Article(id=1292130379796861541, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130366320562708, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.07.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1773158400000, receivedDateStr=2026-03-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997489164, onlineDateStr=2026-08-06, pubDate=1776355200000, pubDateStr=2026-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997489164, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997489164, creator=13701087609, updateTime=1785997489164, updator=13701087609, issue=Issue{id=1292130366320562708, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1776355200000', pubDateStr='2026-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997485952, creator='13701087609', updateTime=1786014433453, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201449350516861, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130366320562708, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201449350516862, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130366320562708, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1011, endPage=1018, ext={EN=ArticleExt(id=1292130380195320422, articleId=1292130379796861541, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Semaglutide combined with metformin and Traditional Chinese Medicine in the treatment of obese polycystic ovary syndrome: An integrated perspective of Chinese and Western Medicine, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among women of childbearing age, with insulin resistance (IR) and abnormal glucose and lipid metabolism acting as the core driving factors in obese PCOS. Currently, Western medical therapies represented by metformin combined with glucagon-like peptide-1 receptor agonists (GLP-1RA) (such as semaglutide) have demonstrated definite efficacy in weight loss and IR improvement. However, they are limited by adverse gastrointestinal reactions and a high risk of weight rebound after drug withdrawal. Traditional Chinese Medicine (TCM) posits that the pathogenesis of this disease is characterized by "kidney deficiency as the root, spleen deficiency as the pivot, and phlegm-dampness and blood stasis as the branch." TCM possesses multi-target advantages in regulating body metabolism and reproductive endocrinology. Studies have shown that the synergistic application of TCM formulas combined with appropriate techniques, such as acupuncture and acupoint catgut embedding, alongside the aforementioned Western medicines, can not only further enhance weight loss and metabolic improvement by synergistically regulating key signaling pathways like adenosine 5′-monophosphate-activated protein kinase (AMPK) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), but also effectively optimize the ovarian microenvironment, improve endometrial receptivity, and significantly antagonize the gastrointestinal adverse reactions induced by Western medicines. This article systematically reviews the core mechanisms, evidence-based data, and safety profile of the combined treatment of metformin, semaglutide, and TCM for obese PCOS. It aims to provide a scientific theoretical basis for formulating standardized integrated Traditional Chinese and Western Medicine treatment protocols and offer new insights to break through the bottlenecks in the long-term clinical management of this disease.

, authors=Chun-you HUANG1, Yao-qi WEN2, Hai-yan MENG1, Bi-xia WANG1, Dan-hua QIU1, Hua-mei LI1, Xiao-li CHEN1, Ming-mei WANG1, Shao-yun LI1, Yu-guan WEN2, authorsList=Chun-you HUANG, Yao-qi WEN, Hai-yan MENG, Bi-xia WANG, Dan-hua QIU, Hua-mei LI, Xiao-li CHEN, Ming-mei WANG, Shao-yun LI, Yu-guan WEN, authorCompany=null, correspAuthors=Yu-guan WEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130381801738857, articleId=1292130379796861541, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=司美格鲁肽联合二甲双胍及中医药治疗肥胖型多囊卵巢综合征:中西医整合视角, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

多囊卵巢综合征(PCOS)是育龄期女性高发的内分泌代谢紊乱性疾病,其中肥胖型PCOS以胰岛素抵抗(IR)和糖脂代谢异常为核心驱动因素。当前以二甲双胍联合胰高血糖素样肽-1受体激动剂(GLP-1RA)(如司美格鲁肽)为代表的西医疗法在减重和改善IR方面疗效确切,但面临胃肠道不良反应及停药易反弹等局限。中医学(TCM)认为该病以“肾虚为本,脾虚为枢,痰湿瘀血为标”,中医药在调控机体代谢与生殖内分泌方面具有多靶点优势。研究表明,中药复方联合针刺、穴位埋线等适宜技术与上述西药协同应用,不仅能通过协同调控腺苷酸活化蛋白激酶(AMPK)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)等关键信号通路进一步强化减重与代谢改善疗效,还能有效优化卵巢微环境,提升子宫内膜容受性,并显著拮抗西药引发的胃肠道不良反应。本文系统梳理了二甲双胍、司美格鲁肽联合中医药治疗肥胖型PCOS的核心机制、循证证据及安全性,旨在为制定规范化的中西医整合治疗方案提供科学的理论依据,并为突破该病的临床长期管理瓶颈提供新思路。

, authors=黄春优1, 温耀祺2, 孟海燕1, 王碧霞1, 邱丹花1, 李华梅1, 陈小丽1, 王明媚1, 李少云1, 温预关2, authorsList=黄春优, 温耀祺, 孟海燕, 王碧霞, 邱丹花, 李华梅, 陈小丽, 王明媚, 李少云, 温预关, authorCompany=null, correspAuthors=温预关, authorNote=

黄春优(1983-),女,副主任中医师,主要从事妇产科疾病与药物评价方面的工作和研究

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温预关,主任药师,硕士生导师 Tel: (020)81268389 E-mail:
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司美格鲁肽联合二甲双胍及中医药治疗肥胖型多囊卵巢综合征:中西医整合视角
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黄春优 1 , 温耀祺 2 , 孟海燕 1 , 王碧霞 1 , 邱丹花 1 , 李华梅 1 , 陈小丽 1 , 王明媚 1 , 李少云 1 , 温预关 2
中国临床药理学杂志 | 综述 2026,42(7): 1011-1018
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中国临床药理学杂志 |综述 2026 , 42 (7) : 1011 -1018
司美格鲁肽联合二甲双胍及中医药治疗肥胖型多囊卵巢综合征:中西医整合视角
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黄春优1, 温耀祺2, 孟海燕1, 王碧霞1, 邱丹花1, 李华梅1, 陈小丽1, 王明媚1, 李少云1, 温预关2
作者信息
  • 1.广东省东莞市虎门医院 妇产科,广东 东莞 523900
  • 2.广州医科大学附属脑科医院 Ⅰ期临床研究室,广东 广州 510370
通讯作者:
温预关,主任药师,硕士生导师 Tel: (020)81268389 E-mail:
作者简介:

黄春优(1983-),女,副主任中医师,主要从事妇产科疾病与药物评价方面的工作和研究

Semaglutide combined with metformin and Traditional Chinese Medicine in the treatment of obese polycystic ovary syndrome: An integrated perspective of Chinese and Western Medicine
Chun-you HUANG1, Yao-qi WEN2, Hai-yan MENG1, Bi-xia WANG1, Dan-hua QIU1, Hua-mei LI1, Xiao-li CHEN1, Ming-mei WANG1, Shao-yun LI1, Yu-guan WEN2
Affiliations
  • 1.Department of Obstetrics and Gynecology, Humen Hospital of Dongguan City, Dongguan 523900, Guangdong Province, China
  • 2.Phase Ⅰ Clinical Research Laboratory, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, Guangdong Province, China
出版时间: 2026-04-17 doi: 10.13699/j.cnki.1001-6821.2026.07.018
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多囊卵巢综合征(PCOS)是育龄期女性高发的内分泌代谢紊乱性疾病,其中肥胖型PCOS以胰岛素抵抗(IR)和糖脂代谢异常为核心驱动因素。当前以二甲双胍联合胰高血糖素样肽-1受体激动剂(GLP-1RA)(如司美格鲁肽)为代表的西医疗法在减重和改善IR方面疗效确切,但面临胃肠道不良反应及停药易反弹等局限。中医学(TCM)认为该病以“肾虚为本,脾虚为枢,痰湿瘀血为标”,中医药在调控机体代谢与生殖内分泌方面具有多靶点优势。研究表明,中药复方联合针刺、穴位埋线等适宜技术与上述西药协同应用,不仅能通过协同调控腺苷酸活化蛋白激酶(AMPK)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)等关键信号通路进一步强化减重与代谢改善疗效,还能有效优化卵巢微环境,提升子宫内膜容受性,并显著拮抗西药引发的胃肠道不良反应。本文系统梳理了二甲双胍、司美格鲁肽联合中医药治疗肥胖型PCOS的核心机制、循证证据及安全性,旨在为制定规范化的中西医整合治疗方案提供科学的理论依据,并为突破该病的临床长期管理瓶颈提供新思路。

二甲双胍  /  司美格鲁肽  /  多囊卵巢综合征  /  肥胖  /  中西医结合  /  临床疗效  /  循证医学

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among women of childbearing age, with insulin resistance (IR) and abnormal glucose and lipid metabolism acting as the core driving factors in obese PCOS. Currently, Western medical therapies represented by metformin combined with glucagon-like peptide-1 receptor agonists (GLP-1RA) (such as semaglutide) have demonstrated definite efficacy in weight loss and IR improvement. However, they are limited by adverse gastrointestinal reactions and a high risk of weight rebound after drug withdrawal. Traditional Chinese Medicine (TCM) posits that the pathogenesis of this disease is characterized by "kidney deficiency as the root, spleen deficiency as the pivot, and phlegm-dampness and blood stasis as the branch." TCM possesses multi-target advantages in regulating body metabolism and reproductive endocrinology. Studies have shown that the synergistic application of TCM formulas combined with appropriate techniques, such as acupuncture and acupoint catgut embedding, alongside the aforementioned Western medicines, can not only further enhance weight loss and metabolic improvement by synergistically regulating key signaling pathways like adenosine 5′-monophosphate-activated protein kinase (AMPK) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), but also effectively optimize the ovarian microenvironment, improve endometrial receptivity, and significantly antagonize the gastrointestinal adverse reactions induced by Western medicines. This article systematically reviews the core mechanisms, evidence-based data, and safety profile of the combined treatment of metformin, semaglutide, and TCM for obese PCOS. It aims to provide a scientific theoretical basis for formulating standardized integrated Traditional Chinese and Western Medicine treatment protocols and offer new insights to break through the bottlenecks in the long-term clinical management of this disease.

metformin  /  semaglutide  /  polycystic ovary syndrome  /  obesity  /  Integrated traditional Chinese and Western Medicine  /  Clinical efficacy  /  Evidence-based medicine
黄春优, 温耀祺, 孟海燕, 王碧霞, 邱丹花, 李华梅, 陈小丽, 王明媚, 李少云, 温预关. 司美格鲁肽联合二甲双胍及中医药治疗肥胖型多囊卵巢综合征:中西医整合视角. 中国临床药理学杂志, 2026 , 42 (7) : 1011 -1018 . DOI: 10.13699/j.cnki.1001-6821.2026.07.018
Chun-you HUANG, Yao-qi WEN, Hai-yan MENG, Bi-xia WANG, Dan-hua QIU, Hua-mei LI, Xiao-li CHEN, Ming-mei WANG, Shao-yun LI, Yu-guan WEN. Semaglutide combined with metformin and Traditional Chinese Medicine in the treatment of obese polycystic ovary syndrome: An integrated perspective of Chinese and Western Medicine[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (7) : 1011 -1018 . DOI: 10.13699/j.cnki.1001-6821.2026.07.018
  • 重大疑难疾病中西医临床协作基金资助项目(国中医药综结合发[2024]3号)
  • 中华国际医学交流基金资助项目(Z-2014-08-2309-5)
  • 广东省医院药学研究基金扬子江基金资助项目(2025A01033)
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doi: 10.13699/j.cnki.1001-6821.2026.07.018
  • 接收时间:2026-03-11
  • 首发时间:2026-08-06
  • 出版时间:2026-04-17
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  • 收稿日期:2026-03-11
基金
重大疑难疾病中西医临床协作基金资助项目(国中医药综结合发[2024]3号)
中华国际医学交流基金资助项目(Z-2014-08-2309-5)
广东省医院药学研究基金扬子江基金资助项目(2025A01033)
作者信息
    1.广东省东莞市虎门医院 妇产科,广东 东莞 523900
    2.广州医科大学附属脑科医院 Ⅰ期临床研究室,广东 广州 510370

通讯作者:

温预关,主任药师,硕士生导师 Tel: (020)81268389 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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