Article(id=1291707066587050165, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.22.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747756800000, receivedDateStr=2025-05-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896563431, onlineDateStr=2026-08-05, pubDate=1764259200000, pubDateStr=2025-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896563431, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896563431, creator=13701087609, updateTime=1785896563431, updator=13701087609, issue=Issue{id=1291707004800750583, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='22', pageStart='3151', pageEnd='3300', issueExtLink='null', onlineDate='null', pubDate='1764259200000', pubDateStr='2025-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896548700, creator='13701087609', updateTime=1785896693213, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707610999316815, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707610999316816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3178, endPage=3184, ext={EN=ArticleExt(id=1291707068143136950, articleId=1291707066587050165, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical study of dulaglutide combined with letrozole tablets in the treatment of infertility patients with obese polycystic ovary syndrome, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy of dulaglutide injection combined with letrozole tablets in the treatment of obese polycystic ovary syndrome (PCOS) infertility patients.
Methods Obese infertility patients with PCOS were divided into control group and treatment group according to medication regimen. The control group was given letrozole tablets 5 mg orally, once a day for 3 months on the basis of conventional treatment; the treatment group was given dulaglutide injection 1.5 mg, subcutaneous injection once a week, and letrozole tablets were treated with the same method as the control group for 3 months. The clinical efficacy, glucose metabolism characteristics, visceral fat, body composition and the occurrence of adverse drug reactions were compared between the two groups.
Results 42 patients were included in the treatment group and 38 in the control group. After treatment, the total effective rate of treatment group and control group was 90.48% (38 cases /42 cases) and 73.68% (28 cases /38 cases), the difference was statistically significant (P<0.05). After treatment, the fasting plasma glucose (FPG) of the treatment group and the control group were (4.37±0.85) and (4.84±0.81) mmol·L-1, respectively; glycosylated hemoglobin (HbA1c) were (4.84±0.82)% and (5.25±0.88)%, respectively; homeostasis model assessment for insulin resistance (HOMA-IR) were 2.45±0.41 and 2.73±0.48, respectively; visceral fat mass were (687.19±97.29) and (739.37±105.24) g, respectively; visceral fat volume were (751.21±106.34) and (821.82±112.64) cm3, respectively; visceral fat area were (143.29±27.88) and (156.39±25.26) cm2, respectively; body mass index (BMI) were (32.04±3.65) and (34.33±3.56) kg·m-2, respectively; waist-hip ratio (WHR) were 0.96±0.22 and 1.10±0.25, respectively; body fat percentage were (31.43±4.87)% and (34.37±4.54)%, respectively. The differences of the above indexes between the two groups were statistically significant (P<0.05, P<0.01). The main adverse drug reactions in the treatment group were nausea, vomiting, and loss of appetite, while no obvious adverse reactions occurred in the control group. There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05).
Conclusion Dulaglutide injection combined with letrozole tablets has significant clinical efficacy in the treatment of obese PCOS infertility patients, which can regulate the level of glucose and lipid metabolism, visceral fat content and body composition, reduce insulin resistance, and has certain safety.
, authors=Jing-jing LIU, Li-ping WU, Ning-ning DU, authorsList=Jing-jing LIU, Li-ping WU, Ning-ning DU, authorCompany=null, correspAuthors=Jing-jing LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707068667424951, articleId=1291707066587050165, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=度拉糖肽联合来曲唑片治疗肥胖型多囊卵巢综合征不孕症患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察度拉糖肽注射液联合来曲唑片治疗肥胖型多囊卵巢综合征（PCOS）不孕症患者的临床治疗效果。
方法 将肥胖型PCOS不孕症患者按用药方案分为对照组和试验组。对照组在常规用药基础上给予来曲唑片5 mg，口服，qd，治疗3个月；试验组给予度拉糖肽注射液1.5 mg，皮下注射，每周1次，来曲唑片用药方法同对照组，治疗3个月。比较2组患者的临床疗效、糖代谢特征、内脏脂肪、身体成分以及药物不良反应的发生情况。
结果 试验组纳入42例，对照组纳入38例。治疗后，试验组和对照组患者总有效率为90.48%（38例/42例）和73.68%（28例/38例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组患者的空腹血糖（FPG）分别为（4.37±0.85）和（4.84±0.81）mmol·L-1；糖化血红蛋白（HbA1c）分别为（4.84±0.82）%和（5.25±0.88）%；胰岛素抵抗指数（HOMA-IR）分别为2.45±0.41和2.73±0.48；内脏脂肪质量分别为（687.19±97.29）和（739.37±105.24）g；内脏脂肪体积分别为（751.21±106.34）和（821.82±112.64）cm3；内脏脂肪面积分别为（143.29±27.88）和（156.39±25.26）cm2；身体质量指数（BMI）分别为（32.04±3.65）和（34.33±3.56）kg·m-2；腰臀比（WHR）分别为0.96±0.22和1.10±0.25；体脂率分别为（31.43±4.87）%和（34.37±4.54）%，上述指标2组间比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）。试验组的药物不良反应主要有恶心、呕吐、食欲不振，而对照组则未出现明显的不良反应。2组的不良反应总发生率上在统计学上差异无统计学意义（P>0.05）。
结论 度拉糖肽注射液联合来曲唑片治疗肥胖型PCOS不孕症患者的临床疗效显著，可调节糖脂代谢水平、内脏脂肪含量及身体成分，降低胰岛素抵抗，且具有一定安全性。
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刘晶晶（1983-），女，副主任医师，主要从事生殖医学方面工作和研究
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