Article(id=1292130357252481862, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.05.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750348800000, receivedDateStr=2025-06-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997483789, onlineDateStr=2026-08-06, pubDate=1773676800000, pubDateStr=2026-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997483789, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997483789, creator=13701087609, updateTime=1785997483789, updator=13701087609, issue=Issue{id=1292130254689165893, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1773676800000', pubDateStr='2026-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997459337, creator='13701087609', updateTime=1786014469153, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201599108141219, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201599108141220, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=630, endPage=635, ext={EN=ArticleExt(id=1292130357638357831, articleId=1292130357252481862, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial on the treatment of severe pneumonia with type Ⅰ respiratory failure in children by bromhexine hydrochloride combined with high-flow nasal cannula oxygen therapy, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of the application of bromhexine hydrochloride injection combined with high-flow nasal cannula oxygen therapy in children with severe pneumonia complicated with type I respiratory failure.
Methods Children with severe pneumonia complicated with type I respiratory failure who were treated in our hospital were collected and divided into control group and treatment group based on the treatment methods. The control group received conventional oxygen therapy on the basis of conventional treatment, while the treatment group was given bromhexine hydrochloride and glucose injection (2~4 mg each time, qd, intravenous drip) combined with high-flow nasal cannula oxygen therapy on the basis of conventional treatment. Both groups were treated for 7 days. The clinical efficacy, respiratory and circulatory indicators, and inflammatory indicators of the two groups were compared, and safety was evaluated.
Results A total of 94 children were included, including 49 in control group and 45 in treatment group. After treatment, the overall clinical response rates were 75.51% (37 cases/49 cases) in control group and 91.11% (41 cases /45 cases) in treatment group, demonstrating a statistically significant difference (P<0.05). After treatment, the arterial partial pressure of oxygen (PaO2) levels of control group and treatment group were (75.43±7.71) and (80.35±8.63) mmHg, respectively; the percutaneous oxygen saturation (SpO2) levels were (94.16±2.06)% and (95.31±2.33)%, respectively; the PaO2/FiO2 levels were 327.08±34.36 and 342.40±33.53, respectively; the respiratory rate (RR) levels were (30.16±3.39) and (28.33±3.03) time·min-1, respectively; the lactate levels were (2.66±0.43) and (2.38±0.34) mmol·L-1, respectively; the interleukin-6 (IL-6) levels were (14.45±3.37) and (12.64±3.31) pg·mL-1, respectively; the white blood cell (WBC) levels were (7.94±2.13) and (7.07±1.87) ×109·L-1, respectively; the neutrophil percentage (NEUT%) levels were (55.36±8.25)% and (51.58±7.43)%, respectively; the procalcitonin (PCT) levels were (0.17±0.04) and (0.15±0.04) ng·mL-1, respectively, all differences between the two groups were statistically significant (P<0.05, P<0.01). The main adverse drug reactions in control group were facial skin damage, nasal mucosa damage and abdominal distension; the main adverse drug reactions in treatment group were nausea, vomiting, facial skin damage and nasal mucosa damage. The total incidence of adverse drug reactions in control group and treatment group were 14.29% (7 cases/49 cases) and 11.11% (5 cases/45 cases), respectively, with no statistically significant difference (P>0.05).
Conclusion The treatment plan of bromhexine hydrochloride and glucose injection combined with high-flow nasal cannula oxygen therapy for children with severe pneumonia complicated with type Ⅰ respiratory failure is effective. It can significantly improve clinical symptoms, shorten the time of symptom relief, improve respiratory and circulatory indicators, reduce inflammatory indicators, promote the absorption of pneumonia, improve treatment comfort, shorten hospital stay and has good safety.
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目的 观察小儿重症肺炎合并Ⅰ型呼吸衰竭应用盐酸溴己新注射液联合高流量鼻导管氧疗治疗的临床疗效和安全性。
方法 将本院就诊的重症肺炎合并Ⅰ型呼吸衰竭患儿依据治疗方法分为对照组和试验组。对照组在常规治疗基础上进行常规氧疗；试验组在常规治疗基础上给予盐酸溴己新葡萄糖注射液（每次2~4 mg，qd，静脉滴注）联合高流量鼻导管氧疗；2组患儿均治疗7 d。比较2组患儿的临床疗效、呼吸循环指标和炎症指标，并进行安全性评价。
结果 共纳入94例患儿，其中对照组49例、试验组45例。治疗后，对照组和试验组临床总有效率分别为75.51%（37例/49例）和91.11%（41例/45例），试验组显著高于对照组（P<0.05）。治疗后，对照组和试验组的动脉血气氧分压（PaO2）水平分别为（75.43±7.71）和（80.35±8.63）mmHg，经皮血氧饱和度（SpO2）水平分别为（94.16±2.06）%和（95.31±2.33）%，PaO2/FiO2水平分别为327.08±34.36和342.40±33.53，呼吸频率（RR）水平分别为（30.16±3.39）和（28.33±3.03）time·min-1，乳酸水平分别为（2.66±0.43）和（2.38±0.34）mmol·L-1，白细胞介素-6（IL-6）水平分别为（14.45±3.37）和（12.64±3.31）pg·mL-1，白细胞（WBC）水平分别为（7.94±2.13）和（7.07±1.87）×109·L-1，中性粒细胞百分率（NEUT%）水平分别为（55.36±8.25）%和（51.58±7.43）%，降钙素原（PCT）水平分别为（0.17±0.04）和（0.15±0.04）ng·mL-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）。对照组的药物不良反应主要有面部皮肤损伤、鼻黏膜损伤和腹胀；试验组的药物不良反应主要有恶心、呕吐、面部皮肤损伤和鼻黏膜损伤。对照组和实验组的药物不良反应总发生率分别为14.29%（7例/49例）和11.11%（5例/45例），在统计学上差异无统计学意义（P>0.05）。
结论 小儿重症肺炎合并Ⅰ型呼吸衰竭应用盐酸溴己新葡萄糖注射液联合高流量鼻导管氧疗治疗方案的效果显著，能够明显改善临床症状、体征缓解时间及呼吸循环指标水平，降低炎性指标水平，促进肺炎吸收，提高治疗舒适度，缩短住院天数，并且安全性较好。
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夏彩凤（1979-），女，副主任医师，主要从事呼吸与危重症方面的临床工作和研究
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