Article(id=1291707168034673313, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1761062400000, receivedDateStr=2025-10-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896587618, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896587618, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896587618, creator=13701087609, updateTime=1785896587618, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3408, endPage=3414, ext={EN=ArticleExt(id=1291707168642847394, articleId=1291707168034673313, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Exploring the mechanism of action of Danyu Hemai Granules for hypertension treatment
via network pharmacology and molecular docking, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the mechanism of professor Fu Deyu’s core prescription, Danyu Hemai Granules (DYHMG), in treating hypertension using network pharmacology, and to conduct preliminary validation through molecular docking technology.
Methods Active components and targets of Danyu Hemai Granules were screened with traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), traditional Chinese medicine integrated database (TCMID), and HERB database. Hypertension-related targets were retrieved from GeneCards and OMIM. Intersection targets were identified, and protein-protein interaction (PPI) networks were constructed via STRING. The "Herb-Active Component-Target-Disease" network was visualized using Cytoscape to identify core targets. GO and KEGG pathway enrichment analyses were performed with Metascape. Finally, molecular docking validation was performed between key active components and core targets.
Results A total of 127 active ingredients and 312 targets of DYHMG, and 5 251 hypertension-related targets were identified, resulting in 229 common targets. Analysis suggested DYHMG exerts its antihypertensive effects primarily through active ingredients such as quercetin, kaempferol, luteolin, beta-sitosterol, stigmasterol, and wogonin. These ingredients acted on core targets including signal transducer and activator of transcription 3 (STAT3), RAC-alpha serine/threonine-protein kinase (AKT1), and estrogen receptor alpha (ESR1). Key pathways involved were lipid and atherosclerosis, the HIF-1 signaling pathway, insulin resistance, calcium signaling pathway, cAMP signaling pathway, MAPK signaling pathway, necroptosis, the renin-angiotensin system (RAS), and efferocytosis pathways.
Conclusion Danyu Hemai Granules exhibits the characteristics of multi-component, multi-target, and multi-pathway in the treatment of hypertension. This study can provide ideas for the in-depth research on Danyu Hemai Granules in the treatment of hypertension and offer a scientific basis for its rational clinical application.
, authors=Jia-ying ZHU, De-yu FU, Yu-xiu ZHAO, Yu-long MA, Bo-ying CAO, Xiao-zhe CHEN, Si-yu SUN, Bo LU, authorsList=Jia-ying ZHU, De-yu FU, Yu-xiu ZHAO, Yu-long MA, Bo-ying CAO, Xiao-zhe CHEN, Si-yu SUN, Bo LU, authorCompany=null, correspAuthors=Bo LU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707169041306275, articleId=1291707168034673313, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于网络药理学和分子对接探讨丹玉和脉颗粒治疗高血压的作用机制, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 运用网络药理学研究符德玉教授治疗高血压核心处方丹玉和脉颗粒的作用机制，并通过分子对接技术进行初步验证。
方法 通过中药系统药理学数据库与分析平台（TCMSP）、中医药综合数据库（TCMID）及本草组鉴数据库（HERB），筛选丹玉和脉颗粒有效成分及潜在作用靶点；利用GeneCards、人类孟德尔遗传在线数据库检索高血压相关基因靶点，取两者交集靶点。借助STRING数据库构建蛋白质互作网络，利用Cytoscape筛选核心作用靶点。运用Metascape数据库对交集靶点进行GO及KEGG分析。最后对有效成分与核心靶点进行分子对接验证。
结果 共获得丹玉和脉颗粒有效成分127种，靶点312个，高血压靶点5 251个，交集靶点229个；丹玉和脉颗粒主要通过槲皮素、山奈酚、木犀草素等有效成分作用于转导与转录激活因子3（STAT3）、RAC-α丝氨酸/苏氨酸蛋白激酶（AKT1）、雌激素受体（ESR1）等，通过脂质与动脉粥样硬化、HIF-1信号通路、胰岛素抵抗、钙信号通路、cAMP信号通路、MAPK信号通路、坏死性凋亡、肾素-血管紧张素系统等相关通路等发挥治疗高血压的作用。
结论 丹玉和脉颗粒治疗高血压具有多成分-多靶点-多通路的特点，该研究可为丹玉和脉颗粒治疗高血压病的深入研究提供思路，并为其临床合理应用提供科学依据。
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朱家颖（1999-），男，硕士研究生，主要从事中西医结合防治心血管疾病方面的研究
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