Article(id=1291707181011854146, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1763395200000, receivedDateStr=2025-11-18, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896590712, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896590712, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896590712, creator=13701087609, updateTime=1785896590712, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3562, endPage=3566, ext={EN=ArticleExt(id=1291707181557113667, articleId=1291707181011854146, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the myocardial protective effect of esmolol in perioperative non-cardiac major surgery, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

The prevention and treatment of perioperative myocardial injury primarily rely on hemodynamic management and conventional cardiovascular medications, yet limitations remain, such as constraints in intervention timing, significant individual response variability, and the irreversible effects or notable adverse reactions associated with some drugs. As an ultra-short-acting, highly selective β1-receptor blocker, esmolol offers rapid onset, a short half-life, and precise controllability. It not only effectively stabilizes heart rate and blood pressure but may also exert myocardial protective effects through multiple pathways, including regulating myocardial oxygen supply-demand balance, suppressing inflammatory responses, and mitigating cellular apoptosis. This article reviews recent domestic and international studies, summarizing the mechanisms of perioperative myocardial injury, the myocardial protective effects of esmolol, and its potential molecular pathways. The aim is to provide new perspectives and a theoretical basis for optimizing perioperative cardiac protection strategies.

, authors=Min ZOU, Jing CAO, Ling DONG, Xiao-ling YANG, Xiu-mei SONG, authorsList=Min ZOU, Jing CAO, Ling DONG, Xiao-ling YANG, Xiu-mei SONG, authorCompany=null, correspAuthors=Xiu-mei SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707182123344708, articleId=1291707181011854146, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=艾司洛尔用于围术期非心脏大手术的心肌保护作用的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

围术期心肌损伤的防治主要依赖于血流动力学管理与传统心血管药物，但仍存在干预时机局限、个体反应差异大、部分药物作用不可逆或药物不良反应显著等不足。艾司洛尔作为超短效高选择性β1受体阻滞剂，以其起效迅速、半衰期短、可精确调控的优势，不仅可有效稳定心率与血压，更可能通过调节心肌氧供需平衡、抑制炎症反应、减轻细胞凋亡等多途径发挥心肌保护作用。本文通过梳理近年国内外相关研究，从围术期心肌损伤的机制、艾司洛尔的心肌保护效应及其潜在分子通路等方面进行综述，旨在为围术期心脏保护策略的优化提供新视角与理论依据。

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邹敏（2001-），女，硕士研究生，主要从事围术期脏器保护的相关研究

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邹敏（2001-），女，硕士研究生，主要从事围术期脏器保护的相关研究

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