Article(id=1291707310636822623, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1766419200000, receivedDateStr=2025-12-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896621616, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896621616, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896621616, creator=13701087609, updateTime=1785896621616, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3309, endPage=3314, ext={EN=ArticleExt(id=1291707310976561248, articleId=1291707310636822623, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of changes and significance of serum diamine oxidase level in patients with gastrointestinal toxicity induced by fluorouracil antineoplastic drugs, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore changes in serum diamine oxidase (DAO) levels and their clinical significance in patients with gastrointestinal toxicity induced by fluorouracil antineoplastic drugs.
Methods Patients with gastrointestinal tumors receiving fluorouracil-based antineoplastic therapy were divided into treatment group and control group according to whether gastrointestinal toxicity occurred during chemotherapy. The treatment group was further subdivided into ≤grade Ⅱ group and grade Ⅲ group based on the severity of gastrointestinal toxicity. General clinical data were collected, and serum DAO levels before chemotherapy and 7 days after chemotherapy were compared between treatment and control groups, as well as among patients with different grades of gastrointestinal toxicity. Logistic regression model was used to analyze the relationship between DAO levels and gastrointestinal toxicity, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of serum DAO levels 7 days after chemotherapy for the occurrence of gastrointestinal toxicity.
Results A total of 50 patients were ultimately included as study subjects, with 26 in treatment group and 24 in control group. The serum DAO levels 7 days after chemotherapy were (14.71±3.44) and (10.89±3.67) U·L-1 in treatment and control groups, respectively. The serum DAO level in treatment group was significantly higher than that in control group 7 days after chemotherapy (P<0.05). The serum DAO levels 7 days after chemotherapy in ≤grade Ⅱ subgroup and grade Ⅲ subgroup were (13.38±3.06) and (16.37±3.25) U·L-1, respectively. The serum DAO level in the ≤grade Ⅱ subgroup was significantly lower than that in the grade Ⅲ subgroup (P<0.05). Multivariate logistic regression analysis indicated that the serum DAO level 7 days after chemotherapy was an influencing factor for the occurrence of gastrointestinal toxicity in patients (P<0.001). ROC curve analysis showed that the optimal threshold for serum DAO in predicting gastrointestinal toxicity after chemotherapy was 11.92 U·L-1, with an area under the curve (AUC) of 0.79 (P<0.05). The sensitivity and specificity were 77.78% and 86.96%, respectively.
Conclusion Chemotherapy with fluorouracil-based antineoplastic drugs can lead to elevated serum DAO levels in patients with gastrointestinal tumors. The serum DAO level is associated with the severity of gastrointestinal toxicity and the grade of adverse drug reactions, and may serve as a predictive indicator for the occurrence of gastrointestinal toxicity following chemotherapy.
, authors=Meng-qin HUANG, Li-xia HU, Cheng-fa LI, Qian-qian YUAN, Yan WU, authorsList=Meng-qin HUANG, Li-xia HU, Cheng-fa LI, Qian-qian YUAN, Yan WU, authorCompany=null, correspAuthors=Meng-qin HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707311278551137, articleId=1291707310636822623, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=氟尿嘧啶类抗肿瘤药物致胃肠道毒性反应患者血清二胺氧化酶水平变化的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究氟尿嘧啶类抗肿瘤药物致胃肠道毒性反应患者的血清二胺氧化酶（DAO）水平变化及其临床意义。
方法 将接受氟尿嘧啶类抗肿瘤药物治疗的消化道肿瘤患者的根据化疗期间是否发生胃肠道毒性反应分为试验组和对照组，并根据胃肠道毒性反应等级将试验组患者分为≤Ⅱ级组和Ⅲ级组；收集患者一般临床资料，比较试验组与对照组间及不同胃肠道毒性反应等级患者间化疗前、化疗后7天的血清DAO水平；用Logistic回归模型分析DAO水平与胃肠道毒性反应的关系，用受试者工作特征（ROC）曲线分析化疗后7天血清DAO水平对患者发生胃肠道毒性反应的预测价值。
结果 最终纳入50例患者作为研究对象，试验组26例，对照组24例。试验组与对照组患者化疗后7天的血清DAO水平分别为（14.71±3.44）和（10.89±3.67）U·L-1，试验组患者化疗后7天的血清DAO水平显著高于对照组（P<0.05）；≤Ⅱ级组与Ⅲ级组化疗后7天的血清DAO水平分别为（13.38±3.06）和（16.37±3.25）U·L-1，≤Ⅱ级组患者化疗后7天的血清DAO水平显著低于Ⅲ级患者（P<0.05）。多因素Logistic回归分析显示，化疗后7天后血清DAO水平是患者发生胃肠道毒性反应的影响因素（P<0.001）；ROC曲线分析显示，血清DAO预测化疗后胃肠道毒性反应的最佳阈值为11.92 U·L-1，曲线下面积（AUC）值为0.79（P<0.05），敏感度、特异度分别为77.78%和86.96%。
结论 氟尿嘧啶类抗肿瘤药物化疗会导致消化道肿瘤患者血清DAO水平升高，血清DAO水平与患者胃肠道毒性反应及药物不良反应等级有关，或可作为化疗后胃肠道毒性反应发生的预测指标。
, authors=黄孟芹, 胡丽霞, 李成发, 袁倩倩, 吴艳, authorsList=黄孟芹, 胡丽霞, 李成发, 袁倩倩, 吴艳, authorCompany=null, correspAuthors=黄孟芹, authorNote=
黄孟芹（1974-），女，本科，副主任医师，主要从事血液肿瘤疾病诊疗方面的临床工作和研究
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