Article(id=1292126471934468721, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.03.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1765987200000, receivedDateStr=2025-12-18, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996557457, onlineDateStr=2026-08-06, pubDate=1771257600000, pubDateStr=2026-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996557457, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996557457, creator=13701087609, updateTime=1785996557457, updator=13701087609, issue=Issue{id=1292126460546929080, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1771257600000', pubDateStr='2026-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996554742, creator='13701087609', updateTime=1786014541627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201903060963536, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201903060963537, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=381, endPage=385, ext={EN=ArticleExt(id=1292126473679299186, articleId=1292126471934468721, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical characteristics analysis of 21 elderly patients with statin-associated myopathy, columnId=1291704944038536012, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Rational Use of Drugs, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the etiological factors and clinical characteristics of statin-associated myopathy in elderly patients.
Methods A retrospective analysis was performed on elderly patients with statina-ssociated myopathy who were treated in the internal medicine department of our hospital from January 2017 to June 2024. Data including etiology, clinical manifestations, treatment process and prognosis were collected and analyzed.
Results A total of 21 elderly patients with statina-ssociated myopathy were enrolled, including 13 males and 8 females, with an average age of (77.33±9.61) years. Among them, 5 patients were diagnosed with rhabdomyolysis. According to the type of statin taken, patients were divided into 5 groups: atorvastatin group, rosuvastatin group, simvastatin group, pitavastatin group and Xuezhikang group. All patients received monotherapy without overlapping or combined use of different statins. The duration of statin therapy at onset ranged from 2 weeks to 10 years. Precipitating factors included infection, concomitant medications, stress and exercise. Among them, 12 cases were related to infection (9 pneumonia, 2 urinary tract infections, 1 intestinal infection), and 2 cases were associated with concomitant medications (quetiapine and cyclosporine A, respectively). Most patients had multiple comorbidities: hypertension in 90.48% (19 cases/21 cases), type 2 diabetes mellitus in 66.67% (14 cases/21 cases), coronary heart disease in 47.62% (10 cases/21 cases), and chronic kidney disease in 23.81% (5 cases/21 cases). Patients were on multiple concomitant medications, with a mean of 6 drugs used. Acute kidney injury occurred in 4 patients with myopathy and in 5 patients with rhabdomyolysis. After comprehensive treatment including statin discontinuation, fluid replacement, urine alkalinization and blood purification, all patients improved and no deaths occurred. Serum creatinine in patients with acute kidney injury returned to normal or baseline levels before onset.
Conclusion Elderly patients with acute infection, concomitant medications and multiple comorbidities should be closely monitored for the risk of statinassociated myopathy or rhabdomyolysis. Acute kidney injury is common in such elderly patients. Early discontinuation of statins and comprehensive treatment including symptomatic fluid infusion and blood purification can significantly improve patient prognosis.
, authors=Yan FAN, Jing-jing HAN, Jia-li DU, Mei-lin LIU, Zhi-fang FU, authorsList=Yan FAN, Jing-jing HAN, Jia-li DU, Mei-lin LIU, Zhi-fang FU, authorCompany=null, correspAuthors=Zhi-fang FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126474119701107, articleId=1292126471934468721, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=老年患者他汀类药物相关肌病21例分析, columnId=1291704944210502478, journalTitle=中国临床药理学杂志, columnName=合理用药, runingTitle=null, highlight=null, articleAbstract=
目的 探讨他汀类药物相关肌病老年患者的起病因素和临床特点。
方法 回顾分析2017年1月至2024年6月本院内科收治的他汀相关肌病老年患者的病因、临床表现、治疗经过及预后转归。
结果 共收治他汀类药物相关肌病老年患者21例，男性13例、女性8例，年龄（77.33±9.61）岁，其中5例患者诊断为横纹肌溶解症。将纳入患者按服用不同他汀类药物分成5组：阿托伐他汀组、瑞舒伐他汀组、辛伐他汀组、匹伐他汀组及血脂康组，各组患者均为单一用药，无交叉重叠用药情况。起病时他汀类药物使用时间2周～10年。诱因包括感染、合并药物、应激、运动等，其中感染12例（肺炎9例，泌尿系感染2例，肠道感染1例）、合并用药2例（分别为喹硫平、环孢素A）。患者合并多种基础疾病，其中90.48%（19例/21例）合并高血压、66.67%（14例/21例）合并2型糖尿病、47.62%（10例/21例）合并冠心病、23.81%合并（5例/21例）慢性肾病。患者联用多种药物，平均使用6种药物。有4例肌病患者出现急性肾损伤，5例横纹肌溶解症患者合并急性肾损伤。经停用他汀类药物、补液、碱化尿液、血液净化等综合治疗，所有患者病情好转，无患者死亡。发生急性肾损伤的患者血肌酸酐均恢复正常或发病前基础水平。
结论 对于急性感染、合并用药、基础疾病多的老年患者需警惕他汀类药物相关肌病或横纹肌溶解症风险，老年患者易合并急性肾损伤。及时停用他汀类药物，经对症补液、血液净化等综合治疗可明显改善患者预后。
, authors=范琰, 韩晶晶, 杜佳丽, 刘梅林, 付志方, authorsList=范琰, 韩晶晶, 杜佳丽, 刘梅林, 付志方, authorCompany=null, correspAuthors=付志方, authorNote=
范琰（1974-），女，副主任医师，主要从事老年心血管疾病相关的工作和研究
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