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Article(id=1292130413883970407, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.05.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1763395200000, receivedDateStr=2025-11-18, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997497291, onlineDateStr=2026-08-06, pubDate=1773676800000, pubDateStr=2026-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997497291, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997497291, creator=13701087609, updateTime=1785997497291, updator=13701087609, issue=Issue{id=1292130254689165893, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1773676800000', pubDateStr='2026-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997459337, creator='13701087609', updateTime=1786014469153, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201599108141219, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201599108141220, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=733, endPage=738, ext={EN=ArticleExt(id=1292130414114657128, articleId=1292130413883970407, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of severe cutaneous adverse drug reactions and potential mechanisms related to commonly used anti influenza virus drugs based on FAERS database combined with network pharmacology, columnId=1292126489844151289, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Adverse Drug Reactions, runingTitle=null, highlight=null, articleAbstract=
Objective

To extract severe cutaneous adverse reactions (SCAR) associated with commonly used anti-influenza virus drugs from the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) database, analyze the epidemiological characteristics of SCAR to provide a reference for safe clinical medication, and explore the underlying molecular mechanisms using network pharmacology.

Methods

Reports from January 2004 to December 2024 in FAERS database were collected, in which oseltamivir, peramivir, zanamivir and baloxavir marboxil were the primary suspected drugs and SCAR was the preferred term (PT). The reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN) methods were used to mine and analyze adverse drug event (ADE) signals. Targets of commonly used anti-influenza virus drugs and SCAR were extracted, a protein-protein interaction network was constructed, and enrichment analysis was performed.

Results

A total of 263 cases (1.90%) of SCAR related to commonly used anti-influenza virus drugs were collected. Females (55.13%) accounted for a higher proportion than males (35.36%). Positive signals were detected for all drugs except peramivir, with the association strength in descending order, baloxavir marboxil [n=42, ROR 1.75, information component(IC)0.8], zanamivir (n=53, ROR 1.61, IC 0.68) and oseltamivir (n=208, ROR 1.34, IC 0.42). The top 5 PT by frequency were blister, erythema multiforme, drug eruption, toxic epidermal necrolysis and acute generalized exanthematous pustulosis. Network pharmacology analysis showed that the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway may be a key pathway underlying SCAR induced by commonly used anti-influenza virus drugs.

Conclusion

Baloxavir marboxil, oseltamivir and zanamivir carry a risk of SCAR, with baloxavir marboxil and zanamivir showing higher signal intensity, while oseltamivir had the highest number of reports. Close monitoring of skin symptoms in female patients is recommended from 3 days after administration to guard against the occurrence of SCAR. Anti-influenza virus drugs may induce SCAR by regulating the JAK-STAT signaling pathway, which provides insights for further research.

, authors=Jing LIN1, 2, Shan-zi JIN3, Wen ZHANG1, Dong-na ZOU1, authorsList=Jing LIN, Shan-zi JIN, Wen ZHANG, Dong-na ZOU, authorCompany=null, correspAuthors=Dong-na ZOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130414370509673, articleId=1292130413883970407, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于FAERS数据库联合网络药理学分析常用抗流感病毒药物相关严重皮肤药物不良反应及潜在机制, columnId=1292126489986757627, journalTitle=中国临床药理学杂志, columnName=药物不良反应, runingTitle=null, highlight=null, articleAbstract=
目的

通过美国食品药品管理局（FDA）不良事件报告系统（FAERS）数据库，提取与常用抗流感病毒药物相关严重皮肤药物不良反应（SCAR），分析SCAR的流行病学特征，为临床安全用药提供参考；并运用网络药理学方法探讨其潜在分子机制。

方法

收集不良事件报告系统（FAERS）数据库中2004年1月至2024年12月，以玛巴洛沙韦、奥司他韦、帕拉米韦和扎那米韦为首要怀疑药品，以SCAR为首选术语（PT）的报告，用报告比值比法（ROR）和贝叶斯置信传播神经网络法（BCPNN）对风险信号进行挖掘分析。提取常用抗流感病毒药物和SCAR的靶点，构建蛋白相互作用网络，并进行富集分析。

结果

共收集263例（1.90%）常用抗流感病毒药物相关的SCAR，女性（55.13%）多于男性（35.36%）。除帕拉米韦外均生成阳性信号，关联度由强到弱依次是玛巴洛沙韦[n=42，ROR 1.75，信息成分值（IC）0.8]，扎那米韦（n=53，ROR 1.61，IC 0.68）和奥司他韦（n=208，ROR 1.34，IC 0.42）。阳性PT信号按频次排序前5位为水疱、多形性红斑、药疹、中毒性表皮坏死松解症和急性泛发性发疹性脓疱病。网络药理学研究显示，酪氨酸蛋白激酶-信号转导及转录激活因子（JAK-STAT）信号通路可能是常用抗流感病毒药物相关SCAR的关键通路。

结论

玛巴洛沙韦、奥司他韦和扎那米韦均有SCAR风险，其中玛巴洛沙韦和扎那米韦的信号强度较高，而奥司他韦的报告数量最多，用药3天后应密切关注女性患者皮肤症状，警惕SCAR的发生。抗流感病毒药物可能通过干预JAK-STAT信号通路导致SCAR，以期为后续进一步研究提供思路。

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林静（1990-），女，主管药师，主要从事医院药学及临床药学方面的研究和工作

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邹东娜，副主任药师，硕士生导师 Tel: （0531）58706621 E-mail:
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基于FAERS数据库联合网络药理学分析常用抗流感病毒药物相关严重皮肤药物不良反应及潜在机制
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林静 1, 2 , 金善子 3 , 张文 1 , 邹东娜 1
中国临床药理学杂志 | 药物不良反应 2026,42(5): 733-738
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中国临床药理学杂志 |药物不良反应 2026 , 42 (5) : 733 -738
基于FAERS数据库联合网络药理学分析常用抗流感病毒药物相关严重皮肤药物不良反应及潜在机制
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林静1, 2, 金善子3, 张文1, 邹东娜1
作者信息
  • 1.山东第一医科大学 附属省立医院 药学部，山东 济南 250021
  • 2.济南市市中区人民医院 药学部，山东 济南 250024
  • 3.济南市槐荫人民医院 药剂科，山东 济南 250021
通讯作者:
邹东娜，副主任药师，硕士生导师 Tel: （0531）58706621 E-mail:
作者简介:

林静（1990-），女，主管药师，主要从事医院药学及临床药学方面的研究和工作

Analysis of severe cutaneous adverse drug reactions and potential mechanisms related to commonly used anti influenza virus drugs based on FAERS database combined with network pharmacology
Jing LIN1, 2, Shan-zi JIN3, Wen ZHANG1, Dong-na ZOU1
Affiliations
  • 1.Department of Pharmacy, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shangdong Province, China
  • 2.Department of Pharmacy, Jinan Shizhong People’s Hospital, Jinan 250024, Shangdong Province, China
  • 3.Department of Pharmacy, The People’s Hospital Of Huaiyin, Jinan 250021, Shangdong Province, China
出版时间: 2026-03-17 doi: 10.13699/j.cnki.1001-6821.2026.05.021
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摘要
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目的

通过美国食品药品管理局（FDA）不良事件报告系统（FAERS）数据库，提取与常用抗流感病毒药物相关严重皮肤药物不良反应（SCAR），分析SCAR的流行病学特征，为临床安全用药提供参考；并运用网络药理学方法探讨其潜在分子机制。

方法

收集不良事件报告系统（FAERS）数据库中2004年1月至2024年12月，以玛巴洛沙韦、奥司他韦、帕拉米韦和扎那米韦为首要怀疑药品，以SCAR为首选术语（PT）的报告，用报告比值比法（ROR）和贝叶斯置信传播神经网络法（BCPNN）对风险信号进行挖掘分析。提取常用抗流感病毒药物和SCAR的靶点，构建蛋白相互作用网络，并进行富集分析。

结果

共收集263例（1.90%）常用抗流感病毒药物相关的SCAR，女性（55.13%）多于男性（35.36%）。除帕拉米韦外均生成阳性信号，关联度由强到弱依次是玛巴洛沙韦[n=42，ROR 1.75，信息成分值（IC）0.8]，扎那米韦（n=53，ROR 1.61，IC 0.68）和奥司他韦（n=208，ROR 1.34，IC 0.42）。阳性PT信号按频次排序前5位为水疱、多形性红斑、药疹、中毒性表皮坏死松解症和急性泛发性发疹性脓疱病。网络药理学研究显示，酪氨酸蛋白激酶-信号转导及转录激活因子（JAK-STAT）信号通路可能是常用抗流感病毒药物相关SCAR的关键通路。

结论

玛巴洛沙韦、奥司他韦和扎那米韦均有SCAR风险，其中玛巴洛沙韦和扎那米韦的信号强度较高，而奥司他韦的报告数量最多，用药3天后应密切关注女性患者皮肤症状，警惕SCAR的发生。抗流感病毒药物可能通过干预JAK-STAT信号通路导致SCAR，以期为后续进一步研究提供思路。

抗流感病毒药物  /  严重皮肤药物不良反应  /  美国食品药品管理局不良事件报告系统  /  药物警戒  /  网络药理学
Objective

To extract severe cutaneous adverse reactions (SCAR) associated with commonly used anti-influenza virus drugs from the US Food and Drug Administration (FDA) adverse event reporting system (FAERS) database, analyze the epidemiological characteristics of SCAR to provide a reference for safe clinical medication, and explore the underlying molecular mechanisms using network pharmacology.

Methods

Reports from January 2004 to December 2024 in FAERS database were collected, in which oseltamivir, peramivir, zanamivir and baloxavir marboxil were the primary suspected drugs and SCAR was the preferred term (PT). The reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN) methods were used to mine and analyze adverse drug event (ADE) signals. Targets of commonly used anti-influenza virus drugs and SCAR were extracted, a protein-protein interaction network was constructed, and enrichment analysis was performed.

Results

A total of 263 cases (1.90%) of SCAR related to commonly used anti-influenza virus drugs were collected. Females (55.13%) accounted for a higher proportion than males (35.36%). Positive signals were detected for all drugs except peramivir, with the association strength in descending order, baloxavir marboxil [n=42, ROR 1.75, information component(IC)0.8], zanamivir (n=53, ROR 1.61, IC 0.68) and oseltamivir (n=208, ROR 1.34, IC 0.42). The top 5 PT by frequency were blister, erythema multiforme, drug eruption, toxic epidermal necrolysis and acute generalized exanthematous pustulosis. Network pharmacology analysis showed that the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway may be a key pathway underlying SCAR induced by commonly used anti-influenza virus drugs.

Conclusion

Baloxavir marboxil, oseltamivir and zanamivir carry a risk of SCAR, with baloxavir marboxil and zanamivir showing higher signal intensity, while oseltamivir had the highest number of reports. Close monitoring of skin symptoms in female patients is recommended from 3 days after administration to guard against the occurrence of SCAR. Anti-influenza virus drugs may induce SCAR by regulating the JAK-STAT signaling pathway, which provides insights for further research.

anti-influenza virus drug  /  severe cutaneous adverse reaction  /  the US Food and Drug Administration adverse drug event reporting system  /  pharmacovigilance  /  network pharmacology
林静, 金善子, 张文, 邹东娜. 基于FAERS数据库联合网络药理学分析常用抗流感病毒药物相关严重皮肤药物不良反应及潜在机制. 中国临床药理学杂志, 2026 , 42 (5) : 733 -738 . DOI: 10.13699/j.cnki.1001-6821.2026.05.021
Jing LIN, Shan-zi JIN, Wen ZHANG, Dong-na ZOU. Analysis of severe cutaneous adverse drug reactions and potential mechanisms related to commonly used anti influenza virus drugs based on FAERS database combined with network pharmacology[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (5) : 733 -738 . DOI: 10.13699/j.cnki.1001-6821.2026.05.021
基金
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  • 白求恩慈善基金会基金资助项目(Z04JKM2023E040)
  • 山东省药学会学术课题基金资助项目(Kjyw2024-1)
  • 吴阶平医学基金会科研专项基金资助项目(320.6750.2023-26-16)
  • 山东省济南市卫生健康委员会科技计划基金资助项目(2025201009)
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doi: 10.13699/j.cnki.1001-6821.2026.05.021
  • 接收时间：2025-11-18
  • 首发时间：2026-08-06
  • 出版时间：2026-03-17
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  • 收稿日期：2025-11-18
基金
白求恩慈善基金会基金资助项目(Z04JKM2023E040)
山东省药学会学术课题基金资助项目(Kjyw2024-1)
吴阶平医学基金会科研专项基金资助项目(320.6750.2023-26-16)
山东省济南市卫生健康委员会科技计划基金资助项目(2025201009)
作者信息
    1.山东第一医科大学 附属省立医院 药学部，山东 济南 250021
    2.济南市市中区人民医院 药学部，山东 济南 250024
    3.济南市槐荫人民医院 药剂科，山东 济南 250021

通讯作者:

邹东娜，副主任药师，硕士生导师 Tel: （0531）58706621 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.05.021
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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