Article(id=1292126498354389836, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.03.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996563757, onlineDateStr=2026-08-06, pubDate=1771257600000, pubDateStr=2026-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996563757, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996563757, creator=13701087609, updateTime=1785996563757, updator=13701087609, issue=Issue{id=1292126460546929080, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1771257600000', pubDateStr='2026-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996554742, creator='13701087609', updateTime=1786014541627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201903060963536, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201903060963537, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=419, endPage=426, ext={EN=ArticleExt(id=1292126498543133517, articleId=1292126498354389836, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Current research on the mechanisms by which chinese medicinal monomer regulate osteogenesis-angiogenesis coupling in the treatment of osteoporosis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Osteoporosis (OP) is a severe skeletal system disease that endangers human physical and mental health, characterized primarily by decreased bone mineral density, impaired bone tissue quality, disrupted bone microstructure and reduced bone mechanical strength. The pathogenesis of OP involves multiple aspects, including impaired communication between osteoblasts and osteoclasts, dysregulated bone remodeling homeostasis, as well as angiogenesis disorders, chronic inflammatory responses and oxidative stress damage. Notably, the correlation between angiogenesis and osteogenesis exists throughout bone formation, the development and progression of OP, and fracture healing, serving as a key link in the regulation of bone metabolism. In recent years, traditional Chinese medicine (TCM) has demonstrated remarkable advantages and definite curative effects in the prevention and treatment of OP. Commonly used Chinese medicinal monomer in clinical practice can promote the proliferation and differentiation of osteoblasts through multiple pathways and targets, enhance the angiogenic capacity of osteogenic tissue, improve blood supply to bone tissue, and thereby increase bone mineral density, which is of great significance for the prevention and treatment of OP. This paper systematically reviews the recent research progress on Chinese medicinal monomer in the treatment of OP, aiming to explore new diagnostic and therapeutic ideas and practical approaches for the prevention and treatment of this disease with TCM.

, authors=Hu LU¹, Xin CHEN², Yi-xin CHEN³, Wen-bo AN², Wei QI², Nuo CHEN¹, Hui LI¹, Jian-jun LIU², authorsList=Hu LU, Xin CHEN, Yi-xin CHEN, Wen-bo AN, Wei QI, Nuo CHEN, Hui LI, Jian-jun LIU, authorCompany=null, correspAuthors=Jian-jun LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126498765431630, articleId=1292126498354389836, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药单体调控成骨-血管耦合机制治疗骨质疏松症的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

骨质疏松症（OP）是一种严重的危害人类身心健康的骨骼系统疾病，主要的病理特点是骨密度降低、骨组织质量下降、骨微结构破损、骨力学强度减弱。导致OP的发病机理涉及成骨细胞、破骨细胞间通讯功能障碍、骨重塑稳态失调；血管生成障碍、慢性炎症反应、氧化应激损伤等多方面。值得注意的是，在骨组织生成、OP发生发展以及骨折愈合的过程中，始终存在着血管生成与骨形成之间的关联，是调控骨代谢的关键环节。近年来，中医药（TCM）在防治OP方面表现出显著的优势及确切疗效，临床中应用较多的单体中药通过多途径、多靶点促进成骨细胞增殖分化，并且能够提高成骨血管生成的能力，改善骨组织血供，进而使得骨密度得以提升，对预防和治疗OP均有十分重要的意义。本文系统综述近年来中药单体治疗OP的研究进展，旨在为TCM防治该病探索新的诊疗思路与实践路径。

, authors=路虎¹, 陈欣², 陈一新³, 安文博², 齐伟², 陈诺¹, 李慧¹, 刘建军², authorsList=路虎, 陈欣, 陈一新, 安文博, 齐伟, 陈诺, 李慧, 刘建军, authorCompany=null, correspAuthors=刘建军, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=TJiSnYZAjvR81itkK++eJw==, magXml=XOnc/XuxMZnroqlG1cYuDQ==, pdfUrl=null, pdf=JtHyakTYTQlEgcZPex3COA==, pdfFileSize=1717043, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=a4Pp47qyYEi6NcVRDg5YYA==, mapNumber=null, fund=null)}, authors=[Author(id=1292126499201639257, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126498354389836, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126499272942427, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126498354389836, authorId=1292126499201639257, language=EN, stringName=Hu LU, firstName=Hu, middleName=null, lastName=LU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.School of Clinical Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126499331662684, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126498354389836, authorId=1292126499201639257, language=CN, stringName=路虎, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.甘肃中医药大学 中医临床学院，甘肃 兰州 730000, bio={"content":"

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路虎（1999-），男，硕士研究生，主要从事中医药防治骨与关节疾病方面的研究

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