Article(id=1292126359069946804, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.04.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751990400000, receivedDateStr=2025-07-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996530549, onlineDateStr=2026-08-06, pubDate=1772208000000, pubDateStr=2026-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996530549, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996530549, creator=13701087609, updateTime=1785996530549, updator=13701087609, issue=Issue{id=1292126355785802497, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996529766, creator='13701087609', updateTime=1786014519902, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201811952292026, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201811952292027, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=479, endPage=485, ext={EN=ArticleExt(id=1292126359384519605, articleId=1292126359069946804, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of safety of oral resin for treatment of hyperkalemia in Chinese patients with renal insufficiency, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To evaluate the safety, tolerability, treatment patterns, and effectiveness of calcium polystyrene sulfonate (CPS) and sodium polystyrene sulfonate (SPS) in the management of hyperkalemia (HK) among Chinese patients with renal insufficiency.

Methods

Patients with chronic kidney disease (CKD) or acute kidney injury (AKI) with HK in 26 hospitals in China were included in the study. Two full analysis sets (FAS), FAS-P1 (stage 1, followed up for 3 days) and FAS-P2 (stage 2, followed up for 6 months) were defined. Fas-P1 includes all new users taking at least one dose of CPS/SPS 1-3 days after the initial treatment of CPS/SPS, FAS-P2 includes all patients receiving at least one dose of CPS/SPS after enrollment in the user group, and patients receiving at least one dose of CPS/SPS after the initial treatment period in the new user (Fas-P1). The drug use, serum potassium (sK+) level and clinical efficacy of the two data sets were observed, and the safety was evaluated.

Results

A total of 892 patients were selected in the study. 390 patients (CPS 385 cases, SPS 5 cases) and 814 patients (CPS 811 cases, SPS 3 cases) were included in FAS-P1 and FAS-P2, respectively. In FAS-P1 and FAS-P2, the average daily doses of CPS were (7.28±6.24) and (5.13±5.15) g, respectively; and the average daily doses of SPS were (10.75±6.23) and (8.36±7.59) g, respectively. In FAS-P1, the change of sK+ from baseline to day 3 was (-0.72±0.61) mmol·L-1; in FAS-P2, the mean value of sK+ was (5.17±0.68) mmol·L-1 (95% CI: 5.12-5.22). In FAS-P1 and FAS-P2, 56.15% and 55.16% patients had adverse events (AEs), respectively, and the incidence of serious adverse events (SAEs) were 29.23% and 29.24%, respectively. The researchers determined that the incidence of adverse events related to CPS/SPS was low, which was 2.56% in FAS-P1 and 2.09% in FAS-P2. The most common CPS/SPS related AEs were gastrointestinal discomfort (FAS-P1: 2.05%; FAS-P2: 1.70/100 person years) and hypokalemia (FAS-P1: 0.51%; FAS-P2: 2.10/100 person years).

Conclusion

In this study, over 50% of patients with renal insufficiency and hyperkalemia experienced AEs, reflecting the high burden of underlying disease in this population. However, the incidence of AEs related to CPS/SPS was low (approximately 2%), predominantly presenting as gastrointestinal discomfort and hypokalemia.

, authors=Xin-jü ZHAO1, Qiao-ping ZHAO2, Yong-wu YÜ3, Ling WU4, Rong LI5, Ming WANG6, Qun LUO7, Yi-lun ZHOU8, Bing LIU9, Wen-juan QIAN10, Wen-hong SHAN11, Jian-gen YÜ12, Qing-ling ZOU13, Si-yuan TENG14, Ying-chun MA15, Wei-ping WANG16, Tao YANG17, Li-hong ZHANG18, Wei LI19, Ren-huan YÜ20, Li LIU21, Jun SHI22, Li TANG23, Yong-qiang WANG24, Song WANG25, Jing-wei ZHOU26, Li ZUO1, authorsList=Xin-jü ZHAO, Qiao-ping ZHAO, Yong-wu YÜ, Ling WU, Rong LI, Ming WANG, Qun LUO, Yi-lun ZHOU, Bing LIU, Wen-juan QIAN, Wen-hong SHAN, Jian-gen YÜ, Qing-ling ZOU, Si-yuan TENG, Ying-chun MA, Wei-ping WANG, Tao YANG, Li-hong ZHANG, Wei LI, Ren-huan YÜ, Li LIU, Jun SHI, Li TANG, Yong-qiang WANG, Song WANG, Jing-wei ZHOU, Li ZUO, authorCompany=null, correspAuthors=Li ZUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126359627789238, articleId=1292126359069946804, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=口服降钾树脂在中国肾功能不全患者高钾血症中使用的安全性研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

评估聚苯乙烯磺酸钙(CPS)和聚苯乙烯磺酸钠(SPS)在中国肾功能不全患者高钾血症(HK)治疗中的安全性、耐受性、治疗模式和有效性。

方法

以中国26家医院有HK的慢性肾病(CKD)或急性肾损伤(AKI)患者纳入为研究对象。研究共定义2个全分析集(FAS),FAS-P1(阶段1,随访3 d)和FAS-P2(阶段2,随访6个月)。FAS-P1包括在CPS/SPS起始治疗后1~3 d服用至少1剂CPS/SPS的所有新使用者,FAS-P2包括正在使用者组中入组后至少接受1剂CPS/SPS的所有患者,以及新使用者(FAS-P1)中起始治疗期完成后至少接受1剂CPS/SPS的患者。观察2个数据集的用药情况、血清钾(sK+)水平及临床疗效,并进行安全性评价。

结果

研究共筛选892例患者,FAS-P1和FAS-P2分别纳入390例(CPS 385例,SPS 5例)和814例(CPS 811例,SPS 3例)患者。FAS-P1和FAS-P2中,患者的CPS日均剂量分别为(7.28±6.24)和(5.13±5.15)g,SPS日均剂量分别为(10.75±6.23)和(8.36±7.59)g。FAS-P1中,sK+从基线至第3天的变化值为(-0.72±0.61)mmol·L-1;FAS-P2中,研究期间患者sK+均值为(5.17±0.68)mmol·L-1(95% CI:5.12~5.22)。FAS-P1和FAS-P2中,分别有56.15%和55.16%的患者发生了不良事件(AEs),严重不良事件(SAEs)发生率分别为29.23%和29.24%。经研究者判定与CPS/SPS相关的不良事件发生率较低,在FAS-P1和FAS-P2中分别为2.56%和2.09%。最常见的CPS/SPS相关AE为胃肠道不适(FAS-P1:2.05%;FAS-P2:1.70/100人-年)和低钾血症(FAS-P1:0.51%;FAS-P2:2.10/100人-年)。

结论

本研究中,超过50%的肾功能不全合并高钾血症患者发生了AEs,反映了该人群疾病负担较重。但与CPS/SPS相关的AEs发生率较低(约2%),主要表现为胃肠道不适和低钾血症。

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赵新菊(1980-),女,主任医师,主要从事肾病方向的临床工作和相关研究

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左力,主任医师,博士生导师 MP: 13910028495 E-mail:
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口服降钾树脂在中国肾功能不全患者高钾血症中使用的安全性研究
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赵新菊 1 , 赵巧萍 2 , 余永武 3 , 吴岭 4 , 李荣 5 , 王鸣 6 , 罗群 7 , 周亦伦 8 , 刘冰 9 , 钱文娟 10 , 单文红 11 , 於建根 12 , 邹庆玲 13 , 滕思远 14 , 马迎春 15 , 王维平 16 , 杨涛 17 , 张丽红 18 , 李伟 19 , 余仁欢 20 , 刘莉 21 , 时军 22 , 唐莉 23 , 王永强 24 , 王松 25 , 周静威 26 , 左力 1
中国临床药理学杂志 | 临床与基础桥接研究 2026,42(4): 479-485
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中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (4) : 479 -485
口服降钾树脂在中国肾功能不全患者高钾血症中使用的安全性研究
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赵新菊1, 赵巧萍2, 余永武3, 吴岭4, 李荣5, 王鸣6, 罗群7, 周亦伦8, 刘冰9, 钱文娟10, 单文红11, 於建根12, 邹庆玲13, 滕思远14, 马迎春15, 王维平16, 杨涛17, 张丽红18, 李伟19, 余仁欢20, 刘莉21, 时军22, 唐莉23, 王永强24, 王松25, 周静威26, 左力1
作者信息
  • 1.北京大学 人民医院 肾内科,北京 100044
  • 2.东阳市中医院 肾内科,浙江 东阳 322100
  • 3.北京市垂杨柳医院 肾内科,北京 100022
  • 4.徐州市中心医院 肾内科,江苏 徐州 221009
  • 5.天津医科大学 第二医院 肾内科,天津 300211
  • 6.浙江大学 医学院 附属杭州市第一人民医院 肾内科,浙江 杭州 310006
  • 7.中国科学院大学 宁波华美医院 肾内科,浙江 宁波 315010
  • 8.首都医科大学 附属北京天坛医院 肾内科,北京 100070
  • 9.河北省人民医院 肾内科,河北 石家庄 050051
  • 10.张家港市第一人民医院 肾内科,江苏 张家港 215600
  • 11.康复大学 青岛中心医院 肾内科,山东 青岛 266000
  • 12.杭州市萧山区第一人民医院 肾内科,浙江 杭州 311200
  • 13.树兰(杭州)医院 肾脏病科,浙江 杭州 310006
  • 14.大连医科大学 附属第二医院 肾内科,辽宁 大连 116000
  • 15.中国康复研究中心北京博爱医院 肾内科,北京 100068
  • 16.扬州大学 附属扬州市江都人民医院 肾内科,江苏 扬州 225200
  • 17.北京市中关村医院 肾内科,北京 100080
  • 18.河北医科大学 第一医院 肾内科,河北 石家庄 050031
  • 19.山东中医药大学 附属医院 肾病科,山东 济南 250011
  • 20.中国中医科学院 西苑医院 肾病科,北京 100091
  • 21.合肥市第二人民医院/安徽医科大学 附属合肥医院 肾内科,安徽 合肥 230011
  • 22.河南大学 淮河医院 肾内科,河南 开封 475000
  • 23.宁波市鄞州区第二医院 肾移植中心,浙江 宁波 315192
  • 24.新郑华信民生医院 肾病内分泌科,河南 新郑 451100
  • 25.北京大学 第三医院 肾内科,北京 100191
  • 26.北京中医药大学 东直门医院 肾病科,北京 100700
通讯作者:
左力,主任医师,博士生导师 MP: 13910028495 E-mail:
作者简介:

赵新菊(1980-),女,主任医师,主要从事肾病方向的临床工作和相关研究

Clinical trial of safety of oral resin for treatment of hyperkalemia in Chinese patients with renal insufficiency
Xin-jü ZHAO1, Qiao-ping ZHAO2, Yong-wu YÜ3, Ling WU4, Rong LI5, Ming WANG6, Qun LUO7, Yi-lun ZHOU8, Bing LIU9, Wen-juan QIAN10, Wen-hong SHAN11, Jian-gen YÜ12, Qing-ling ZOU13, Si-yuan TENG14, Ying-chun MA15, Wei-ping WANG16, Tao YANG17, Li-hong ZHANG18, Wei LI19, Ren-huan YÜ20, Li LIU21, Jun SHI22, Li TANG23, Yong-qiang WANG24, Song WANG25, Jing-wei ZHOU26, Li ZUO1
Affiliations
  • 1.Department of Nephrology, Peking University People’s Hospital, Beijing 100044, China
  • 2.Department of Nephrology, Dongyang Hospital of Traditional Chinese Medicine, Dongyang 322100, Zhejiang Province, China
  • 3.Department of Nephrology, Beijing Chuiyangliu Hospital, Beijing 100022, China
  • 4.Department of Nephrology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China
  • 5.Department of Nephrology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • 6.Department of Nephrology, Hangzhou First People’s Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China
  • 7.Department of Nephrology, Ningbo Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, Zhejiang Province, China
  • 8.Department of Nephrology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • 9.Department of Nephrology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
  • 10.Department of Nephrology, Zhangjiagang First People’s Hospital, Zhangjiagang 215600, Jiangsu Province, China
  • 11.Department of Nephrology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao 266000, Shandong Province, China
  • 12.Department of Nephrology, Xiaoshan First People’s Hospital, Hangzhou 311200, Zhejiang Province, China
  • 13.Department of Nephrology, Shulan (Hangzhou) Hospital, Hangzhou 310006, Zhejiang Province, China
  • 14.Department of Nephrology, The Second Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
  • 15.Department of Nephrology, Beijing Boai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • 16.Department of Nephrology, Yangzhou Jiangdu People’s Hospital Affiliated to Yangzhou University, Yangzhou 225200, Jiangsu Province, China
  • 17.Department of Nephrology, Beijing Zhongguancun Hospital, Beijing 100080, China
  • 18.Department of Nephrology, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China
  • 19.Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong Province, China
  • 20.Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
  • 21.Department of Nephrology, Second People’s Hospital of Hefei / Hefei Hospital Affiliated to Anhui Medical University, Hefei 230011, Anhui Province, China
  • 22.Department of Nephrology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan Province, China
  • 23.Department of Kidney Transplant Center, Yinzhou NO.2 Hospital, Ningbo 315192, Zhejiang Province, China
  • 24.Department of Nephrology and Endocrinology, Hopeshine-Mingsheng Hospital of Xinzheng, Xinzheng 451100, Henan Province, China
  • 25.Department of Nephrology, Peking University Third Hospital, Beijing 100191, China
  • 26.Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
出版时间: 2026-02-28 doi: 10.13699/j.cnki.1001-6821.2026.04.005
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目的

评估聚苯乙烯磺酸钙(CPS)和聚苯乙烯磺酸钠(SPS)在中国肾功能不全患者高钾血症(HK)治疗中的安全性、耐受性、治疗模式和有效性。

方法

以中国26家医院有HK的慢性肾病(CKD)或急性肾损伤(AKI)患者纳入为研究对象。研究共定义2个全分析集(FAS),FAS-P1(阶段1,随访3 d)和FAS-P2(阶段2,随访6个月)。FAS-P1包括在CPS/SPS起始治疗后1~3 d服用至少1剂CPS/SPS的所有新使用者,FAS-P2包括正在使用者组中入组后至少接受1剂CPS/SPS的所有患者,以及新使用者(FAS-P1)中起始治疗期完成后至少接受1剂CPS/SPS的患者。观察2个数据集的用药情况、血清钾(sK+)水平及临床疗效,并进行安全性评价。

结果

研究共筛选892例患者,FAS-P1和FAS-P2分别纳入390例(CPS 385例,SPS 5例)和814例(CPS 811例,SPS 3例)患者。FAS-P1和FAS-P2中,患者的CPS日均剂量分别为(7.28±6.24)和(5.13±5.15)g,SPS日均剂量分别为(10.75±6.23)和(8.36±7.59)g。FAS-P1中,sK+从基线至第3天的变化值为(-0.72±0.61)mmol·L-1;FAS-P2中,研究期间患者sK+均值为(5.17±0.68)mmol·L-1(95% CI:5.12~5.22)。FAS-P1和FAS-P2中,分别有56.15%和55.16%的患者发生了不良事件(AEs),严重不良事件(SAEs)发生率分别为29.23%和29.24%。经研究者判定与CPS/SPS相关的不良事件发生率较低,在FAS-P1和FAS-P2中分别为2.56%和2.09%。最常见的CPS/SPS相关AE为胃肠道不适(FAS-P1:2.05%;FAS-P2:1.70/100人-年)和低钾血症(FAS-P1:0.51%;FAS-P2:2.10/100人-年)。

结论

本研究中,超过50%的肾功能不全合并高钾血症患者发生了AEs,反映了该人群疾病负担较重。但与CPS/SPS相关的AEs发生率较低(约2%),主要表现为胃肠道不适和低钾血症。

口服降钾树脂  /  高钾血症  /  肾功能不全  /  安全性  /  治疗模式
Objective

To evaluate the safety, tolerability, treatment patterns, and effectiveness of calcium polystyrene sulfonate (CPS) and sodium polystyrene sulfonate (SPS) in the management of hyperkalemia (HK) among Chinese patients with renal insufficiency.

Methods

Patients with chronic kidney disease (CKD) or acute kidney injury (AKI) with HK in 26 hospitals in China were included in the study. Two full analysis sets (FAS), FAS-P1 (stage 1, followed up for 3 days) and FAS-P2 (stage 2, followed up for 6 months) were defined. Fas-P1 includes all new users taking at least one dose of CPS/SPS 1-3 days after the initial treatment of CPS/SPS, FAS-P2 includes all patients receiving at least one dose of CPS/SPS after enrollment in the user group, and patients receiving at least one dose of CPS/SPS after the initial treatment period in the new user (Fas-P1). The drug use, serum potassium (sK+) level and clinical efficacy of the two data sets were observed, and the safety was evaluated.

Results

A total of 892 patients were selected in the study. 390 patients (CPS 385 cases, SPS 5 cases) and 814 patients (CPS 811 cases, SPS 3 cases) were included in FAS-P1 and FAS-P2, respectively. In FAS-P1 and FAS-P2, the average daily doses of CPS were (7.28±6.24) and (5.13±5.15) g, respectively; and the average daily doses of SPS were (10.75±6.23) and (8.36±7.59) g, respectively. In FAS-P1, the change of sK+ from baseline to day 3 was (-0.72±0.61) mmol·L-1; in FAS-P2, the mean value of sK+ was (5.17±0.68) mmol·L-1 (95% CI: 5.12-5.22). In FAS-P1 and FAS-P2, 56.15% and 55.16% patients had adverse events (AEs), respectively, and the incidence of serious adverse events (SAEs) were 29.23% and 29.24%, respectively. The researchers determined that the incidence of adverse events related to CPS/SPS was low, which was 2.56% in FAS-P1 and 2.09% in FAS-P2. The most common CPS/SPS related AEs were gastrointestinal discomfort (FAS-P1: 2.05%; FAS-P2: 1.70/100 person years) and hypokalemia (FAS-P1: 0.51%; FAS-P2: 2.10/100 person years).

Conclusion

In this study, over 50% of patients with renal insufficiency and hyperkalemia experienced AEs, reflecting the high burden of underlying disease in this population. However, the incidence of AEs related to CPS/SPS was low (approximately 2%), predominantly presenting as gastrointestinal discomfort and hypokalemia.

oral potassium-exchange resin  /  hyperkalemia  /  renal insufficiency  /  safety  /  treatment pattern
赵新菊, 赵巧萍, 余永武, 吴岭, 李荣, 王鸣, 罗群, 周亦伦, 刘冰, 钱文娟, 单文红, 於建根, 邹庆玲, 滕思远, 马迎春, 王维平, 杨涛, 张丽红, 李伟, 余仁欢, 刘莉, 时军, 唐莉, 王永强, 王松, 周静威, 左力. 口服降钾树脂在中国肾功能不全患者高钾血症中使用的安全性研究. 中国临床药理学杂志, 2026 , 42 (4) : 479 -485 . DOI: 10.13699/j.cnki.1001-6821.2026.04.005
Xin-jü ZHAO, Qiao-ping ZHAO, Yong-wu YÜ, Ling WU, Rong LI, Ming WANG, Qun LUO, Yi-lun ZHOU, Bing LIU, Wen-juan QIAN, Wen-hong SHAN, Jian-gen YÜ, Qing-ling ZOU, Si-yuan TENG, Ying-chun MA, Wei-ping WANG, Tao YANG, Li-hong ZHANG, Wei LI, Ren-huan YÜ, Li LIU, Jun SHI, Li TANG, Yong-qiang WANG, Song WANG, Jing-wei ZHOU, Li ZUO. Clinical trial of safety of oral resin for treatment of hyperkalemia in Chinese patients with renal insufficiency[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (4) : 479 -485 . DOI: 10.13699/j.cnki.1001-6821.2026.04.005
  • 本研究由阿斯利康投资(中国)有限公司资助(D9483R00002)
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文章信息
doi: 10.13699/j.cnki.1001-6821.2026.04.005
  • 接收时间:2025-07-09
  • 首发时间:2026-08-06
  • 出版时间:2026-02-28
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  • 收稿日期:2025-07-09
基金
本研究由阿斯利康投资(中国)有限公司资助(D9483R00002)
作者信息
    1.北京大学 人民医院 肾内科,北京 100044
    2.东阳市中医院 肾内科,浙江 东阳 322100
    3.北京市垂杨柳医院 肾内科,北京 100022
    4.徐州市中心医院 肾内科,江苏 徐州 221009
    5.天津医科大学 第二医院 肾内科,天津 300211
    6.浙江大学 医学院 附属杭州市第一人民医院 肾内科,浙江 杭州 310006
    7.中国科学院大学 宁波华美医院 肾内科,浙江 宁波 315010
    8.首都医科大学 附属北京天坛医院 肾内科,北京 100070
    9.河北省人民医院 肾内科,河北 石家庄 050051
    10.张家港市第一人民医院 肾内科,江苏 张家港 215600
    11.康复大学 青岛中心医院 肾内科,山东 青岛 266000
    12.杭州市萧山区第一人民医院 肾内科,浙江 杭州 311200
    13.树兰(杭州)医院 肾脏病科,浙江 杭州 310006
    14.大连医科大学 附属第二医院 肾内科,辽宁 大连 116000
    15.中国康复研究中心北京博爱医院 肾内科,北京 100068
    16.扬州大学 附属扬州市江都人民医院 肾内科,江苏 扬州 225200
    17.北京市中关村医院 肾内科,北京 100080
    18.河北医科大学 第一医院 肾内科,河北 石家庄 050031
    19.山东中医药大学 附属医院 肾病科,山东 济南 250011
    20.中国中医科学院 西苑医院 肾病科,北京 100091
    21.合肥市第二人民医院/安徽医科大学 附属合肥医院 肾内科,安徽 合肥 230011
    22.河南大学 淮河医院 肾内科,河南 开封 475000
    23.宁波市鄞州区第二医院 肾移植中心,浙江 宁波 315192
    24.新郑华信民生医院 肾病内分泌科,河南 新郑 451100
    25.北京大学 第三医院 肾内科,北京 100191
    26.北京中医药大学 东直门医院 肾病科,北京 100700

通讯作者:

左力,主任医师,博士生导师 MP: 13910028495 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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