Article(id=1292126434970063074, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996548644, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996548644, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996548644, creator=13701087609, updateTime=1785996548644, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=164, endPage=170, ext={EN=ArticleExt(id=1292126435183972579, articleId=1292126434970063074, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A clinical study on the efficacy and safety of alirocumab combined with ticagrelor for patients with moderate coronary artery stenosis accompanied by angina pectoris, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of alirocumab injection combined with ticagrelor tablets in treating patients with moderate coronary artery stenosis accompanied by angina pectoris.
Methods Patients exhibiting moderate coronary artery stenosis and angina pectoris were categorized into two groups according to their treatment methods: treatment group and control group. Both groups received basic treatment. The control group received additional ticagrelor tablets, starting with a dose of 180 mg, followed by 90 mg twice daily. The treatment group added alirocumab injection at an initial dose of 75 mg, subcutaneously injected every two weeks, with dose adjustments made from weeks 4-8 based on lipid levels. Both groups continued treatment for 12 weeks. The clinical efficacy, angina attack frequency, use of nitroglycerin tablets, echocardiographic parameters, lipid levels, coagulation and myocardial injury markers, Seattle Angina Questionnaire scores, 6-minute walk distances and safety evaluation were compared between the two groups. Safety was also evaluated.
Results A total of 92 patients were enrolled in this study, with 45 and 47 patients assigned to the control group and the treatment group, respectively. After treatment, the total effective rates were 75.56% (34 cases/45 cases) for the control group and 91.49% (43 cases/47 cases) for the treatment group. The corrected QTc intervals were (387.38±18.62) and (379.29±17.54) ms, respectively; QRS durations were (98.38±7.27) and (97.45±6.74) ms; cardiac outputs were (4.82±0.63) and (5.17±0.68) L·min-1; cardiac indexes were (3.17±0.42) and (3.39±0.48) L·(min·m2)-1; total cholesterol levels were (4.11±0.82) and (3.58±0.71) mmol·L-1; triglyceride levels were (3.42±0.63) and (3.05±0.57) mmol·L-1; low-density lipoprotein cholesterol levels were (3.42±0.54) and (2.95±0.40) mmol·L-1; free fatty acid levels were (0.54±0.07) and (0.48±0.08) mmol·L-1. The differences in the above indicators between the treatment group and the control group were all statistically significant (all P<0.05). The incidence rates of adverse reactions in control group and treatment group were 11.11% (5 cases/45 cases) and 14.89% (7 cases/47 cases), with no statistically significant difference (P>0.05).
Conclusion Both alirocumab injection combined with ticagrelor tablets and ticagrelor tablets alone can treat moderate coronary artery stenosis associated with angina pectoris, however, the combination therapy more significantly improves efficacy, reduces the frequency of angina attacks and blood lipid levels, enhances overall cardiac function and quality of life, with good safety.
, authors=Jia SONG, Yu-mei YAO, Hong-wei HOU, authorsList=Jia SONG, Yu-mei YAO, Hong-wei HOU, authorCompany=null, correspAuthors=Jia SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126435423047908, articleId=1292126434970063074, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=阿利西尤单抗联合替格瑞洛治疗中度冠状动脉狭窄伴心绞痛患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察阿利西尤单抗注射液联合替格瑞洛片治疗中度冠状动脉狭窄伴心绞痛患者的临床疗效及安全性。
方法 将中度冠状动脉狭窄伴心绞痛患者按照治疗方法分为试验组和对照组。对照组在常规治疗方案基础上，口服替格瑞洛片，首剂量为180 mg，之后改为每次90 mg，bid。试验组于对照组基础上加用阿利西尤单抗注射液，起始剂量为75 mg，皮下注射，每2周1次，使用4~8 w后根据患者血脂水平调整剂量。2组患者均持续治疗12 w。比较两组临床疗效、心绞痛发作情况与硝酸甘油片用量、心脏超声参数、血脂水平、凝血与心肌损伤指标、西雅图心绞痛量表评分、6 min步行距离、安全性评价。
结果 共纳入92例患者，对照组和试验组分别纳入45和47例。治疗后，对照组和试验组的总有效率分别为75.56%（34例/45例）和91.49%（43例/47例）；校正后QTc间期分别为（387.38±18.62）和（379.29±17.54）ms；QRS时限分别为（98.38±7.27）和（97.45±6.74）ms；心排血量分别为（4.82±0.63）和（5.17±0.68）L·min-1；心脏指数分别为（3.17±0.42）和（3.39±0.48）L·（min·m2）-1；总胆固醇分别为（4.11±0.82）和（3.58±0.71）mmol·L-1；甘油三酯分别为（3.42±0.63）和（3.05±0.57）mmol·L-1；低密度脂蛋白胆固醇分别为（3.42±0.54）和（2.95±0.40）mmol·L-1；游离脂肪酸分别为（0.54±0.07）和（0.48±0.08）mmol·L-1。试验组上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。对照组和试验组不良反应发生率分别为11.11%（5例/45例）和14.89%（7例/47例），在统计学上差异无统计学意义（P>0.05）。
结论 阿利西尤单抗注射液联合替格瑞洛片与单用替格瑞洛片均能治疗中度冠状动脉狭窄伴心绞痛，但联合用药提升疗效、降低心绞痛的发作频率及血脂水平、提升心脏的整体功能及生活质量的效果更为显著，且安全性良好。
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宋佳（1981-），女，主治医师，主要从事心血管疾病内科治疗以及冠脉介入方面的临床工作和研究
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宋佳（1981-），女，主治医师，主要从事心血管疾病内科治疗以及冠脉介入方面的临床工作和研究
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