Article(id=1292130322175521724, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.05.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750521600000, receivedDateStr=2025-06-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997475426, onlineDateStr=2026-08-06, pubDate=1773676800000, pubDateStr=2026-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997475426, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997475426, creator=13701087609, updateTime=1785997475426, updator=13701087609, issue=Issue{id=1292130254689165893, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1773676800000', pubDateStr='2026-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997459337, creator='13701087609', updateTime=1786014469153, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201599108141219, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201599108141220, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=625, endPage=629, ext={EN=ArticleExt(id=1292130323056325565, articleId=1292130322175521724, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of bifidobacterium triple viable capsule in patients with type Ⅲ prostatitis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the efficacy and safety of bifidobacterium triple viable capsule in patients with type Ⅲ prostatitis.
Methods Patients with type Ⅲ prostatitis in the hospital were retrospectively selected and divided into treatment group and control group. The two groups of patients both took sertraline tablets 0.05 g, once daily. Patients in control group were given oral administration of 0.2 mg of tamsulosin sustained release capsule once a day, while patients in treatment group received oral administration of 0.42 g of bifidobacterium triple viable capsule twice a day on the basis of control group. Both groups were treated for 4 weeks. The efficacy, clinical symptoms scores, urodynamic parameters and inflammatory factors were compared between the two groups, and the safety was evaluated.
Results A total of 200 patients were enrolled, including 97 cases in control group and 103 cases in treatment group. After 4 weeks of treatment, the total effective rate in treatment group was 88.35% (91 cases/103 cases), which was statistical significant higher than 79.38% (77cases/97 cases) in control group (P>0.05). After treatment, the scores of the pain domain of the national institutes of health chronic prostatitis symptom index (NIH-CPSI) in treatment group and control group were (4.37±1.42) and (5.04±1.56) point, respectively; the self-rating depression scale (SDS) scores were (38.20±5.38) and (40.63±5.54) point, respectively; the levels of interleukin-6 (IL-6) were (5.93±1.08) and (6.30±1.27) pg·mL-1, respectively; the levels of interleukin-10 (IL-10) were (6.21±1.37) and (6.62±1.49) pg·mL-1, respectively; and the levels of cyclooxygenase-2 (COX-2) were (9.46±2.66) and (10.26±2.02) ng·mL-1, respectively. There were statistical significant differences in the above indicators between treatment and control group (all P<0.05). The main adverse drug reactions in treatment group included dizziness, nausea and vomiting, and diarrhea, whereas dizziness and diarrhea occurred in control group. The overall incidence of adverse drug reactions was 4.85% (5 cases/103 cases) in treatment group and 2.06% (2 cases/97 cases) in control group, with no statistically significant difference between the two groups (P>0.05).
Conclusion Bifidobacterium triple viable capsule in the treatment of type Ⅲ prostatitis can improve the pain symptom and depression, and regulate the levels of inflammatory factors, and it has good safety.
, authors=Zhen-wei ZHAO
a, Yan-jie LIU
b, Jing-wen LI
b, Wei-dong ZHOU
a, authorsList=Zhen-wei ZHAO, Yan-jie LIU, Jing-wen LI, Wei-dong ZHOU, authorCompany=null, correspAuthors=Zhen-wei ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130325195420606, articleId=1292130322175521724, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=双歧杆菌三联活菌胶囊在Ⅲ型前列腺炎患者中的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察双歧杆菌三联活菌胶囊对Ⅲ型前列腺炎患者的临床疗效和安全性。
方法 将本院就诊的Ⅲ型前列腺炎患者按给药方式分为试验组和对照组。2组患者均口服舍曲林片0.05 g qd进行治疗；对照组在此基础上口服坦索罗辛缓释胶囊0.2 mg qd；试验组在对照组治疗基础上口服双歧杆菌三联活菌胶囊0.42 g bid，2组均治疗4周。比较2组的临床疗效、临床症状评分、尿流动力学参数和炎症因子水平，并进行安全性评价。
结果 最终入选200例患者，包括对照组97例、试验组103例。治疗后，试验组和对照组的总有效率分别为88.35%（91例/103例）和79.38%（77例/97例），在统计学上差异无统计学意义（P>0.05）。治疗后，试验组和对照组的美国国立卫生院慢性前列腺炎症状指数（NIH-CPSI）疼痛症状维度评分分别为（4.37±1.42）和（5.04±1.56）分，抑郁自评量表（SDS）评分分别为（38.20±5.38）和（40.63±5.54）分，IL-6水平分别为（5.93±1.08）和（6.30±1.27）pg·mL-1，IL-10水平分别为（6.21±1.37）和（6.62±1.49）pg·mL-1，COX-2水平分别为（9.46±2.66）和（10.26±2.02）ng·mL-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）。试验组主要的药物不良反应有头晕、恶心呕吐、腹泻，对照组有头晕、腹泻。试验组和对照组的总药物不良反应发生率分别为4.85%（5例/103例）和2.06%（2例/97例），在统计学上差异无统计学意义（P>0.05）。
结论 双歧杆菌三联活菌胶囊治疗Ⅲ型前列腺炎能够改善患者疼痛症状、抑郁情绪，调节患者炎症因子水平，安全性好。
, authors=赵振威
a, 刘艳洁
b, 李敬文
b, 周卫东
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赵振威（1988-），男，副主任医师，主要从事泌尿外科肿瘤、结石、前列腺增生及男科疾病方面的临床工作和研究
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