Article(id=1291707206135735221, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.22.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758988800000, receivedDateStr=2025-09-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896596701, onlineDateStr=2026-08-05, pubDate=1764259200000, pubDateStr=2025-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896596701, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896596701, creator=13701087609, updateTime=1785896596701, updator=13701087609, issue=Issue{id=1291707004800750583, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='22', pageStart='3151', pageEnd='3300', issueExtLink='null', onlineDate='null', pubDate='1764259200000', pubDateStr='2025-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896548700, creator='13701087609', updateTime=1785896693213, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707610999316815, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707610999316816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3277, endPage=3283, ext={EN=ArticleExt(id=1291707207863788470, articleId=1291707206135735221, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress of novel polymyxin derivatives, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Polymyxin’s clinical application is limited by its significant nephrotoxicity, complex pharmacokinetic and pharmacodynamic characteristics, and the growing issue of bacterial resistance. This systematic review summarizes research progress on three novel polymyxin derivatives: SPR206, QPX9003, and MRX-8. Through structural design, these compounds retain potent antimicrobial activity while reducing nephrotoxicity and improving PK/PD profiles. Preclinical studies and preliminary clinical trials demonstrate broad-spectrum antimicrobial activity against multidrug-resistant Gram-negative bacteria, along with promising efficacy in models such as pulmonary infections. Although these candidate drugs are still undergoing clinical trials, they show potential to become alternatives to existing polymyxin therapies.

, authors=Shi-zhuo LIU, Ze-xuan TIAN, Ying-chao MA, Xiu-ling YANG, authorsList=Shi-zhuo LIU, Ze-xuan TIAN, Ying-chao MA, Xiu-ling YANG, authorCompany=null, correspAuthors=Xiu-ling YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707208128029623, articleId=1291707206135735221, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=新型多黏菌素衍生物的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

多黏菌素因其显著的肾毒性、复杂的药动力学/药效学特性以及日益出现的细菌耐药性问题限制了其临床应用。本文综述了三种新型多黏菌素衍生物：SPR206、QPX9003和MRX-8的研究进展，这些药物通过药物化学结构设计，在保留强效抗菌活性的同时，降低了肾毒性，改善了PK/PD特性。临床前和初步临床研究显示，它们对多重耐药革兰阴性菌具有较强抗菌活性，且在肺部感染模型中表现出良好疗效。虽然这些候选药物尚在临床试验阶段，但它们展现出成为现有多黏菌素替代方案的潜力。

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刘世卓（2000-），女，硕士研究生，主要从事临床药学研究

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刘世卓（2000-），女，硕士研究生，主要从事临床药学研究

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