Article(id=1292126590830408604, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.03.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747670400000, receivedDateStr=2025-05-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996585804, onlineDateStr=2026-08-06, pubDate=1771257600000, pubDateStr=2026-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996585804, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996585804, creator=13701087609, updateTime=1785996585804, updator=13701087609, issue=Issue{id=1292126460546929080, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1771257600000', pubDateStr='2026-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996554742, creator='13701087609', updateTime=1786014541627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201903060963536, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201903060963537, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=399, endPage=404, ext={EN=ArticleExt(id=1292126592432632733, articleId=1292126590830408604, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical study on the genetic polymorphism of aspirin in patients with ischemic stroke, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the gene polymorphism of aspirin drug-related genes platelet membrane glycoprotein Ⅲa phospholipase A2 (GPⅢa PLA2), platelet endothelial aggregation receptor 1 (PEAR1), glutathione S-transferase P1 (GSTP1) and prostaglandin endoperoxide synthase 1 (PTGS1) in patients with ischemic stroke in Beijing.
Methods Patients with ischemic stroke in the neurology department of our hospital were included as research subjects, and the polymorphism of drug-related gene loci was detected by fluorescence in situ hybridization sequencing.
Results The overall mutation rate of aspirin related genes was 75.42% (356 cases/472 cases). GPⅢa PLA 2 typing included 458 cases TT type, 11 cases TC type and 3 cases CC type, C allele frequency was 1.80% (17 cases/944 cases); PEAR1 typing included 187 cases GG type, 224 cases GA type and 61 cases AA type, A allele frequency was 36.65% (346 cases/944 cases); GSTP1 typing included 295 cases AA type, 160 cases GA type and 17 cases GG type, G allele frequency was 20.55% (194 cases/944 cases); typing of PTGS1 included 50 cases AA type, and the frequency of G allele was 0. GPⅢa PLA2 TT+PEAR1 GA+GSTP1 AA was the most common combination, accounting for 138 cases (29.24%). There was no statistically significant difference in gene polymorphisms of GPⅢa PLA2, PEAR1, GSTP1 between different genders and ages (all P>0.05). The genotype and allele distributions of GPⅢa PLA2, PEAR1, GSTP1 and PTGS1 in patients with ischemic stroke in Beijing were not statistically significantly different from those in Zaozhuang, Nanjing and Shanghai (all P>0.05), while the genotype and allele distributions of GPⅢa PLA2, PEAR1 and GSTP1 were statistically significantly different from those in Guangdong (all P<0.05).
Conclusion PEAR1 and GSTP1 are the main mutations in aspirin drug-related genes in patients with ischemic stroke in Beijing. The mutation ratio of GPⅢa PLA2 and PTGS1 gene is low, and the gene polymorphism in Beijing is different from that in other regions.
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目的 分析阿司匹林药物相关基因血小板膜糖蛋白Ⅲa磷脂酶A2（GPⅢa PLA2）、血小板内皮聚集受体1（PEAR1）、谷胱甘肽硫转移酶P1（GSTP1）和前列腺素内过氧化物合酶1（PTGS1）在北京地区缺血性脑卒中患者中的基因多态性。
方法 将本院神经内科缺血性脑卒中患者纳入为研究对象，用荧光原位杂交测序法检测相关基因多态性。
结果 本研究共纳入472例患者。阿司匹林用药相关基因总体突变率为75.42%（356例/472例）。GPⅢa PLA2分型显示，TT型458例，TC型11例，CC型3例，突变型C等位基因频率为1．80％（17例/944例）；PEAR1分型显示，GG型187例，GA型224例，AA型61例，突变型A等位基因频率为36.65％（346例/944例）；GSTP1分型显示，AA型295例，GA型160例，GG型17例，突变型G等位基因频率为20.55%（194例/944例）；PTGS1分型显示，AA型50例，突变型G等位基因频率为0。GPⅢa PLA2 TT+PEAR1 GA+GSTP1 AA组合最多见，为138例（29.24%）。GPⅢa PLA2、PEAR1、GSTP1基因多态性在不同性别和年龄间比较，在统计学上差异均无统计学意义（均P>0.05）。北京地区缺血性脑卒中患者GPⅢa PLA2、PEAR1、GSTP1、PTGS1基因型和等位基因分布与枣庄、南京、上海地区比较，在统计学上差异均无统计学意义（均P>0.05），GPⅢa PLA2和PEAR1的基因型和等位基因分布及GSTP1的等位基因分布与广东地区比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 PEAR1基因和GSTP1基因是北京地区缺血性脑卒中患者阿司匹林药物相关基因中的主要突变基因，GPⅢa PLA2基因和PTGS1基因突变比例低，北京地区患者基因多态性和其他地区存在一定差异。
, authors=贾双双, 朴颖实, authorsList=贾双双, 朴颖实, authorCompany=null, correspAuthors=朴颖实, authorNote=
贾双双（1988-），女，主管技师，主要从事病理检测工作及药物基因组学相关研究
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