Article(id=1291707038594265150, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.22.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747238400000, receivedDateStr=2025-05-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896556757, onlineDateStr=2026-08-05, pubDate=1764259200000, pubDateStr=2025-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896556757, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896556757, creator=13701087609, updateTime=1785896556757, updator=13701087609, issue=Issue{id=1291707004800750583, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='22', pageStart='3151', pageEnd='3300', issueExtLink='null', onlineDate='null', pubDate='1764259200000', pubDateStr='2025-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896548700, creator='13701087609', updateTime=1785896693213, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707610999316815, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707610999316816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3164, endPage=3170, ext={EN=ArticleExt(id=1291707038871089215, articleId=1291707038594265150, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial on thoracolumbar interfascia plane block with ropivacaine combined with betamethasone in elderly patients undergoing lumbar spine surgery, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the clinical efficacy and safety of thoracolumbar fascia plane block with ropivacaine hydrochloride injection combined with compound betamethasone injection in elderly patients undergoing lumbar spine surgery during the perioperative period.
Methods The elderly patients admitted to our hospital who underwent posterolateral approach lumbar fusion (PLIF) under general anesthesia due to lumbar degenerative diseases were divided into control group and treatment group according to different anesthesia methods. Both groups of patients received thoracolumbar fascia plane (TLIP) block. Control group was injected with a single dose of 20 mL of 0.375% ropivacaine hydrochloride injection, while treatment group was injected with a single dose of a mixture of 20 mL of 0.375% ropivacaine hydrochloride injection and 5 mg of compound betamethasone injection for TLIP block. The remaining operations were same. The hemodynamic indicators, rehabilitation process indicators, opioid dosage and remedial analgesia conditions, visual analogue scale (VAS) scores at rest and turning over at different time points, stress and immune indicators of the two groups of patients were compared, and safety evaluations were conducted.
Results A total of 115 cases were screened in this study, with 102 cases enrolled. Among them, 50 cases were enrolled in control group and 52 cases in treatment group. The heart rate (HR) of the control group and the treatment group at T4 were (82.13±10.68) and (74.81±10.19) times·min-1, respectively; and the mean arterial pressure (MAP) were (92.33±9.87) and (88.27±8.92) mmHg, respectively; the recovery time were (36.41±6.97) and (31.87±6.53) min, respectively; and the resting VAS scores at 48 hours after the operation were (2.71±0.88) and (2.56±0.82) points, respectively; the VAS scores at turning over 48 hours after the operation were (3.42±0.97) and (2.88±0.84) points, respectively; the first PCIA time were (20.04±5.67) and (16.79±4.32) hours, respectively; the effective compression times of PCIA were (14.19±4.36) and (11.64±3.52) times, respectively; and the β-Endorphin (β -endorphin) 24 hours after the operation were (160.31±19.68) and (146.83±18.49) pg·mL-1, respectively; CC Chemokine ligand 2 (CCL2) were (109.39±19.78) and (97.86±17.88) pg·mL-1, respectively; angiotensin Ⅱ (Ang Ⅱ) were (79.14±12.53) and (70.65±11.71) pg·mL-1, respectively. The above indicators of treatment group were compared with those of control group, and the differences were all statistically significant (all P<0.05). The incidence rates of adverse reactions to anesthetic drugs during the perioperative period in the two groups of patients were 9.62%(5 cases/52 cases) and 16.00%(8 cases/50 cases), respectively, and there was no statistically significant difference (P>0.05).
Conclusion The TLIP block with ropivacaine combined with betamethasone can enhance the analgesic effect during the perioperative period of patients undergoing PLIF, reduce the dosage of opioid drugs, alleviate early pain symptoms and the level of postoperative stress responses, and has a relatively high level of safety.
, authors=Hui-jie MA
1, 2, Min LI
1, Gui-zhi WANG
1, Yin-gui SUN
2, authorsList=Hui-jie MA, Min LI, Gui-zhi WANG, Yin-gui SUN, authorCompany=null, correspAuthors=Yin-gui SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707039265353792, articleId=1291707038594265150, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=罗哌卡因联合倍他米松胸腰筋膜平面阻滞对老年腰椎手术患者围术期的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究盐酸罗哌卡因注射液联合复方倍他米松注射液胸腰筋膜平面阻滞对老年腰椎手术患者围术期的临床疗效和安全性。
方法 将本院收治的因腰椎退行性疾病在全麻下进行后外侧入路腰椎融合术（PLIF）的老年患者根据麻醉方式的不同分为对照组和试验组。2组患者均接受胸腰筋膜平面（TLIP）阻滞，对照组单次注射0.375%盐酸罗哌卡因注射液20 mL；试验组单次注射0.375%盐酸罗哌卡因注射液20 mL复合复方倍他米松注射液5 mg的混合液进行TLIP阻滞，其余操作相同。比较2组患者的血流动力学指标、康复进程指标、阿片药物用量及补救镇痛情况、不同时间点静息和翻身时视觉模拟疼痛（VAS）评分、应激和免疫指标，并进行安全性评价。
结果 本研究共筛选115例，入组102例，对照组入组50例，试验组入组52例。对照组和试验组T4时的心率（HR）分别为（82.13±10.68）和（74.81±10.19）times·min-1，平均动脉压（MAP）分别为（92.33±9.87）和（88.27±8.92）mmHg，苏醒时间分别为（36.41±6.97）和（31.87±6.53）min，术后48 h静息时VAS评分分别为（2.71±0.88）和（2.56±0.82）分，术后48 h翻身时VAS评分分别为（3.42±0.97）和（2.88±0.84）分，术后首次患者自控静脉镇痛（PCIA）时间分别为（20.04±5.67）和（16.79±4.32）h，PCIA有效按压次数分别为（14.19±4.36）和（11.64±3.52）次，术后24 h的β-内啡肽（β-Endorphin，β-EP）分别为（160.31±19.68）和（146.83±18.49）pg·mL-1，CC趋化因子配体2（CCL2）分别为（109.39±19.78）和（97.86±17.88）pg·mL-1，血管紧张素Ⅱ（AngⅡ）分别为（79.14±12.53）和（70.65±11.71）pg·mL-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。2组患者围术期麻醉药物不良反应发生率分别为9.62%（5例/52例）和16.00%（8例/50例），在统计学上差异无统计学意义（P>0.05）。
结论 罗哌卡因复合倍他米松TLIP阻滞能够增强PLIF患者围术期的镇痛效果，减少阿片类药物用量，降低早期疼痛症状和术后应激反应水平，且安全性较高。
, authors=马慧洁
1, 2, 李敏
1, 王桂芝
1, 孙银贵
2, authorsList=马慧洁, 李敏, 王桂芝, 孙银贵, authorCompany=null, correspAuthors=孙银贵, authorNote=
马慧洁（1999-），女，在读硕士研究生，主要从事围手术期麻醉调控方面的临床工作和研究
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1.School of Anesthesiology, Shandong Second Medical University, Weifang 261053, Shandong Province, China
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