Article(id=1291707141950296663, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.23.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1755100800000, receivedDateStr=2025-08-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896581398, onlineDateStr=2026-08-05, pubDate=1765900800000, pubDateStr=2025-12-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896581398, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896581398, creator=13701087609, updateTime=1785896581398, updator=13701087609, issue=Issue{id=1291707045514858818, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='23', pageStart='3301', pageEnd='3450', issueExtLink='null', onlineDate='null', pubDate='1765900800000', pubDateStr='2025-12-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896558407, creator='13701087609', updateTime=1785896663780, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707487678390577, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707487682584882, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707045514858818, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3415, endPage=3420, ext={EN=ArticleExt(id=1291707144815006298, articleId=1291707141950296663, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on microbial linear plasmids from 1994 to 2023, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To systematically analyze the linear plasmid-related studies published from 1994 to 2023 by using bibliometric methods, and to sort out the research pattern, core forces and development context of this field.
Methods A total of 989 linear plasmid-related literatures indexed in the Web of Science Core Collection were selected as research objects. Bibliometric analysis was carried out from the dimensions of country, institution, journal, author and keyword by using CiteSpace (a literature analysis software) and GraphPad Prism (a graphing software).
Results Linear plasmids were taken as the core research object. The United States and Germany together contributed 53% of the relevant literature, with the USA National Institutes of Health (NIH) ranking first in the number of publications (50 papers). Journal of Bacteriology has published 80 papers on this topic, and German scholar Meinhardt Friedhelm (16 papers) is the core author in this field. Among them,Borrelia burgdorferi is the classic research microorganism, and the research hotspots include comparative genomics, replication and horizontal transfer mechanisms, and gene regulation. In addition, the dissemination of antibacterial drug resistance genes mediated by linear plasmids and the evolution of resistant plasmids have also attracted great attention.
Conclusion Over the past 30 years, research on linear plasmids has evolved from sequence analysis to functional mechanism exploration, and has continuously integrated new technologies. However, the current research still has limitations such as insufficient breadth and depth. In the future, international cooperation should be strengthened to conduct in-depth research on linear plasmids, which can provide theoretical support for the formulation of drug resistance prevention and control strategies and the development of new antibacterial drugs.
, authors=Bo SU, Bo ZHENG, authorsList=Bo SU, Bo ZHENG, authorCompany=null, correspAuthors=Bo ZHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707146060714587, articleId=1291707141950296663, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=1994~2023年微生物线性质粒研究进展, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 采用文献计量学方法系统解析1994~2023年发表的线性质粒相关研究，梳理该领域的研究格局、核心力量与发展脉络。
方法 以Web of Science核心数据库收录的989篇线性质粒相关文献为研究对象，运用CiteSpace文献分析与GraphPad Prism绘图软件，从国家、机构、期刊、作者及关键词等维度进行计量分析。
结果 线性质粒为核心研究对象，美国与德国合计贡献53%文献，美国国立卫生研究院发文量居首（50篇），“Journal of Bacteriology”发文80篇，德国学者Meinhardt Friedhelm（16篇）为核心作者。其中，经典研究微生物为伯氏疏螺旋体，热点方向为比较基因组学、复制及水平转移机制、基因调控等，线性质粒介导的抗菌药物耐药基因传播、耐药质粒演化也引发高度关注。
结论 30年间线性质粒研究从解析序列发展到功能机制探索，且不断融合新技术，但研究尚存在广度、深度不足等问题，未来可加强国际合作深入研究线性质粒，可为耐药防控策略制定和新型抗菌药物研发提供理论支撑。
, authors=苏博, 郑波, authorsList=苏博, 郑波, authorCompany=null, correspAuthors=郑波, authorNote=
苏博（1999-），男，硕士研究生，主要从事细菌耐药机制方面的研究
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苏博（1999-），男，硕士研究生，主要从事细菌耐药机制方面的研究
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