Article(id=1292126420340339132, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.04.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1767715200000, receivedDateStr=2026-01-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996545156, onlineDateStr=2026-08-06, pubDate=1772208000000, pubDateStr=2026-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996545156, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996545156, creator=13701087609, updateTime=1785996545156, updator=13701087609, issue=Issue{id=1292126355785802497, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996529766, creator='13701087609', updateTime=1786014519902, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201811952292026, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201811952292027, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=559, endPage=564, ext={EN=ArticleExt(id=1292126420562637245, articleId=1292126420340339132, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on the relationship between MMP-3 and rheumatoid arthritis and the intervention of traditional Chinese medicine, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Rheumatoid arthritis is a multifactorial autoimmune disease with an unknown etiology. In recent years, an increasing number of research findings have indicated that matrix metalloproteinase-3 (MMP-3) is most closely related to the pathogenesis of rheumatoid arthritis and is a key enzyme involved in joint destruction in patients with rheumatoid arthritis. A large number of studies have shown that traditional Chinese medicine can play a role in the prevention and treatment of rheumatoid arthritis by regulating the expression of MMP-3 in rheumatoid arthritis. This article explores the possible molecular mechanisms by which MMP-3 causes rheumatoid arthritis and systematically summarizes the literature on the regulation of MMP-3 by traditional Chinese medicine in the prevention and treatment of rheumatoid arthritis in recent years, with the aim of providing a theoretical basis for the research and clinical treatment of rheumatoid arthritis.

, authors=Hui LI¹, Yong-li ZHAO¹, Xing-wen XIE^{1, 2}, Ning LI^{1, 2}, Peng-cheng SONG¹, Ya-xiong GAO¹, authorsList=Hui LI, Yong-li ZHAO, Xing-wen XIE, Ning LI, Peng-cheng SONG, Ya-xiong GAO, authorCompany=null, correspAuthors=Yong-li ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126420831072702, articleId=1292126420340339132, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=MMP-3与类风湿性关节炎的关系及中医药干预研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

类风湿性关节炎是一种病因不明的多因素自身免疫性疾病。近年来越来越多的研究证据表明类风湿性关节炎与基质金属蛋白酶-3发病关系最为密切，是参与类风湿性关节炎患者关节破坏的关键酶。大量研究表明，中医药可通过调节类风湿性关节炎基质金属蛋白酶-3的表达，起到防治类风湿性关节炎的作用。本文探讨基质金属蛋白酶-3引起类风湿性关节炎的可能分子机制，并对近些年来关于中医药调节基质金属蛋白酶-3防治类风湿性关节炎的文献进行系统归纳总结，以期为类风湿性关节炎的研究和临床治疗提供理论依据。

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李辉（1996-），男，住院医师，主要从事骨伤科疾病的研究

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李辉（1996-），男，住院医师，主要从事骨伤科疾病的研究

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