIU, Xin-wei CHEN, Jing-hai WEI, Peng GUO, authorCompany=null, correspAuthors=Peng GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130472033805034, articleId=1292130469223621351, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=儿童门急诊复方氢溴酸右美沙芬糖浆处方分析及用药风险防控研究, columnId=1291704944210502478, journalTitle=中国临床药理学杂志, columnName=合理用药, runingTitle=null, highlight=null, articleAbstract=
目的 探讨儿童门急诊复方氢溴酸右美沙芬糖浆处方合理性及合理用药系统审核效能，明确用药风险点及系统短板，为优化儿童用药安全防控流程提供数据支撑与实践依据。
方法 回顾性收集2024年1月至12月本院门急诊复方氢溴酸右美沙芬糖浆处方，用“合理用药系统机筛+人工复核”模式，参照药品说明书及相关临床指南构建“年龄-体质量”双维度评价标准，对不合理处方进行分类分析，用Excel 2010和SPSS 23.0软件进行统计学分析。
结果 全年共开具该制剂处方74 905张，机筛阳性不合理处方527张，经人工复核确定真阳性不合理处方357张，系统精确率为67.74%（357张/527张），假阳性率为32.26%（170张/527张），总体处方不合理率为0.48%（357张/74 905张）。不合理处方集中于幼儿和学龄前儿童，占69.47%，（248张/357张）。不合理处方的核心问题主要为药物相互作用、重复用药、用法用量不适宜及适应症不适宜4大类，所占比例分别为29.41%（105张/357张）、26.05%（93张/357张）、29.41%（105张/357张）和16.81%（60张/357张）。98.24%（167张/170张）假阳性处方为超重患者，系统单维度判定逻辑存在缺陷；夜间处方真阳性率为75.56%（250张/357张）显著高于日间的65.05%（255张/392张）。
结论 复方氢溴酸右美沙芬糖浆儿童用药风险呈年龄集中特征且不同年龄段风险各异，合理用药系统存在效能短板，需优化“年龄-体质量”双维度判定体系并实施分层防控、源头干预、系统升级，切实提升儿童用药安全水平，为该制剂临床规范化管理及合理用药系统优化提供参考。
, authors=杜朝阳, 史强, 张雷, 宋子扬, 马津京, 刘新, 陈鑫伟, 魏京海, 郭鹏, authorsList=杜朝阳, 史强, 张雷, 宋子扬, 马津京, 刘新, 陈鑫伟, 魏京海, 郭鹏, authorCompany=null, correspAuthors=郭鹏, authorNote=
杜朝阳（1991-），女，主管药师，主要从事儿科临床药学研究和工作
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