Article(id=1291707112061690459, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.21.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749484800000, receivedDateStr=2025-06-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896574273, onlineDateStr=2026-08-05, pubDate=1763308800000, pubDateStr=2025-11-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896574273, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896574273, creator=13701087609, updateTime=1785896574273, updator=13701087609, issue=Issue{id=1291706987964822180, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='21', pageStart='3001', pageEnd='3150', issueExtLink='null', onlineDate='null', pubDate='1763308800000', pubDateStr='2025-11-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896544684, creator='13701087609', updateTime=1785896721343, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707729324826977, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707729324826978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3043, endPage=3048, ext={EN=ArticleExt(id=1291707114049790556, articleId=1291707112061690459, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research on the neuroprotective effect of total flavonoids of Patrinia scabra on rats with ischemic stroke by regulating the RhoA/ROCK pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of total flavonoids from Patrinia on neuroprotection in rats with ischemic stroke (IS) by Rat sarcoma virus oncogene homolog (Ras) homolog gene family member (Rho) A/Rho-associated kinase (ROCK) signaling pathway.
Methods The IS rat model was established by the suture method, and was randomly divided into B group (IS), C group (total senna flavonoids low dose), D group (total senna flavonoids high dose), E group (positive drug), F group (high dose of total senna flavonoids+U-46619F) and A group (the sham operation), where group A and group B were given intragastric and intraperitoneal injections of normal saline; group C was given 100 mg·kg-1 total senna flavonoids by intragastric administration; group D was given 200 mg·kg-1 total senna flavonoids by intragastric administration; group E was given 1.0 mg·kg-1 nimodipine by intraperitoneal injection; group F was given intragastric administration of 200 mg·kg-1 total senna flavonoids and 30 μg·kg-1 U-46619 by intraperitoneal injection; each group was administered once a day for two consecutive weeks. After the intervention, the modified neurological severity (mNSS) score was used to evaluate the nerve injury; the triphenyltetrazolium chloride staining (TTC) was used to detect the ratio of cerebral infarction area; the brain tissue was separated, and hematoxylin-eosin was used for pathological changes; the expression of nerve growth factor (NGF) was detected by immunohistochemistry; the apoptosis changes of striatal dopaminergic neurons were detected by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling method (TUNEL); the relative expression levels of Bcl-2 related X protein (Bax), RhoA, ROCK and B-cell lymphoma factor 2 (Bcl-2) proteins were detected by immunoblotting.
Results The nerve injury scores for groups A, B, D, E, and F were (0.15±0), (11.24±1.26), (4.06±0.42), (3.52±0.38) and (7.18±0.73) points, respectively; the ratio of infarct area were (0±0)%, (27.86±2.81)%, (11.57±1.27)%, (12.07±1.24)% and (18.07±1.88)%; the relative expression levels of NGF were 34.11±3.51, 15.86±1.61, 32.07±3.28, 32.11±3.32 and 22.87±2.31; the apoptosis of dopaminergic neurons were (6.57±0.68)%, (27.81±2.82)%, (12.75±1.31)%, (12.52±1.27)% and (20.47±2.11)%; the aforementioned indicators of group B were compared with those of group A; those of groups C and D were compared with group B; and those of group F were compared with group D, all showing statistically significant differences (all P<0.05).
Conclusion The total flavonoids of Cynanchum paniculatum have neuroprotective effects on IS rats, and the mechanism may be related to the activation of the RhoA/ROCK signaling pathway.
, authors=Qun-cheng NIE
1, Xiao-tong JIA
1, Peng-fei LIU
2, authorsList=Qun-cheng NIE, Xiao-tong JIA, Peng-fei LIU, authorCompany=null, correspAuthors=Peng-fei LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707115731706463, articleId=1291707112061690459, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=败酱总黄酮调节RhoA/ROCK通路对缺血性脑卒中大鼠神经保护的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究败酱总黄酮调节大鼠肉瘤病毒癌基因同源物（Ras）同源基因家族成员（Rho）A/Rho相关激酶（ROCK）信号通路对缺血性脑卒中（IS）大鼠的神经保护作用的影响。
方法 通过线栓法建立IS大鼠模型，并随机分为B组（IS）、C组（败酱总黄酮低剂量）、D组（败酱总黄酮高剂量）、E组（阳性药组）、F组（败酱总黄酮高剂量+U-46619F），并以不插入缝合线的大鼠为A组（假手术），A、B组均以生理盐水灌胃及腹腔注射；C组以100 mg·kg-1败酱总黄酮灌胃；D组以200 mg·kg-1败酱总黄酮灌胃；E组以1.0 mg·kg-1的尼莫地平腹腔注射；F组以灌胃200 mg·kg-1败酱总黄酮，同时以30 μg·kg-1 U-46619腹腔注射；各组均每天1次，连续2周。干预结束后，用改良神经功能缺损（mNSS）评分评估神经损伤；用氯化三苯基四氮唑染色（TTC）法检测脑梗死面积比；分离脑组织，用苏木精-伊红法检测病理学变化；用免疫组化法检测神经生长因子（NGF）表达；用末端脱氧核苷酸转移酶介导的dUTP缺口末端标记法（TUNEL）检测纹状体多巴胺能神经元凋亡变化；用蛋白质印迹法检测Bcl-2相关X蛋白（Bax）、RhoA、ROCK、B细胞淋巴瘤因子2（Bcl-2）蛋白表达。
结果 A、B、D、E及F组神经损伤评分分别为（0.15±0）、（11.24±1.26）、（4.06±0.42）、（3.52±0.38）及（7.18±0.73）分；梗死面积比（0±0）%、（27.86±2.81）%、（11.57±1.27）%、（12.07±1.24）%及（18.07±1.88）%；NGF表达34.11±3.51、15.86±1.61、32.07±3.28、32.11±3.32及22.87±2.31；多巴胺能神经元凋亡（6.57±0.68）%、（27.81±2.82）%、（12.75±1.31）%、（12.52±1.27）%及（20.47±2.11）%；B组的上述指标与A组比较；C和D组的上述指标与B组比较；F组的上述指标与D组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 败酱总黄酮对IS大鼠具有神经保护作用，其机制可能与激活RhoA/ROCK信号通路有关。
, authors=聂群成
1, 贾晓彤
1, 刘鹏飞
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聂群成（1990-），男，讲师，主要从事中西医结合康复治疗方面的研究
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