Article(id=1292130405684114036, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130366320562708, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.07.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769443200000, receivedDateStr=2026-01-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997495336, onlineDateStr=2026-08-06, pubDate=1776355200000, pubDateStr=2026-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997495336, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997495336, creator=13701087609, updateTime=1785997495336, updator=13701087609, issue=Issue{id=1292130366320562708, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1776355200000', pubDateStr='2026-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997485952, creator='13701087609', updateTime=1786014433453, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201449350516861, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130366320562708, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201449350516862, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130366320562708, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1002, endPage=1004, ext={EN=ArticleExt(id=1292130406149681781, articleId=1292130405684114036, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection, columnId=1246531412023730850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Medication Comment, runingTitle=null, highlight=null, articleAbstract=
Objective

To explore the efficacy of eravacycline combined with colistimethate sodium in treating sepsis caused by carbapenem-resistant Escherichia coli producing New Delhi metallo-β-lactamase (NDM) secondary to complex intra-abdominal infection.

Methods

The anti-infection regimen was dynamically adjusted according to abdominal-pelvic enhanced MRI, laboratory tests, changes in main inflammatory indicators (peripheral blood white blood cell count and procalcitonin), and drug sensitivity test results.

Results

After 13 days of treatment with eravacycline (50 mg, q12h) and colistimethate sodium (150 mg, q12h), the patient's condition and inflammatory indicators improved significantly, with no drug-related adverse reactions during hospitalization.

Conclusion

The combination is safe and effective for the above-mentioned sepsis, providing crucial technical support for clinical treatment of NDM-producing carbapenem-resistant Escherichia coli infections.

, authors=Hong CUI1a, Jun LI1a, Liang-kun JIANG1b, Jia-xi MA1b, Bo WANG1b, authorsList=Hong CUI, Jun LI, Liang-kun JIANG, Jia-xi MA, Bo WANG, authorCompany=null, correspAuthors=Hong CUI, Bo WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130406606860918, articleId=1292130405684114036, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=成功救治复杂性腹腔感染致碳青霉烯耐药大肠埃希菌脓毒症1例, columnId=1246531412271194800, journalTitle=中国临床药理学杂志, columnName=用药点评, runingTitle=null, highlight=null, articleAbstract=
目的

探讨依拉环素联合多黏菌素E甲磺酸钠治疗复杂性腹腔感染继发产新德里金属β-内酰胺酶(NDM)的碳青霉烯耐药大肠埃希菌脓毒症的疗效。

方法

根据腹盆增强核磁检查、实验室检查、主要炎症指标(外周血白细胞计数和降钙素原的变化)、药物敏感实验结果,动态调整抗感染方案。

结果

依拉环素(50 mg,q12h)联合多黏菌素E甲磺酸钠(150 mg,q12 h)治疗13天后,患者病情好转,炎症指标显著改善,住院期间未发生药物相关不良反应。

结论

依拉环素联合多黏菌素E甲磺酸钠治疗复杂性腹腔感染继发产NDM型金属酶碳青霉烯耐药大肠埃希菌所致的脓毒症安全有效,可为临床治疗产NDM型金属酶碳青霉烯耐药的大肠埃希菌感染提供关键的技术支持。

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崔洪(1966-),男,副主任医师,主要从事感染性疾病临床和科研工作

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汪波,主任医师,硕士生导师 Tel: (010)83572343 E-mail:
崔洪,副主任医师,硕士生导师 Tel: (010)83572014 E-mail:
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成功救治复杂性腹腔感染致碳青霉烯耐药大肠埃希菌脓毒症1例
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崔洪 1a , 李俊 1a , 姜良坤 1b , 马嘉蹊 1b , 汪波 1b
中国临床药理学杂志 | 用药点评 2026,42(7): 1002-1004
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中国临床药理学杂志 |用药点评 2026 , 42 (7) : 1002 -1004
成功救治复杂性腹腔感染致碳青霉烯耐药大肠埃希菌脓毒症1例
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崔洪1a , 李俊1a, 姜良坤1b, 马嘉蹊1b, 汪波1b
作者信息
  • 1a.北京大学第一医院,感染疾病科,北京 100034
  • 1b.北京大学第一医院,急诊科,北京 100034
通讯作者:
汪波,主任医师,硕士生导师 Tel: (010)83572343 E-mail:
崔洪,副主任医师,硕士生导师 Tel: (010)83572014 E-mail:
作者简介:

崔洪(1966-),男,副主任医师,主要从事感染性疾病临床和科研工作

A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection
Hong CUI1a , Jun LI1a, Liang-kun JIANG1b, Jia-xi MA1b, Bo WANG1b
Affiliations
  • 1a.Department of Infectious Diseases, First hospital of Peking University, Beijing 10034, China
  • 1b.Department of Emergency Medicine, First hospital of Peking University, Beijing 10034, China
出版时间: 2026-04-17 doi: 10.13699/j.cnki.1001-6821.2026.07.016
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目的

探讨依拉环素联合多黏菌素E甲磺酸钠治疗复杂性腹腔感染继发产新德里金属β-内酰胺酶(NDM)的碳青霉烯耐药大肠埃希菌脓毒症的疗效。

方法

根据腹盆增强核磁检查、实验室检查、主要炎症指标(外周血白细胞计数和降钙素原的变化)、药物敏感实验结果,动态调整抗感染方案。

结果

依拉环素(50 mg,q12h)联合多黏菌素E甲磺酸钠(150 mg,q12 h)治疗13天后,患者病情好转,炎症指标显著改善,住院期间未发生药物相关不良反应。

结论

依拉环素联合多黏菌素E甲磺酸钠治疗复杂性腹腔感染继发产NDM型金属酶碳青霉烯耐药大肠埃希菌所致的脓毒症安全有效,可为临床治疗产NDM型金属酶碳青霉烯耐药的大肠埃希菌感染提供关键的技术支持。

依拉环素  /  多黏菌素E甲磺酸钠  /  碳青霉烯耐药大肠埃希菌  /  脓毒症
Objective

To explore the efficacy of eravacycline combined with colistimethate sodium in treating sepsis caused by carbapenem-resistant Escherichia coli producing New Delhi metallo-β-lactamase (NDM) secondary to complex intra-abdominal infection.

Methods

The anti-infection regimen was dynamically adjusted according to abdominal-pelvic enhanced MRI, laboratory tests, changes in main inflammatory indicators (peripheral blood white blood cell count and procalcitonin), and drug sensitivity test results.

Results

After 13 days of treatment with eravacycline (50 mg, q12h) and colistimethate sodium (150 mg, q12h), the patient's condition and inflammatory indicators improved significantly, with no drug-related adverse reactions during hospitalization.

Conclusion

The combination is safe and effective for the above-mentioned sepsis, providing crucial technical support for clinical treatment of NDM-producing carbapenem-resistant Escherichia coli infections.

eravacycline hydrochloride for injection  /  colistimethate sodium for injection  /  carbapenem resistant Escherichia coli  /  sepsis
崔洪, 李俊, 姜良坤, 马嘉蹊, 汪波. 成功救治复杂性腹腔感染致碳青霉烯耐药大肠埃希菌脓毒症1例. 中国临床药理学杂志, 2026 , 42 (7) : 1002 -1004 . DOI: 10.13699/j.cnki.1001-6821.2026.07.016
Hong CUI, Jun LI, Liang-kun JIANG, Jia-xi MA, Bo WANG. A successfully treated case of carbapenem resistant Escherichia coli sepsis caused by complex intra-abdominal infection[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (7) : 1002 -1004 . DOI: 10.13699/j.cnki.1001-6821.2026.07.016

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2026年第42卷第7期
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doi: 10.13699/j.cnki.1001-6821.2026.07.016
  • 接收时间:2026-01-27
  • 首发时间:2026-08-06
  • 出版时间:2026-04-17
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  • 收稿日期:2026-01-27
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作者信息
    1a.北京大学第一医院,感染疾病科,北京 100034
    1b.北京大学第一医院,急诊科,北京 100034

通讯作者:

汪波,主任医师,硕士生导师 Tel: (010)83572343 E-mail:
崔洪,副主任医师,硕士生导师 Tel: (010)83572014 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.07.016
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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