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Article(id=1292126465630425561, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.03.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1766678400000, receivedDateStr=2025-12-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996555955, onlineDateStr=2026-08-06, pubDate=1771257600000, pubDateStr=2026-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996555955, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996555955, creator=13701087609, updateTime=1785996555955, updator=13701087609, issue=Issue{id=1292126460546929080, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1771257600000', pubDateStr='2026-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996554742, creator='13701087609', updateTime=1786014541627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201903060963536, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201903060963537, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=344, endPage=349, ext={EN=ArticleExt(id=1292126465865306586, articleId=1292126465630425561, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of factors influencing dose-corrected concentrations of vortioxetine in depressed patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To analyze the steady state plasma concentrations and dose-corrected concentration(C/D) influencing factors of vortioxetine tablets in patients with depression, and to provide guidance in the practice of rational clinical use of vortioxetine tablets in patients with depression.

Methods

Patients with depression who took vortioxetine and underwent therapeutic drug monitoring of blood concentrations in our hospital from March 2022 to November 2024 were selected as the study subjects, and their blood concentrations were monitored. Laboratory indicators, demographic information and the effect of coadministration on dose-corrected concentrations of vortioxetine tablets were statistically analyzed by SPSS 26.0.

Results

A total of 90 patients were enrolled, and 107 sessions of blood concentration monitoring were performed. In depressed patients, the steady state plasma concentration was (28.05±20.28) ng·mL-1, the administered daily dose was (14.86 ± 5.21) mg·d-1, and the dose-corrected concentration was (1.96±1.24) ng·mL-1·mg-1·d. 69.16% (74 cases/107 cases) of C/D exceeded the upper limit of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie(AGNP) guideline reference range. The body weight, alanine aminotransferase(ALT), and urea, as well as the combination of paliperidone, aripiprazole, or clozapine all had a significant effect on the dose-corrected concentration of vortioxetine (all P<0.05). Multiple linear regression analysis revealed that body weight and the combination of aripiprazole had a significant effect on vortioxetine C/D (F=8.517, R2=0.148, P<0.001).

Conclusion

When vortioxetine is used clinically, the dosage should be adjusted according to the patient’s body weight. When it is used in conjunction with aripiprazole, regular monitoring of the plasma concentration should be carried out.

, authors=Li-jing DAI1, 4, Gui-lan WU2, Ye YANG1, Yu-qing CHEN1, Yao-qi WEN1, Wei ZOU2, Yong-yu DIND2, Bei-chen FAN1, De-wei SHANG1, 3, Yu-guan WEN1, 3, authorsList=Li-jing DAI, Gui-lan WU, Ye YANG, Yu-qing CHEN, Yao-qi WEN, Wei ZOU, Yong-yu DIND, Bei-chen FAN, De-wei SHANG, Yu-guan WEN, authorCompany=null, correspAuthors=Yu-guan WEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126466083410395, articleId=1292126465630425561, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=伏硫西汀在抑郁症患者中剂量校正浓度影响因素分析, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

分析伏硫西汀片在抑郁症患者中的稳态血药浓度及剂量校正浓度（C/D）影响因素，为伏硫西汀片在抑郁症患者的临床合理用药实践中提供指导。

方法

选取2022年3月至2024年11月于本院服用伏硫西汀片并进行血药浓度监测的抑郁症患者作为研究对象，监测血药浓度。用SPSS 26.0进行统计分析实验室指标、人口统计学资料及合并用药对伏硫西汀片剂量校正浓度的影响。

结果

共纳入90例患者，共监测107例次血药浓度。抑郁症患者的稳态血药浓度为（28.05±20.28）ng·mL-1，给药日剂量为（14.86±5.21）mg·d-1，剂量校正浓度为（1.96±1.24）ng·mL-1·mg-1·d，有69.16%（74例/107例）C/D超出神经精神药理学与药物精神病学协会（AGNP）指南参考范围的上限；体重、谷丙转氨酶（ALT）、尿素以及合并帕利哌酮、阿立哌唑或氯氮平对伏硫西汀剂量校正浓度均有显著影响（均P<0.05）。通过多元线性回归分析发现，体重与合并阿立哌唑对伏硫西汀C/D具有显著影响（F=8.52，R2=0.15，P<0.001）。

结论

临床上使用伏硫西汀时，需根据患者体重进行给药剂量的调整，与阿立哌唑合并用药时，应进行定期的血药浓度监测。

, authors=戴丽静1, 4, 巫贵兰2, 杨烨1, 陈玉清1, 温耀祺1, 邹炜2, 丁勇宇2, 范北辰1, 尚德为1, 3, 温预关1, 3, authorsList=戴丽静, 巫贵兰, 杨烨, 陈玉清, 温耀祺, 邹炜, 丁勇宇, 范北辰, 尚德为, 温预关, authorCompany=null, correspAuthors=温预关, authorNote=

戴丽静（1998-），女，硕士研究生，主要从事临床药学与药物Ⅰ期临床试验方面的研究

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温预关，主任药师，硕士生导师 MP: 18922165263 E-mail:
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戴丽静（1998-），女，硕士研究生，主要从事临床药学与药物Ⅰ期临床试验方面的研究

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戴丽静（1998-），女，硕士研究生，主要从事临床药学与药物Ⅰ期临床试验方面的研究

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伏硫西汀在抑郁症患者中剂量校正浓度影响因素分析
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戴丽静 1, 4 , 巫贵兰 2 , 杨烨 1 , 陈玉清 1 , 温耀祺 1 , 邹炜 2 , 丁勇宇 2 , 范北辰 1 , 尚德为 1, 3 , 温预关 1, 3
中国临床药理学杂志 | 临床与基础桥接研究 2026,42(3): 344-349
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中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (3) : 344 -349
伏硫西汀在抑郁症患者中剂量校正浓度影响因素分析
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戴丽静1, 4, 巫贵兰2, 杨烨1, 陈玉清1, 温耀祺1, 邹炜2, 丁勇宇2, 范北辰1, 尚德为1, 3, 温预关1, 3
作者信息
  • 1.广州医科大学 附属脑科医院，广东 广州 510370
  • 2.惠州市第二人民医院，广东 惠州 516008
  • 3.广东省神经科学疾病研究重点实验室、神经致病基因和离子通道教育部重点实验室，广东 广州 510370
  • 4.东莞市第七人民医院，广东 东莞 523230
通讯作者:
温预关，主任药师，硕士生导师 MP: 18922165263 E-mail:
作者简介:

戴丽静（1998-），女，硕士研究生，主要从事临床药学与药物Ⅰ期临床试验方面的研究

Analysis of factors influencing dose-corrected concentrations of vortioxetine in depressed patients
Li-jing DAI1, 4, Gui-lan WU2, Ye YANG1, Yu-qing CHEN1, Yao-qi WEN1, Wei ZOU2, Yong-yu DIND2, Bei-chen FAN1, De-wei SHANG1, 3, Yu-guan WEN1, 3
Affiliations
  • 1.The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, Guangdong Province, China
  • 2.Huizhou Second People’s Hospital, Huizhou 516008, Guangdong Province, China
  • 3.Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou 510370, Guangdong Province, China
  • 4.Dongguan Seventh People’s Hospital, Dongguan 523230, Guangdong Province China
出版时间: 2026-02-17 doi: 10.13699/j.cnki.1001-6821.2026.03.008
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摘要
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目的

分析伏硫西汀片在抑郁症患者中的稳态血药浓度及剂量校正浓度（C/D）影响因素，为伏硫西汀片在抑郁症患者的临床合理用药实践中提供指导。

方法

选取2022年3月至2024年11月于本院服用伏硫西汀片并进行血药浓度监测的抑郁症患者作为研究对象，监测血药浓度。用SPSS 26.0进行统计分析实验室指标、人口统计学资料及合并用药对伏硫西汀片剂量校正浓度的影响。

结果

共纳入90例患者，共监测107例次血药浓度。抑郁症患者的稳态血药浓度为（28.05±20.28）ng·mL-1，给药日剂量为（14.86±5.21）mg·d-1，剂量校正浓度为（1.96±1.24）ng·mL-1·mg-1·d，有69.16%（74例/107例）C/D超出神经精神药理学与药物精神病学协会（AGNP）指南参考范围的上限；体重、谷丙转氨酶（ALT）、尿素以及合并帕利哌酮、阿立哌唑或氯氮平对伏硫西汀剂量校正浓度均有显著影响（均P<0.05）。通过多元线性回归分析发现，体重与合并阿立哌唑对伏硫西汀C/D具有显著影响（F=8.52，R2=0.15，P<0.001）。

结论

临床上使用伏硫西汀时，需根据患者体重进行给药剂量的调整，与阿立哌唑合并用药时，应进行定期的血药浓度监测。

伏硫西汀片  /  抑郁症  /  剂量校正浓度  /  治疗药物监测
Objective

To analyze the steady state plasma concentrations and dose-corrected concentration(C/D) influencing factors of vortioxetine tablets in patients with depression, and to provide guidance in the practice of rational clinical use of vortioxetine tablets in patients with depression.

Methods

Patients with depression who took vortioxetine and underwent therapeutic drug monitoring of blood concentrations in our hospital from March 2022 to November 2024 were selected as the study subjects, and their blood concentrations were monitored. Laboratory indicators, demographic information and the effect of coadministration on dose-corrected concentrations of vortioxetine tablets were statistically analyzed by SPSS 26.0.

Results

A total of 90 patients were enrolled, and 107 sessions of blood concentration monitoring were performed. In depressed patients, the steady state plasma concentration was (28.05±20.28) ng·mL-1, the administered daily dose was (14.86 ± 5.21) mg·d-1, and the dose-corrected concentration was (1.96±1.24) ng·mL-1·mg-1·d. 69.16% (74 cases/107 cases) of C/D exceeded the upper limit of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie(AGNP) guideline reference range. The body weight, alanine aminotransferase(ALT), and urea, as well as the combination of paliperidone, aripiprazole, or clozapine all had a significant effect on the dose-corrected concentration of vortioxetine (all P<0.05). Multiple linear regression analysis revealed that body weight and the combination of aripiprazole had a significant effect on vortioxetine C/D (F=8.517, R2=0.148, P<0.001).

Conclusion

When vortioxetine is used clinically, the dosage should be adjusted according to the patient’s body weight. When it is used in conjunction with aripiprazole, regular monitoring of the plasma concentration should be carried out.

vortioxetine tablets  /  depression  /  dose-corrected concentration  /  therapeutic drug monitoring
戴丽静, 巫贵兰, 杨烨, 陈玉清, 温耀祺, 邹炜, 丁勇宇, 范北辰, 尚德为, 温预关. 伏硫西汀在抑郁症患者中剂量校正浓度影响因素分析. 中国临床药理学杂志, 2026 , 42 (3) : 344 -349 . DOI: 10.13699/j.cnki.1001-6821.2026.03.008
Li-jing DAI, Gui-lan WU, Ye YANG, Yu-qing CHEN, Yao-qi WEN, Wei ZOU, Yong-yu DIND, Bei-chen FAN, De-wei SHANG, Yu-guan WEN. Analysis of factors influencing dose-corrected concentrations of vortioxetine in depressed patients[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (3) : 344 -349 . DOI: 10.13699/j.cnki.1001-6821.2026.03.008
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  • 中华国际医学交流基金会临床药学发展专项基金资助项目(Z-2014-08-2309-5)
  • 广东省医院药学研究基金（澳美基金）资助项目(2024A34)
  • 广东省临床用药研究基金资助项目(2023JZ14; 2022JZ34)
  • 2024年惠州市医疗卫生领域科技计划基金资助项目(2024CZ010140)
  • 广州市医学重点学科基金资助项目(2025-2027年)
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doi: 10.13699/j.cnki.1001-6821.2026.03.008
  • 接收时间：2025-12-26
  • 首发时间：2026-08-06
  • 出版时间：2026-02-17
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  • 收稿日期：2025-12-26
基金
中华国际医学交流基金会临床药学发展专项基金资助项目(Z-2014-08-2309-5)
广东省医院药学研究基金（澳美基金）资助项目(2024A34)
广东省临床用药研究基金资助项目(2023JZ14; 2022JZ34)
2024年惠州市医疗卫生领域科技计划基金资助项目(2024CZ010140)
广州市医学重点学科基金资助项目(2025-2027年)
作者信息
    1.广州医科大学 附属脑科医院，广东 广州 510370
    2.惠州市第二人民医院，广东 惠州 516008
    3.广东省神经科学疾病研究重点实验室、神经致病基因和离子通道教育部重点实验室，广东 广州 510370
    4.东莞市第七人民医院，广东 东莞 523230

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温预关，主任药师，硕士生导师 MP: 18922165263 E-mail:
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