Article(id=1292126453278208695, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.01.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747670400000, receivedDateStr=2025-05-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996553010, onlineDateStr=2026-08-06, pubDate=1768579200000, pubDateStr=2026-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996553010, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996553010, creator=13701087609, updateTime=1785996553010, updator=13701087609, issue=Issue{id=1292126377440989952, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='1', pageStart='1', pageEnd='147', issueExtLink='null', onlineDate='null', pubDate='1768579200000', pubDateStr='2026-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996534929, creator='13701087609', updateTime=1786014708731, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202603945947673, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202603950141978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126377440989952, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=112, endPage=118, ext={EN=ArticleExt(id=1292126453911548600, articleId=1292126453278208695, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Efficacy and safety of dapagliflozin combined with metformin in the treatment of type 2 diabetes mellitus, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To systematically evaluate the efficacy and safety of dapagliflozin (ForxigaTM) combined with metformin (MET) in the treatment of type 2 diabetes mellitus (T2DM).
Methods Several databases such as China National Knowledge Infrastructure (CNKI) and PubMed were searched by computer. To collect a randomized controlled trial of dapagliflozin combined with metformin in the treatment of type 2 diabetes. Quality evaluation, data extraction and data analysis of the literature were condueted. Glycosylated hemoglobin level, fasting blood glucose, 2 h postprandial blood glucose, fasting insulin, islet β - cell function, insulin resistance index, the incidence of adverse events, hypoglycemia and urinary tract infection were analyzed by RevMan5.4 software.
Results A total of 9 eligible randomized controlled trials (RCTs) involving 867 type 2 diabetes mellitus patients were included in the final analysis. As it turns out, the efficacy of dapagliflozin combined with MET group was significantly better than that of metformin alone (P<0.05), and the safety of the combined group had no statistically significant differince (P>0.05).
Conclusion Compared with metformin monotherapy, the combination therapy of dapagliflozin and metformin yields significantly improved clinical outcomes in T2DM patients without increasing the incidence of adverse drug reactions. These findings provide robust scientific evidence for the rational clinical application of this therapeutic regimen.
, authors=Bing-rong CHEN
1, Zhi-qin HU
2, Si-chao ZHENG
2, authorsList=Bing-rong CHEN, Zhi-qin HU, Si-chao ZHENG, authorCompany=null, correspAuthors=Si-chao ZHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126454217732793, articleId=1292126453278208695, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=达格列净联合二甲双胍治疗2型糖尿病的疗效与安全性分析, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 探究达格列净（ForxigaTM）联合二甲双胍（MET）治疗2型糖尿病（T2DM）的疗效和安全性。
方法 检索中国知网、PubMed等多个数据库，收集达格列净联合二甲双胍治疗2型糖尿病的随机对照试验。对文献进行质量评价，资料提取以及数据分析，结局指标为糖化血红蛋白水平、空腹血糖、餐后2 h血糖、空腹胰岛素、胰岛β细胞功能、胰岛素抵抗指数、不良事件发生率、低血糖发生率和泌尿系统感染发生率，用RevMan5.4软件开展Meta分析。
结果 最终纳入9项符合标准的随机对照研究（RCT），累计867例2型糖尿病患者。结果显示，ForxigaTM联合MET组在治疗效果方面显著优于单用二甲双胍对照组（P<0.05）；联合组在安全性方面与对照组比较，在统计学上差异无统计学意义（P>0.05）。
结论 相较于单用二甲双胍，达格列净联合二甲双胍治疗T2DM的疗效更为突出，且未增加药物不良反应风险，可以为临床治疗方案的合理选择提供循证医学依据。
, authors=陈冰蓉
1, 胡志琴
2, 郑思超
2, authorsList=陈冰蓉, 胡志琴, 郑思超, authorCompany=null, correspAuthors=郑思超, authorNote=
陈冰蓉（2001-），女，药师，主要从事临床药理学相关研究
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