Article(id=1292130300486771426, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.08.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769011200000, receivedDateStr=2026-01-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997470255, onlineDateStr=2026-08-06, pubDate=1777305600000, pubDateStr=2026-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997470255, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997470255, creator=13701087609, updateTime=1785997470255, updator=13701087609, issue=Issue{id=1292130221843571059, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1777305600000', pubDateStr='2026-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997451505, creator='13701087609', updateTime=1786014411018, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201355276480844, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201355276480845, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1182, endPage=1188, ext={EN=ArticleExt(id=1292130305448633059, articleId=1292130300486771426, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on the treatment of polycystic ovary syndrome by traditional Chinese medicine regulating NLRP3 inflammasome, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Polycystic ovary syndrome (PCOS), a prevalent endocrine-metabolic disorder, is characterized by hyperandrogenemia, ovulatory dysfunction, and polycystic ovarian morphology. The nucleotide-binding leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3) inflammasome, an intracellular complex composed of active-NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC) and pro-cysteine aspartate specific proteinase 1 (Pro-Caspase-1), is activated by stimuli such as pathogen invasion, oxidative stress, and metabolic disorders, regulating the release of pro-inflammatory cytokines including interleukin-1β (IL-1β) and IL-18 to mediate inflammatory responses. PCOS is intricately linked to NLRP3 inflammasome activation: it triggers NLRP3 via mechanisms including ion imbalance, mitochondrial dysfunction, and metabolic product accumulation, leading to the release of pro-inflammatory factors that exacerbate ovarian inflammatory microenvironment, inhibit follicular development, and induce granulosa cell apoptosis. Concurrently, NLRP3 inflammasome activation exacerbates metabolic disorders and reproductive endocrine abnormalities by disrupting insulin signaling and promoting androgen synthesis, forming a "metabolism-inflammation-reproduction" vicious cycle. This paper systematically reviews the basic research progress of traditional Chinese medicine (TCM) in regulating NLRP3 inflammasome and deeply explores the synergistic mechanisms of TCM in anti-inflammatory and metabolic regulation within PCOS models, aiming to provide novel therapeutic strategies for PCOS.

, authors=Chong-chong PEI, Ying-ping LIU, Yan WANG, Cai-feng XU, Jun ZHENG, authorsList=Chong-chong PEI, Ying-ping LIU, Yan WANG, Cai-feng XU, Jun ZHENG, authorCompany=null, correspAuthors=Chong-chong PEI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130310578266854, articleId=1292130300486771426, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中医药调控NLRP3炎症小体治疗多囊卵巢综合征的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

多囊卵巢综合征（PCOS）是一种普遍的内分泌和代谢紊乱性疾病，以高雄激素血症、排卵功能障碍及卵巢多囊样改变为主要特征。核苷酸结合寡聚化结构域样受体（NLR）家族Pyrin结构域蛋白3（NLRP3）炎症小体是由active-NLRP3、凋亡相关斑点样蛋白（ASC）和半胱天冬酶-1前体（Pro-Caspase-1）组成的胞内复合体，可在病原体入侵、氧化应激、代谢紊乱等刺激下激活，调控白细胞介素-1β（IL-1β）和IL-18释放，进而干扰胰岛素信号传导、促进雄激素合成等机制，加重代谢紊乱与生殖内分泌异常，形成“代谢-炎症-生殖”的恶性循环。中药在PCOS的治疗应用已久，特别是通过调控NLRP3炎症小体对PCOS有良好的调节作用而被广泛研究。因此，本文通过对中医药调控NLRP3炎症小体的基础研究进展进行系统总结，对中医药在PCOS模型中抗炎-代谢调节的协同机制展开深度综述，以期为PCOS的治疗提供了新的策略方向。

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裴重重（1990-），女，副主任护师，研究方向为中医药对多囊卵巢综合征作用机制的研究

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