Article(id=1292130375267021209, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.06.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997488085, onlineDateStr=2026-08-06, pubDate=1774627200000, pubDateStr=2026-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997488085, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997488085, creator=13701087609, updateTime=1785997488085, updator=13701087609, issue=Issue{id=1292130360968630762, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1774627200000', pubDateStr='2026-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997484675, creator='13701087609', updateTime=1786014452071, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201527440068743, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201527440068744, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=885, endPage=892, ext={EN=ArticleExt(id=1292130375455764890, articleId=1292130375267021209, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of rimegepant in migraine treatment, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Migraine is a highly disabling chronic disease that significantly affects patients’ quality of life. Conventional therapeutic drugs have limited application due to their insufficient efficacy, numerous contraindications and high risk of induce medication-overuse headache. With the in-depth research on the pathogenesis of migraine, the calcitonin gene-related peptide (CGRP) receptor has emerged as a noval target for the treatment and prevention of migraine. As a noval CGRP receptor antagonist, rimegepant was approved for marketing in China in 2024. Reserach has shown that rimegepant can simultaneously reduce the frequency of migraine attacks and the medication dosage in the acute phase. It is currently the first and only drug that can be used for both acute and preventive treatment of migraine, which makes up for the shortcomings of conventional therapeutic drugs. This article systematically reviews the research progress of rimegepant in the treatment of migraine, including its mechanism of action, pharmacokinetic characteristics, clinical trial, and safety evaluation, aiming to provide a evidence for the clinial treatment of migraine.

, authors=Wen-hui LIU^{1, 2}, Si-jie ZHANG^{1, 2}, Yan WANG², Si-qi OUYANG², Yong-liang ZHU², Dong-jun WAN², authorsList=Wen-hui LIU, Si-jie ZHANG, Yan WANG, Si-qi OUYANG, Yong-liang ZHU, Dong-jun WAN, authorCompany=null, correspAuthors=Dong-jun WAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130377561305499, articleId=1292130375267021209, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=瑞美吉泮治疗偏头痛的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

偏头痛是常见的高致残性慢性疾病，反复发作对患者的生活质量造成严重影响。常规治疗药物因疗效局限、禁忌症较多且易导致药物过度使用性头痛而使用受限。偏头痛病理机制的研究取得了显著进展，降钙素基因相关肽（CGRP）受体是防治偏头痛的新靶点。瑞美吉泮是新型的CGRP受体拮抗剂，于2024年获批在中国上市，研究发现瑞美吉泮能够同时降低偏头痛的发作频率，减少偏头痛急性期的药物用量，是目前首个且唯一可以用于急性期及预防性治疗偏头痛的药物，有效弥补了常规治疗药物的不足。本文综述瑞美吉泮治疗偏头痛的作用机制、药动学特征、临床试验及安全性评价等方面的研究进展，为临床治疗偏头痛提供依据。

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刘文会（2001-），女，硕士研究生，主要从事头痛相关疾病的研究

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刘文会（2001-），女，硕士研究生，主要从事头痛相关疾病的研究

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