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Article(id=1291707276847505561, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1766937600000, receivedDateStr=2025-12-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896613561, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896613561, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896613561, creator=13701087609, updateTime=1785896613561, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3301, endPage=3308, ext={EN=ArticleExt(id=1291707277334044827, articleId=1291707276847505561, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Association study of CAPN10 rs3792269 and SLC47A2 rs12943590 genetic polymorphisms with metformin efficacy in T2DM patients in Xinjiang region, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the association between CAPN10 rs3792269 and SLC47A2 rs12943590 gene polymorphisms and the efficacy of metformin in type 2 diabetes mellitus (T2DM) patients receiving metformin monotherapy in Xinjiang, providing references for individualized drug therapy in local patients.

Methods

A total of 450 T2DM patients who had been regularly taking metformin monotherapy for ≥3 months from July 2024 to July 2025 in a tertiary hospital in Xinjiang were selected. Clinical data were collected and target locus genotypes were detected. Using glycated hemoglobin (HbA1c%) as the efficacy indicator, patients were divided into wild-type homozygous and mutant genotype groups. Propensity score matching (PSM) was employed to analyze the association between gene polymorphisms and efficacy, followed by post hoc power analysis.

Results

The PSM analysis revealed that the CAPN10 rs3792269 A>G variant was an independent protective factor for good glycemic control (PSM-adjusted OR=0.478, 95%CI 0.266-0.862, P<0.05). In contrast, the SLC47A2 rs12943590 polymorphism showed no significant association with treatment efficacy. For the CAPN10 rs3792269 locus, the absolute difference in glycemic control rates between the two groups was 17.3%, with OR=2.10 and statistical power of approximately 90%. For the SLC47A2 rs12943590 locus, the absolute difference was 2.5%, with OR=0.91 and statistical power of only 7%.

Conclusion

This study clarifies that the CAPN10 rs3792269 A>G variant is significantly associated with improved efficacy of metformin in the Xinjiang population of China, while the SLC47A2 rs12943590 locus shows no association in this sample. The influence of genetic factors on metformin efficacy exhibits population heterogeneity. The sample size in this study provids sufficient power for detecting moderate to large effects, which may serve as a reference for individualized medication and blood glucose management in local patients.

, authors=Yu-lian KOU1, Liang MA2, Mu-yun LI1, Yu-bo WANG3, Wen-ling FENG3, Jie RUAN3, Xiao-li GAO1, 2, 4, Jun ZHAO3, 4, authorsList=Yu-lian KOU, Liang MA, Mu-yun LI, Yu-bo WANG, Wen-ling FENG, Jie RUAN, Xiao-li GAO, Jun ZHAO, authorCompany=null, correspAuthors=Xiao-li GAO, Jun ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707279280201884, articleId=1291707276847505561, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与新疆地区T2DM患者二甲双胍疗效的关联性研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

探究新疆地区单药服用二甲双胍的2型糖尿病（T2DM）患者的CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与二甲双胍疗效的关联，为当地患者的个体化药物治疗提供参考。

方法

选取新疆某三甲医院2024年7月至2025年7月规律单药服用二甲双胍≥3个月的T2DM患者450例，收集临床资料并检测目标位点基因型，以糖化血红蛋白（HbA1c%）作为疗效指标，将患者分为野生纯合型组与突变基因型组，采用倾向性评分匹配（PSM）分析基因多态性与疗效的关联，并行事后功效分析。

结果

PSM分析显示，CAPN10 rs3792269 A>G变异是血糖控制良好的独立保护因素（PSM调整后OR=0.478，95%CI 0.266~0.862，P<0.05）。而SLC47A2 rs12943590多态性与疗效无显著关联。CAPN10 rs3792269位点中两组血糖控制率的绝对差异为17.3%，OR=2.10，统计功效约90%，SLC47A2 rs12943590位点中两组血糖控制率的绝对差异为2.5%，OR=0.91，统计功效仅为7%。

结论

本研究明确了在中国新疆人群中CAPN10 rs3792269 A>G变异与二甲双胍疗效改善显著相关，而SLC47A2 rs12943590位点在本样本中未显示关联。遗传因素对二甲双胍疗效的影响存在人群异质性。本研究样本量对中等及以上效应检验能力充分，可为当地患者个体化用药及血糖管理提供参考。

, authors=寇玉莲1, 马亮2, 李牧云1, 王钰博3, 冯文玲3, 阮洁3, 高晓黎1, 2, 4, 赵军3, 4, authorsList=寇玉莲, 马亮, 李牧云, 王钰博, 冯文玲, 阮洁, 高晓黎, 赵军, authorCompany=null, correspAuthors=高晓黎, 赵军, authorNote=

寇玉莲（2001-）女，硕士研究生，主要从事药物基因组学相关研究

, correspAuthorsNote=
高晓黎，教授，博士生导师 MP: 13609905058 E-mail:
赵军，主任药师，教授 MP: 13079978257 E-mail:
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CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与新疆地区T2DM患者二甲双胍疗效的关联性研究
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寇玉莲 1 , 马亮 2 , 李牧云 1 , 王钰博 3 , 冯文玲 3 , 阮洁 3 , 高晓黎 1, 2, 4 , 赵军 3, 4
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(23): 3301-3308
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中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (23) : 3301 -3308
CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与新疆地区T2DM患者二甲双胍疗效的关联性研究
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寇玉莲1, 马亮2, 李牧云1, 王钰博3, 冯文玲3, 阮洁3, 高晓黎1, 2, 4 , 赵军3, 4
作者信息
  • 1.新疆医科大学 药学院，新疆，乌鲁木齐 830054
  • 2.新疆医科大学，新疆，乌鲁木齐 830054
  • 3.新疆医科大学 第一附属医院 药学部，新疆，乌鲁木齐 830011
  • 4.新疆及中亚特色医药资源教育部工程研究中心，新疆，乌鲁木齐 830054
通讯作者:
高晓黎，教授，博士生导师 MP: 13609905058 E-mail:
赵军，主任药师，教授 MP: 13079978257 E-mail:
作者简介:

寇玉莲（2001-）女，硕士研究生，主要从事药物基因组学相关研究

Association study of CAPN10 rs3792269 and SLC47A2 rs12943590 genetic polymorphisms with metformin efficacy in T2DM patients in Xinjiang region
Yu-lian KOU1, Liang MA2, Mu-yun LI1, Yu-bo WANG3, Wen-ling FENG3, Jie RUAN3, Xiao-li GAO1, 2, 4 , Jun ZHAO3, 4
Affiliations
  • 1.School of Pharmacy, Xinjiang Medical University, Urumqi 830054, Xinjiang, China
  • 2.Xinjiang Medical University, Urumqi 830054, Xinjiang, China
  • 3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China
  • 4.Engineering Research Center of Xinjiang and Central Asia Special Medicine Resources, Ministry of Education, Urumqi 830054, Xinjiang, China
出版时间: 2025-12-17 doi: 10.13699/j.cnki.1001-6821.2025.23.001
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摘要
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目的

探究新疆地区单药服用二甲双胍的2型糖尿病（T2DM）患者的CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与二甲双胍疗效的关联，为当地患者的个体化药物治疗提供参考。

方法

选取新疆某三甲医院2024年7月至2025年7月规律单药服用二甲双胍≥3个月的T2DM患者450例，收集临床资料并检测目标位点基因型，以糖化血红蛋白（HbA1c%）作为疗效指标，将患者分为野生纯合型组与突变基因型组，采用倾向性评分匹配（PSM）分析基因多态性与疗效的关联，并行事后功效分析。

结果

PSM分析显示，CAPN10 rs3792269 A>G变异是血糖控制良好的独立保护因素（PSM调整后OR=0.478，95%CI 0.266~0.862，P<0.05）。而SLC47A2 rs12943590多态性与疗效无显著关联。CAPN10 rs3792269位点中两组血糖控制率的绝对差异为17.3%，OR=2.10，统计功效约90%，SLC47A2 rs12943590位点中两组血糖控制率的绝对差异为2.5%，OR=0.91，统计功效仅为7%。

结论

本研究明确了在中国新疆人群中CAPN10 rs3792269 A>G变异与二甲双胍疗效改善显著相关，而SLC47A2 rs12943590位点在本样本中未显示关联。遗传因素对二甲双胍疗效的影响存在人群异质性。本研究样本量对中等及以上效应检验能力充分，可为当地患者个体化用药及血糖管理提供参考。

二甲双胍  /  2型糖尿病  /  血糖控制  /  基因多态性  /  新疆人群
Objective

To investigate the association between CAPN10 rs3792269 and SLC47A2 rs12943590 gene polymorphisms and the efficacy of metformin in type 2 diabetes mellitus (T2DM) patients receiving metformin monotherapy in Xinjiang, providing references for individualized drug therapy in local patients.

Methods

A total of 450 T2DM patients who had been regularly taking metformin monotherapy for ≥3 months from July 2024 to July 2025 in a tertiary hospital in Xinjiang were selected. Clinical data were collected and target locus genotypes were detected. Using glycated hemoglobin (HbA1c%) as the efficacy indicator, patients were divided into wild-type homozygous and mutant genotype groups. Propensity score matching (PSM) was employed to analyze the association between gene polymorphisms and efficacy, followed by post hoc power analysis.

Results

The PSM analysis revealed that the CAPN10 rs3792269 A>G variant was an independent protective factor for good glycemic control (PSM-adjusted OR=0.478, 95%CI 0.266-0.862, P<0.05). In contrast, the SLC47A2 rs12943590 polymorphism showed no significant association with treatment efficacy. For the CAPN10 rs3792269 locus, the absolute difference in glycemic control rates between the two groups was 17.3%, with OR=2.10 and statistical power of approximately 90%. For the SLC47A2 rs12943590 locus, the absolute difference was 2.5%, with OR=0.91 and statistical power of only 7%.

Conclusion

This study clarifies that the CAPN10 rs3792269 A>G variant is significantly associated with improved efficacy of metformin in the Xinjiang population of China, while the SLC47A2 rs12943590 locus shows no association in this sample. The influence of genetic factors on metformin efficacy exhibits population heterogeneity. The sample size in this study provids sufficient power for detecting moderate to large effects, which may serve as a reference for individualized medication and blood glucose management in local patients.

metformin  /  type 2 diabetes  /  glycemic control  /  gene polymorphism  /  Xinjiang population
寇玉莲, 马亮, 李牧云, 王钰博, 冯文玲, 阮洁, 高晓黎, 赵军. CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与新疆地区T2DM患者二甲双胍疗效的关联性研究. 中国临床药理学杂志, 2025 , 41 (23) : 3301 -3308 . DOI: 10.13699/j.cnki.1001-6821.2025.23.001
Yu-lian KOU, Liang MA, Mu-yun LI, Yu-bo WANG, Wen-ling FENG, Jie RUAN, Xiao-li GAO, Jun ZHAO. Association study of CAPN10 rs3792269 and SLC47A2 rs12943590 genetic polymorphisms with metformin efficacy in T2DM patients in Xinjiang region[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (23) : 3301 -3308 . DOI: 10.13699/j.cnki.1001-6821.2025.23.001
基金
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  • “天山英才”医药卫生高层次人才培养计划(TSYC202301A051)
  • 新疆天然药物活性组分与释药技术重点实验室重点项目(2025XJTRZ03)
  • 新疆及中亚特色医药资源教育部工程研究中心定向资助项目(GC2X2024-03)
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文章信息
doi: 10.13699/j.cnki.1001-6821.2025.23.001
  • 接收时间：2025-12-29
  • 首发时间：2026-08-05
  • 出版时间：2025-12-17
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  • 收稿日期：2025-12-29
基金
“天山英才”医药卫生高层次人才培养计划(TSYC202301A051)
新疆天然药物活性组分与释药技术重点实验室重点项目(2025XJTRZ03)
新疆及中亚特色医药资源教育部工程研究中心定向资助项目(GC2X2024-03)
作者信息
    1.新疆医科大学 药学院，新疆，乌鲁木齐 830054
    2.新疆医科大学，新疆，乌鲁木齐 830054
    3.新疆医科大学 第一附属医院 药学部，新疆，乌鲁木齐 830011
    4.新疆及中亚特色医药资源教育部工程研究中心，新疆，乌鲁木齐 830054

通讯作者:

高晓黎，教授，博士生导师 MP: 13609905058 E-mail:
赵军，主任药师，教授 MP: 13079978257 E-mail:
参考文献
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.23.001
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2种不同金属材料的力学参数
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species		 占总种数比例
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total species (%)		 属
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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