Article(id=1292130424805938115, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.06.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1775059200000, receivedDateStr=2026-04-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997499895, onlineDateStr=2026-08-06, pubDate=1774627200000, pubDateStr=2026-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997499895, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997499895, creator=13701087609, updateTime=1785997499895, updator=13701087609, issue=Issue{id=1292130360968630762, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1774627200000', pubDateStr='2026-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997484675, creator='13701087609', updateTime=1786014452071, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201527440068743, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201527440068744, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=873, endPage=878, ext={EN=ArticleExt(id=1292130426550768583, articleId=1292130424805938115, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=The current situation and prospect of clinical trials of boron neutron capture therapy in China, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Boron neutron capture therapy (BNCT) is an emerging precise tumor therapy, characterized by its ability to kill tumor cells while minimizing damage to normal tissues. In recent years, BNCT has made significant breakthroughs in the research of malignant tumor treatment. This article introduces the basic principles, treatment characteristics, and overseas clinical research status of BNCT, focuses on the current situation of clinical trials of BNCT in China, analyzes the problems existing in the clinical application, and looks forward to the future development prospects of BNCT, with the aim of providing reference for the high-quality development of China’s BNCT industry in the future.

, authors=Jing-long HE1, 2, Xin TONG2, 3, Jun LÜ2, 3, Yan-ru LIU1, Zhi-min YANG2, 3, authorsList=Jing-long HE, Xin TONG, Jun LÜ, Yan-ru LIU, Zhi-min YANG, authorCompany=null, correspAuthors=Zhi-min YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130426789843912, articleId=1292130424805938115, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中国硼中子俘获治疗临床试验开展情况与展望, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

硼中子俘获治疗(BNCT)是一种新兴的药械组合治疗技术,特点在于能在杀伤肿瘤细胞的同时减少对正常组织的损伤。近年来,BNCT在恶性肿瘤的治疗研究中取得了突破性发展。本文系统介绍了BNCT的基本原理、治疗特点与境外临床研发情况,重点介绍了当前中国BNCT临床试验的开展情况,并对当前BNCT临床应用中存在的问题及未来的发展前景进行展望,以期为未来中国BNCT事业的高质量发展提供参考。

, authors=贺敬龙1, 2, 仝昕2, 3, 吕俊2, 3, 刘艳茹1, 杨志敏2, 3, authorsList=贺敬龙, 仝昕, 吕俊, 刘艳茹, 杨志敏, authorCompany=null, correspAuthors=杨志敏, authorNote=

贺敬龙(1994-),男,主治医师、审评员,主要从事药物临床研究与评价工作

仝昕(1982-),女,主审审评员,主要从事药品临床审评工作

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杨志敏,高级评审员 Tel: (010)85242698 E-mail:
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中国硼中子俘获治疗临床试验开展情况与展望
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贺敬龙 1, 2 , 仝昕 2, 3 , 吕俊 2, 3 , 刘艳茹 1 , 杨志敏 2, 3
中国临床药理学杂志 | 综述 2026,42(6): 873-878
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中国临床药理学杂志 |综述 2026 , 42 (6) : 873 -878
中国硼中子俘获治疗临床试验开展情况与展望
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贺敬龙1, 2, 仝昕2, 3, 吕俊2, 3, 刘艳茹1, 杨志敏2, 3
作者信息
  • 1.国家药品监督管理局 药品审评检查大湾区分中心,广东 深圳 518000
  • 2.药品监管科学全国重点实验室,北京 102629
  • 3.国家药品监督管理局 药品审评中心,北京 100163
通讯作者:
杨志敏,高级评审员 Tel: (010)85242698 E-mail:
作者简介:

贺敬龙(1994-),男,主治医师、审评员,主要从事药物临床研究与评价工作

仝昕(1982-),女,主审审评员,主要从事药品临床审评工作

The current situation and prospect of clinical trials of boron neutron capture therapy in China
Jing-long HE1, 2, Xin TONG2, 3, Jun LÜ2, 3, Yan-ru LIU1, Zhi-min YANG2, 3
Affiliations
  • 1.Guangdong-Hong Kong-Macao Greater Bay Area Center for Drug Evaluation and Inspection of NMPA, Shenzhen 518000, Guangdong Province, China
  • 2.State Key Laboratory of Drug Regulatory Science, Beijing 102629, China
  • 3.Center for Drug Evaluation of NMPA, Beijing 100163, China
出版时间: 2026-03-28 doi: 10.13699/j.cnki.1001-6821.2026.06.019
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硼中子俘获治疗(BNCT)是一种新兴的药械组合治疗技术,特点在于能在杀伤肿瘤细胞的同时减少对正常组织的损伤。近年来,BNCT在恶性肿瘤的治疗研究中取得了突破性发展。本文系统介绍了BNCT的基本原理、治疗特点与境外临床研发情况,重点介绍了当前中国BNCT临床试验的开展情况,并对当前BNCT临床应用中存在的问题及未来的发展前景进行展望,以期为未来中国BNCT事业的高质量发展提供参考。

硼中子俘获治疗  /  临床试验  /  新药  /  高端医疗器械

Boron neutron capture therapy (BNCT) is an emerging precise tumor therapy, characterized by its ability to kill tumor cells while minimizing damage to normal tissues. In recent years, BNCT has made significant breakthroughs in the research of malignant tumor treatment. This article introduces the basic principles, treatment characteristics, and overseas clinical research status of BNCT, focuses on the current situation of clinical trials of BNCT in China, analyzes the problems existing in the clinical application, and looks forward to the future development prospects of BNCT, with the aim of providing reference for the high-quality development of China’s BNCT industry in the future.

boron neutron capture therapy  /  clinical trials  /  new drug  /  high-end medical equipment
贺敬龙, 仝昕, 吕俊, 刘艳茹, 杨志敏. 中国硼中子俘获治疗临床试验开展情况与展望. 中国临床药理学杂志, 2026 , 42 (6) : 873 -878 . DOI: 10.13699/j.cnki.1001-6821.2026.06.019
Jing-long HE, Xin TONG, Jun LÜ, Yan-ru LIU, Zhi-min YANG. The current situation and prospect of clinical trials of boron neutron capture therapy in China[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (6) : 873 -878 . DOI: 10.13699/j.cnki.1001-6821.2026.06.019
  • 药品监管科学全国重点实验室课题(2024SKLDRS0227)
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2026年第42卷第6期
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doi: 10.13699/j.cnki.1001-6821.2026.06.019
  • 接收时间:2026-04-02
  • 首发时间:2026-08-06
  • 出版时间:2026-03-28
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  • 收稿日期:2026-04-02
基金
药品监管科学全国重点实验室课题(2024SKLDRS0227)
作者信息
    1.国家药品监督管理局 药品审评检查大湾区分中心,广东 深圳 518000
    2.药品监管科学全国重点实验室,北京 102629
    3.国家药品监督管理局 药品审评中心,北京 100163

通讯作者:

杨志敏,高级评审员 Tel: (010)85242698 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.06.019
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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