Article(id=1292126411209330699, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996542980, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996542980, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996542980, creator=13701087609, updateTime=1785996542980, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=178, endPage=184, ext={EN=ArticleExt(id=1292126411398074380, articleId=1292126411209330699, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Expression of METTL3 in cerebrospinal fluids of pediatric patients with medulloblastoma and its correlation with prognosis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the expression of methyltransferase-like 3 (METTL3) in cerebrospinal fluids (CSF) and its correlation with the prognosis of children with medulloblastoma (MB).
Methods Cerebrospinal fluids were collected from MB children. METTL3 protein levels were quantified using the Enzyme-Linked ImmunoSorbent Assay (ELISA) and its correlations with clinicopathological features were analyzed. The prognostic significance was evaluated via the Kaplan-Meier survival curve and Cox proportional hazards regression. Bioinformatics analysis was conducted to assess the association of METTL3 with chemotherapeutic drug sensitivities and functional enrichment of METTL3 in brain tumors.
Results Ki-67 index was the only clinicopathological factor significantly correlated with CSF METTL3 levels (P<0.05). METTL3 high expression group showed superior progression-free survival (PFS) (HR=0.376, 95% CI:0.133-1.064, P<0.05). Cox analysis identified METTL3 expression as an independent prognostic factor for PFS (P<0.05). Significant negative correlations between METTL3 expression and 50% inhibitory concentrations (IC50) of methotrexate/vinblastine/etoposide (P<0.001). Gene enrichment revealed METTL3′s involvement in neural development and Notch signaling pathways.
Conclusion METTL3 might serve as a prognostic biomarker for MB pediatric patients. Further validation with expanded cohorts and mechanistic studies (in vivo/in vitro) is warranted.
, authors=Si-han LIU
1, 2, Miao LI
1, 3, Shu-mei WANG
1, authorsList=Si-han LIU, Miao LI, Shu-mei WANG, authorCompany=null, correspAuthors=Shu-mei WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126411620372493, articleId=1292126411209330699, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=髓母细胞瘤患儿脑脊液METTL3表达与预后的相关性研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 考察甲基转移酶样3（METTL3）在髓母细胞瘤（MB）患儿脑脊液中的表达及其与预后的相关性。
方法 收集MB患儿脑脊液，应用酶联免疫吸附测定法（ELISA）检测METTL3蛋白浓度，分析其与临床病理特征相关性；采用Kaplan-Meier生存曲线和Cox比例风险回归分析METTL3的预后意义；采用生物信息学分析METTL3与MB患儿常用化疗药物敏感性的关系，以及METTL3在脑瘤中的功能富集。
结果 Ki-67指数是与脑脊液METTL3表达显著相关的唯一影响因素（P<0.05），METTL3高表达组的无进展生存期（PFS）显著优于低表达组（HR=0.376，95% CI：0.133~1.064，P<0.05）。Cox比例风险回归分析显示，METTL3表达水平是MB患儿PFS的独立影响因素（P<0.05）。脑瘤患者METTL3基因表达与甲氨蝶呤、长春碱、依托泊苷半数抑制浓度（IC50）显著负相关（P<0.001）。基因富集分析揭示METTL3与神经发育及Notch信号通路的相关性。
结论 METTL3可能成为MB患儿的预后标志物，未来需要扩大样本量验证其作用，结合体内和体外实验深入探索其分子机制。
, authors=刘思涵
1, 2, 李苗
1, 3, 王淑梅
1, authorsList=刘思涵, 李苗, 王淑梅, authorCompany=null, correspAuthors=王淑梅, authorNote=
刘思涵（2000-）女，硕士研究生，从事临床药学相关的研究
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